tallózása szerző szerint "Enyedi, Péter"

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Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel.

Lengyel, Miklós; Erdélyi, Ferenc; Pergel, Enikő; Bálint-Polonka, Ágnes; Dobolyi, Alice; Bozsaki, Péter; Dux, Mária; Király, Kornél; Hegedűs, Tamás; Czirják, Gábor; Mátyus, Péter; Enyedi, Péter (2019)

Cloxyquin has been reported as a specific activator of TRESK (K2P18.1, TWIK-related spinal cord K+ channel) background potassium channel. In this study, we have synthetized chemically modified analogues of cloxyquin and ...
Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red

Braun, Gabriella; Lengyel, Miklós; Enyedi, Péter; Czirják, Gábor (2015)

BACKGROUND AND PURPOSE: Pharmacological separation of the background potassium currents of closely related K2P channels is a challenging problem. We previously demonstrated that ruthenium red (RR) inhibits TASK-3 (K2 P ...
Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits

Czirják, Gábor; Enyedi, Péter (2002)

The potassium channels in the two-pore domain family are widely expressed and regulate the excitability of neurons and other excitable cells. These channels have been shown to function as dimers, but heteromerization between ...
Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

Enyedi, Péter; Czirják, Gábor (2010)

Enyedi P, Czirjak G. Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels. Physiol Rev 90: 559-605, 2010; doi:10.1152/physrev.00029.2009.-Two-pore domain K+ (K-2P) channels give rise to leak (also ...
Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation

Czirják, Gábor; Vuity, D; Enyedi, Péter (2008)

The two-pore domain K+ channel, TRESK (TWIK-related spinal cord K+ channel) is reversibly activated by the calcium/calmodulin-dependent protein phosphatase, calcineurin. In the present study, we report that 14-3-3 proteins ...
Properties, regulation, pharmacology, and functions of the K2P channel, TRESK

Enyedi, Péter; Czirják, Gábor (2015)

TWIK-related spinal cord K+ channel (TRESK) is the gene product of KCNK18, the last discovered leak potassium K2P channel gene. Under resting conditions, TRESK is constitutively phosphorylated at two regulatory regions. ...
Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K(+)channel, TRESK

Czirják, Gábor; Enyedi, Péter (2006)

The two-pore domain K+ channel, TRESK (TWIK-related spinal cord K+ channel) is activated in response to the calcium signal by the calcium/calmodulin-dependent protein phosphatase, calcineurin. In the present study we report ...
Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH

Papp, Rita; Nagaraj, Chandran; Zabini, Diana; Nagy, Bence M; Lengyel, Miklós; Maurer, Davor Skofic; Sharma, Neha; Egemnazarov, Bakytbek; Kovacs, Gabor; Kwapiszewska, Grazyna; Marsh, Leigh M; Hrzenjak, Andelko; Höfler, Gerald; Didiasova, Miroslava; Wygrecka, Malgorzata; Sievers, Laura; Szucs, Peter; Enyedi, Péter; Ghanim, Bahil; Klepetko, Walter; Olschewski, Horst; Olschewski, Andrea Judit (2019)

Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial hypertension (IPAH) showed marked upregulation of the Cl- channel TMEM16A gene.We hypothesised that TMEM16A overexpression might ...
TASK-1 (KCNK3) channels in the lung: From cell biology to clinical implications

Olschewski A; Veale EL; Nagy BM; Nagaraj C; Kwapiszewska G; Antigny F; Lambert M; Humbert M; Czirják, Gábor; Enyedi, Péter; Mathie A (2017)

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. This gene subfamily is constitutively active at physiological resting membrane potentials ...
The LQLP Calcineurin-docking Site Is a Major Determinant of the Calcium-dependent Activation of Human TRESK Background K+ Channel

Czirják, Gábor; Enyedi, Péter (2014)

Calcium-dependent activation of human TRESK (TWIK-related spinal cord K+ channel, K2P18.1) depends on direct targeting of calcineurin to the PQIIIS motif. In the present study we demonstrate that TRESK also contains another ...
The Two-pore Domain K+ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin

Czirják, Gábor; Tóth, Zsuzsanna; Enyedi, Péter (2004)
TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes

Braun, Gabriella; Nemcsics, B; Enyedi, Péter; Czirják, Gábor (2011)

TRESK (TWIK-related spinal cord K(+) channel, KCNK18) is a major background K(+) channel of sensory neurons. Dominant-negative mutation of TRESK is linked to familial migraine. This important two-pore domain K(+) channel ...
TRESK (K2P18.1) Background Potassium Channel is Activated by Novel-Type Protein Kinase C via Dephosphorylation

Pergel, Enikő; Lengyel, Miklós; Enyedi, Péter; Czirják, Gábor (2019)

TRESK (K2P18.1) background K+ channel is a major determinant of the excitability of primary sensory neurons. It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate ...

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tallózása szerző szerint "Enyedi, Péter"

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