tallózása szerző szerint "Kökény, Gábor"

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Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer

Gasparics, Ákos; Kökény, Gábor; Fintha, Attila; Bencs R; Mózes, Miklós; Ágoston EI; Buday, Anna; Ivics, Zoltán; Hamar, Péter; Győrffy, Balázs; Rosivall, László; Sebe, Attila (2018)
Characterization and Role of SCAI during Renal Fibrosis and Epithelial-Mesenchymal Transition.

Fintha, Attila; Gasparics, Ákos; Fang, Lilla; Erdei, Zsuzsa; Hamar, Péter; Mózes, Miklós; Kökény, Gábor; Rosivall, László; Sebe, Attila (2013)

During progressive tubulointerstitial fibrosis, renal tubular epithelial cells transform into alpha-smooth muscle actin (SMA)- expressing myofibroblasts via epithelial-mesenchymal transition (EMT). SMA expression is ...
Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ss expression in type-1 diabetic rats

Czirok, Szabina Julia; Fang, Lilla; Radovits, Tamás; Szabo G; Szénási, Gábor; Rosivall, László; Merkely, Béla Péter; Kökény, Gábor (2017)

Decreased soluble guanylate cyclase activity and cGMP levels in diabetic kidneys were shown to influence the progression of nephropathy. The regulatory effects of soluble guanylate cyclase activators on renal signaling ...
Cinaciguat prevents the development of pathologic hypertrophy in a rat model of left ventricular pressure overload

Németh, Balázs Tamás; Mátyás, Csaba; Oláh, Attila; Lux, Árpád; Hidi, László; Ruppert, Mihály; Kellermayer, Dalma; Kökény, Gábor; Szabó, Gábor Balázs; Merkely, Béla Péter; Radovits, Tamás (2016)

Pathologic myocardial hypertrophy develops when the heart is chronically pressure-overloaded. Elevated intracellular cGMP-levels have been reported to prevent the development of pathologic myocardial hypertrophy, therefore ...
Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain

Szalay, Csaba Imre; Erdélyi, Katalin; Kökény, Gábor; Lajtar E; Godo M; Revesz C; Kaucsár, Tamás; Kiss, Norbert; Sárközy, Márta; Csont, Tamás Bálint; Krenács, Tibor; Szénási, Gábor; Pacher, Pál; Hamar, Péter (2015)

Chronic renal fibrosis is the final common pathway of end stage renal disease caused by glomerular or tubular pathologies. Genetic background has a strong influence on the progression of chronic renal fibrosis. We recently ...
Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation

Benke, Kálmán; Mátyás, Csaba; Sayour AA; Oláh, Attila; Németh, Balázs Tamás; Ruppert, Mihály; Szabo G; Kökény, Gábor; Horvath, Eszter Mária; Hartyánszky, István; Szabolcs, Zoltán; Merkely, Béla Péter; Radovits, Tamás (2017)

While heart transplantation (HTX) is the definitive therapy of heart failure, donor shortage is emerging. Pharmacological activation of soluble guanylate cyclase (sGC) and increased cGMP-signalling have been reported to ...
Prevention of the development of heart failure with preserved ejection fraction by the phosphodiesterase-5A inhibitor vardenafil in rats with type 2 diabetes

Mátyás, Csaba; Németh, Balázs Tamás; Oláh, Attila; Török, Marianna; Ruppert, Mihály; Kellermayer, Dalma; Barta BA; Szabó, Gábor Balázs; Kökény, Gábor; Horvath, Eszter Mária; Bódi, Beáta; Papp, Zoltán; Merkely, Béla Péter; Radovits, Tamás (2017)

AIMS: Heart failure with preserved ejection fraction (HFpEF) has a great epidemiological burden. The pathophysiological role of cyclic guanosine monophosphate (cGMP) signalling has been intensively investigated in HFpEF. ...
Simple, readily available clinical indices predict early and late mortality among patients with ANCA-associated vasculitis

Haris, Ágnes; Polner K; Aranyi J; Braunitzer H; Kaszas I; Rosivall, László; Kökény, Gábor; Mucsi I (2017)

BACKGROUND: The early identification of patients with ANCA-associated vasculitis (AAV) who are at increased risk for inferior clinical outcome at the time of diagnosis might help to optimize the immunosuppressive therapy. ...
Sustained hyperosmolarity increses TGF-beta1 and Egr-1 expression in the rat renal medulla.

Mózes, Miklós; Szoleczky, Petra; Rosivall, László; Kökény, Gábor (2017)

BACKGROUND: Although TGF-ss and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar ...
The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

Mátyás, Csaba; Németh, Balázs Tamás; Oláh, Attila; Hidi, László; Birtalan, Ede; Kellermayer, Dalma; Ruppert, Mihály; Korkmaz-Icoz S; Kökény, Gábor; Horvath, Eszter Mária; Szabó, Gábor Balázs; Merkely, Béla Péter; Radovits, Tamás (2015)

BACKGROUND: Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling. ...

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