tallózása szerző szerint "Korcsmáros, Tamás"

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Adaptation and learning of molecular networks as a description of cancer development at the systems-level: potential use in anti-cancer therapies

Gyurkó, Márton Dávid; Veres, Dániel; Módos, Dezső; Földvári-Nagy Lászlóné Lenti, Katalin; Korcsmáros, Tamás; Csermely, Péter (2013)

There is a widening recognition that cancer cells are products of complex developmental processes. Carcinogenesis and metastasis formation are increasingly described as systems-level, network phenomena. Here we propose ...
Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy

Türei, Dénes; Földvári-Nagy, László; Fazekas D,; Módos, Dezső; Kubisch J,; Földvári-Nagy Lászlóné Lenti, Katalin; Csermely, Péter; Korcsmáros, Tamás (2015)
Cancer-related networks: A help to understand, predict and change malignant transformation

Csermely, Péter; Korcsmáros, Tamás (2013)

Cancer is increasingly described as a systems-level, network phenomenon. Genetic methods, such as next generation sequencing and RNA interference uncovered the complexity tumor-specific mutation-induced effects and the ...
Cancer stem cells display extremely large evolvability alternating plastic and rigid networks as a potential mechanism Network models, novel therapeutic target strategies, and the contributions of hypoxia, inflammation and cellular senescence

Csermely, Péter; Hodsagi J,; Korcsmáros, Tamás; Módos, Dezső; Perez-Lopez AR,; Szalay, Kristóf Zsolt; Veres, Dániel; Földvári-Nagy Lászlóné Lenti, Katalin (2015)

Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by ...
Complex regulation of autophagy in cancer - integrated approaches to discover the networks that hold a double-edged sword

Kubisch J; Türei, Dénes; Földvári-Nagy, László; Dunai ZA; Zsakai L; Varga, Máté; Vellai, Tibor; Csermely, Péter; Korcsmáros, Tamás (2013)

Autophagy, a highly regulated self-degradation process of eukaryotic cells, is a context-dependent tumor-suppressing mechanism that can also promote tumor cell survival upon stress and treatment resistance. Because of this ...
ComPPI: a cellular compartment-specific database for protein-protein interaction network analysis

Veres, Dániel; Gyurkó, Márton Dávid; Thaler B; Szalay, Kristóf Zsolt; Fazekas, Dávid; Korcsmáros, Tamás; Csermely, Péter (2015)

Here we present ComPPI, a cellular compartment-specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network analysis (URL: http://ComPPI.LinkGroup.hu). ...
Discovering cooperative biomarkers for heterogeneous complex disease diagnoses

Sun, Duanchen; Xianwen, Ren; Ari, Eszter; Korcsmáros, Tamás; Csermely, Péter; Ling-Yun, Wu (2019)

Biomarkers with high reproducibility and accurate prediction performance can contribute to comprehending the underlying pathogenesis of related complex diseases and further facilitate disease diagnosis and therapy. ...
Identification of critical paralog groups with indispensable roles in the regulation of signaling flow

Módos, Dezső; Brooks J; Fazekas D; Ari, Eszter; Vellai, Tibor; Csermely, Péter; Korcsmáros, Tamás; Földvári-Nagy Lászlóné Lenti, Katalin (2016)

Extensive cross-talk between signaling pathways is required to integrate the myriad of extracellular signal combinations at the cellular level. Gene duplication events may lead to the emergence of novel functions, leaving ...
NRF2-ome: An integrated web resource to discover protein interaction and regulatory networks of NRF2

Türei, Dénes; Papp, Diána; Fazekas, Dávid; Földvári-Nagy, László; Módos, Dezső; Földvári-Nagy Lászlóné Lenti, Katalin; Csermely, Péter; Korcsmáros, Tamás (2013)

NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses. NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. We developed an online resource, NRF2-ome, ...
SignaFish: A Zebrafish-Specific Signaling Pathway Resource

Csalyi K,; Fazekas, Dávid; Kadlecsik, Tamás; Turei D,; Gul L,; Módos, Dezső; Demeter, Amanda; Földvári-Nagy Lászlóné Lenti, Katalin; Csermely, Péter; Vellai, Tibor; Korcsmáros, Tamás; Varga, Máté (2016)

Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources ...
SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks

Fazekas D,; Koltai M,; Türei, Dénes; Módos, Dezső; Palfy M,; Dúl, Zoltán; Zsákai, Lilian; Földvári-Nagy Lászlóné Lenti, Katalin; Farkas, Illés; Vellai, Tibor; Csermely, Péter; Korcsmáros, Tamás (2013)

ABSTRACT: BACKGROUND: Signaling networks in eukaryotes are made up of upstream and downstream subnetworks. The upstream subnetwork contains the intertwined network of signaling pathways, while the downstream regulatory ...
Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites

Földvári-Nagy, László; Ari, Eszter; Csermely, Péter; Korcsmáros, Tamás; Vellai, Tibor (2014)

Autophagy, the lysosome-mediated self-degradation process, is implicated in survival during starvation in yeast, Dictyostelium and animals. In these eukaryotic taxa (collectively called Unikonts), autophagy is induced ...
Structure and dynamics of molecular networks: A novel paradigm of drug discovery. A comprehensive review

Csermely, Péter; Korcsmáros, Tamás; Kiss, Huba; London, Gábor; Nussinov R (2013)
Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress

Kosztelnik, Mónika; Kurucz, Anita; Papp, Diána; Jones, Emily; Kovácsné Sigmond, Tímea Ilona; Barna, János; Traka Maria, H; Lőrincz, Tamás; Szarka, András; Bánhegyi, Gábor; Vellai, Tibor; Korcsmáros, Tamás; Kapuy, Orsolya (2019)

NF-E2-related factor 2 (NRF2) transcription factor has a fundamental role in cell homeostasis maintenance as one of the master regulators of oxidative and electrophilic stress responses. Previous studies have shown that a ...
Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

Perez-Lopez ÁR; Szalay KZ; Türei D; Módos D; Földvári-Nagy Lászlóné Lenti, Katalin; Korcsmáros, Tamás; Csermely, Péter (2015)
Teaching the bioinformatics of signaling networks: an integrated approach to facilitate multi-disciplinary learning

Korcsmáros, Tamás; Dunai Zsuzsanna A; Vellai, Tibor; Csermely, Péter (2013)

The number of bioinformatics tools and resources that support molecular and cell biology approaches is continuously expanding. Moreover, systems and network biology analyses are accompanied more and more by integrated ...

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tallózása szerző szerint "Korcsmáros, Tamás"

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