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Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts

Barone I; Vircillo V; Giordano C; Gelsomino L; Győrffy, Balázs; Tarallo R; Rinaldi A; Bruno G; Caruso A; Romeo F; Bonofiglio D; Andò S; Catalano S (2018)

Cancer-associated Fibroblasts (CAFs), the principal components of tumor microenvironment, play multiple role in breast cancer progression. We have previously shown an oncosuppressive role of the nuclear Farnesoid X Receptor ...
Expression and function of phosphodiesterase type 5 in human breast cancer cell lines and tissues: Implications for targeted therapy

Catalano S; Campana A; Giordano C; Győrffy, Balázs; Tarallo R; Rinaldi A; Bruno G; Ferraro A; Romeo F; Lanzino M; Naro F; Bonofiglio D; Andò S; Barone I (2016)

Purpose: By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) 5 is a critical regulator of its concentration and effects in different (patho)physiologic processes, including cancers. As PDE5 is a known druggable target, ...
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity

Giordano C; Chemi F; Panza S; Barone I; Bonofiglio D; Lanzino M; Cordella A; Campana A; Hashim A; Rizza P; Leggio A; Győrffy, Balázs; Simões BM; Clarke RB; Weisz A; Catalano S; Andò S (2016)

Breast cancer stem cells (BCSCs) play crucial roles in tumor initiation, metastasis and therapeutic resistance. A strict dependency between BCSCs and stromal cell components of tumor microenvironment exists. Thus, novel ...

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tallózása szerző szerint "Bonofiglio D"

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