Kivonat:
Direct extension and hematogenous metastasis of primary non-CNS
malignant tumors to the CNS are rare complications in children.
The authors analyzed the incidence and outcome of these
complications in Hungary. During a 14-year period between 1989
and 2002, 406 patients younger than 18 years were studied at
Semmelweis University, Second Department of Pediatrics, in
Budapest. Among the 406 patients with non-CNS solid tumors, nine
hematogenous metastases and five direct tumor extensions to the
CNS occurred. Primary tumors included rhabdomyosarcoma,
neuroblastoma, tumors of the Ewing sarcoma family, non-Hodgkin
lymphoma, and malignant chordoma. Mean interval between the
initial diagnosis and the diagnosis of CNS involvement was 11.4
months. Despite intensive treatment, the mean survival after
detection of CNS involvement was 10.4 months. The frequency of
CNS involvement in non-CNS tumors is low, with a very poor
survival.