tallózása szerző szerint "Bánhegyi, Gábor"

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A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis

Kapuy, Orsolya; Vinod PK; Mandl, József; Bánhegyi, Gábor (2013)

Decision-making between life and death is one of the most important tasks of cells to maintain their genetic integrity. While the surviving mechanism is driven by Beclin1-dependent autophagy, the suicide processes are ...
A comprehensive systems biological study of autophagy-apoptosis crosstalk during endoplasmic reticulum stress

Holczer M; Márton M; Kurucz, Anita; Bánhegyi, Gábor; Kapuy, Orsolya (2015)

One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress. Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, ...
Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades.

Nagy, Szilvia Krisztina; Darula, Zsuzsanna; Kállai, Brigitta Margit; Bogre L; Bánhegyi, Gábor; Medzihradszky F., Katalin; Horváth V., Gábor; Mészáros, Tamás (2015)

Mitogen activated protein kinases (MAPKs) are part of conserved signal transduction modules in eukaryotes that are typically organised into three-tiered kinase cascades. The activation of MAPKs in these pathways is fully ...
A double negative feedback loop between MTORC1 and AMPK kinases guarantees precise autophagy induction upon cellular stress

Holczer, Marianna; Hajdú, B.; Lőrincz, T; Szarka, A; Bánhegyi, Gábor; Kapuy, Orsolya (2019)

Cellular homeostasis is controlled by an evolutionary conserved cellular digestive process called autophagy. This mechanism is tightly regulated by the two sensor elements called mTORC1 and AMPK. mTORC1 is one of the master ...
A Systems Biological Perspective of Cellular Stress-Directed Programmed Cell Death

Kapuy, Orsolya; Lizák, Beáta; Stiller, Ibolya; Bánhegyi, Gábor (2014)
A systems biological view of life-and-death decision with respect to endoplasmic reticulum stress—The role of PERK pathway

Márton, Margita; Kurucz, Anita; Lizák, Beáta; Margittai, Éva; Bánhegyi, Gábor; Kapuy, Orsolya (2017)

Accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to the activation of three branches (Protein kinase (RNA)-like endoplasmic reticulum kinase [PERK], Inositol requiring protein 1 [IRE-1] ...
BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury

Nagy G,; Szarka, András; Lotz, Gábor; Dóczi, Judit; Wunderlich, Lívius; Kiss, András; Jemnitz, Katalin; Veres, Zsuzsa; Bánhegyi, Gábor; Schaff, Zsuzsa; Sümegi, Balázs; Mandl, József (2010)

It has been recently shown that acute acetaminophen toxicity results in endoplasmic reticulum redox stress and an increase in cells with apoptotic phenotype in liver. Since activation of effector caspases was absent, the ...
Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

Lizák, Beáta; Birk, Julia; Zana, Melinda; Kosztyi, Gergely; Kratschmar, Denise V; Odermatt, Alex; Zimmermann, Richard; Geiszt, Miklós; Appenzeller-Herzog, Christian; Bánhegyi, Gábor (2020)

The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair. Although ...
Composition of the redox environment of the endoplasmic reticulum and sources of hydrogen peroxide

Margittai, Éva; Enyedi, Balázs; Csala, Miklós; Geiszt, Miklós; Bánhegyi, Gábor (2015)
Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients

Németh, Csilla Emese; Nemoda, Zsófia; Lőw, Péter; Szabó Pál; Horváth Erzsébet Z; Willaert Andy; Boel Annekatrien; Callewaert Bert L.; Coucke Paul J.; Colombi Marina; Bánhegyi, Gábor; Margittai, Éva (2019)
Depletion of luminal pyridine nucleotides in the endoplasmic reticulum activates autophagy with the involvement of mTOR pathway

Kapuy, Orsolya; Bánhegyi, Gábor (2013)

It has been recently shown that redox imbalance of luminal pyridine nucleotides in the endoplasmic reticulum (ER) together with oxidative stress results in the activation of autophagy. In the present study we demonstrated ...
Effect of pulsed electromagnetic fields on endoplasmic reticulum stress

Keczan E; Kéri, György; Bánhegyi, Gábor; Stiller, Ibolya (2016)

The maintenance of protein homeostasis in the endoplasmic reticulum (ER) is crucial in cell life. Disruption of proteostasis results in ER stress that activates the unfolded protein response (UPR); a signalling network ...
Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

Holczer, Marianna; Besze B; Zámbó, Veronika; Csala, Miklós; Bánhegyi, Gábor; Kapuy, Orsolya (2018)
Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation

Holczer, Marianna; Hajdú, B; Lőrincz, T; Szarka, Aandrás; Bánhegyi, Gábor; Kapuy, Orsolya (2020)

Autophagy is an intracellular digestive process, which has a crucial role in maintaining cellular homeostasis by self-eating the unnecessary and/or damaged components of the cell at various stress events. ULK1, one of the ...
Fructose, glucocorticoids and adipose tissue: Implications for the metabolic syndrome

Legeza, Balázs; Marcolongo P; Gamberucci A; Varga V; Bánhegyi, Gábor; Benedetti A; Odermatt A (2017)

The modern Western society lifestyle is characterized by a hyperenergetic, high sugar containing food intake. Sugar intake increased dramatically during the last few decades, due to the excessive consumption of high-sugar ...
GADD34 keeps the mTOR pathway inactivated in endoplasmic reticulum stress related autophagy

Holczer, Marianna; Bánhegyi, Gábor; Kapuy, Orsolya (2016)

The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of rapamycin serine/threonine kinase) pathway and unfolded protein response ...
Glucose Transport and Transporters in the Endomembranes

Lizák, Beáta; Szarka, András; Kim, Yejin; Choi, Kyu-Sung; Németh, Csilla Emese; Marcolongo, Paola; Benedetti, Angelo; Bánhegyi, Gábor; Margittai, Éva (2019)

Glucose is a basic nutrient in most of the creatures; its transport through biological membranes is an absolute requirement of life. This role is fulfilled by glucose transporters, mediating the transport of glucose by ...
Glucose transporter type 10 - lacking in arterial tortuosity syndrome - facilitates dehydroascorbic acid transport

Németh, Csilla Emese; Marcolongo P; Gamberucci A; Fulceri R; Benedetti A; Gróf, Pál; Nagy, Szilvia Krisztina; Mészáros, Tamás; Bánhegyi, Gábor; Margittai, Éva (2016)

Loss-of-function mutations in the gene encoding GLUT10 are responsible for arterial tortuosity syndrome (ATS), a rare connective tissue disorder. In the present study GLUT10 mediated dehydroascorbic acid (DAA) transport ...
Lipotoxicity in the liver

Zámbó, Veronika; Simon-Szabó, Laura; Szelényi, Péter; Kereszturi, Éva; Bánhegyi, Gábor; Csala, Miklós (2013)

Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21st century. With the increasing prevalence of obesity, non-alcoholic fatty liver ...
Minireview: Endoplasmic reticulum stress: Control in protein, lipid, and signal homeostasis

Mandl, József; Mészáros, Tamás; Bánhegyi, Gábor; Csala, Miklós (2013)

Endoplasmic reticulum (ER) stress is a regulatory mechanism that allows cells to adapt to a series of metabolic, redox, and other environmental changes. The role of ER stress was first identified in the maintenance of ...

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