tallózása szerző szerint "Tóvári, József"

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  • Mechanism of tumour vascularisation in experimental lung metastases 
    Szabó, Vanessza; Bugyik, Edina; Dezső, Katalin; Ecker N; Nagy, Péter; Tímár, József; Tóvári, József; Laszlo, Viktoria; Bridgeman VL; Wan E; Frentzas S; Vermeulen PB; Reynolds AR; Döme, Balázs; Paku, Sándor (2015)
    The appearance of lung metastases is associated with poor outcome and the management of patients with secondary pulmonary tumours remains a clinical challenge. We examined the vascularisation process of lung metastasis in ...
  • Next Generation Lipophilic Bisphosphonate Shows Antitumor Effect in Colorectal Cancer In Vitro and In Vivo 
    Baranyi, Marcell; Rittler, Dominika; Molnár, Eszter; Shirasawa, Senji; Jalsovszky, István; Varga, Imre Károly; Hegedűs, Luca; Németh, Afrodíté; Dank, Magdolna; Aigner, Clemens; Tóvári, József; Tímár, József; Hegedűs, Balázs; Garay, Tamás (2020)
  • Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells 
    Molnár, Eszter; Rittler D; Baranyi, Marcell; Grusch M; Berger W; Döme, Balázs; Tóvári, József; Aigner C; Tímár, József; Garay, Tamás; Hegedűs, Balázs (2018)
    BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, ...
  • Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells. 
    Garay, Tamás; Kenessey, István; Molnár, Eszter; Juhasz E; Réti, Andrea; Laszlo V; Rozsas A; Dobos J; Döme, Balázs; Berger W; Klepetko W; Tóvári, József; Tímár, József; Hegedűs, Balázs (2015)
    While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we ...
  • Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase 
    Lövey, József; Nie D; Tóvári, József; Kenessey, István; Tímár, József; Kandouz M; Honn KV (2013)
  • Revisiting CB1 Receptor as Drug Target in Human Melanoma 
    Kenessey, István; Bánky, Balázs; Márk, Ágnes; Varga N,; Tóvári, József; Ladányi, Andrea; Rásó, Erzsébet; Tímár, József (2012)
    Previous studies have indicated the antitumoral effect of human melanocytes, human melanoma cell lines expressing CB1 receptor (CB1), and of the peritumoral administration of endocannabinoids. In the present study, we ...
  • Sex-dependent liver colonization of human melanoma in SCID mice-role of host defense mechanisms 
    Dobos, Judit; Mohos, Anita; Tóvári, József; Rásó, Erzsébet; Lőrincz, Tamás; Zádori, Gergely; Tímár, József; Ladányi, Andrea (2013)
    The possibility that endocrine factors may influence the clinical course of malignant melanoma is suggested by the superior survival data of women. In preclinical models we observed a higher rate of colony formation by ...
  • Significance of the Tks4 scaffold protein in bone tissue homeostasis 
    Vas, Virág; Kovács, Tamás; Körmendi, Szandra Katalin; Bródy, Andrea; Kudlik, Gyöngyi; Szeder, Bálint; Mező, Diána; Kállai, Dóra; Koprivanacz, Kitti; Merő, Balázs László; Dülk, Metta; Tóvári, József; Vajdovich, Péter; Şenel, Ş Neslihan; Özcan, Ilknur; Helyes, Zsuzsanna; Dobó-Nagy, Csaba; Buday, László (2019)
    The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic alterations in key osteogenic factors and dysfunction of bone marrow ...
  • Szemelvények a Semmelweis Egyetem, az Országos Onkológiai Intézet és az Országos Korányi Tbc és Pulmonológiai Intézet együttműködésén alapuló tüdőrák-kutatási programból 
    Hegedűs, Balázs; Moldvay, Judit; Berta, Judit; Lohinai, Zoltán; Rózsás, Anita; Cserepes, Tamás Mihály; Fábián, Katalin; Ostoros G; Tóvári, József; Rényi-Vámos, Ferenc István; Tímár, József; Döme, Balázs (2015)
    Lung cancer places a significant socio-economic burden on the Hungarian population. This overview summarizes the findings of collaborative translational lung cancer research efforts of three Hungarian flagship academic ...
  • The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner 
    Keller-Pinter, Anikó; Ughy, Bettina; Domoki, Mónika; Pettkó-Szandtner, Aladár; Letoha T; Tóvári, József; Tímár, József; Szilák, László (2017)
    The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound ...
  • The Prognostic Role of Claudins in Head and Neck Squamous Cell Carcinomas. 
    Nelhubel GA; Karoly B; Szabó, Balázs; Lotz, Gábor; Kiss, András; Tóvári, József; Kenessey, István (2014)
    The expression of tight junction proteins is frequently altered in epithelial cancers. The loss of cell-cell adhesion associates with enhanced metastatic potential, which underlies the role of altered expression pattern ...
  • Visualization of Calcium Dynamics in Kidney Proximal Tubules 
    Szebényi, Kornélia; Füredi, András; Kolacsek, Orsolya; Csohány, Rózsa; Prókai, Ágnes; Kis-Petik, Katalin; Szabó, Attila; Bosze Z; Bender B; Tóvári, József; Enyedi, Ágnes; Orbán, Tamás I.; Apáti, Ágota; Sarkadi, Balázs (2015)
    Intrarenal changes in cytoplasmic calcium levels have a key role in determining pathologic and pharmacologic responses in major kidney diseases. However, cell-specific delivery of calcium-sensitive probes in vivo remains ...