tallózása szerző szerint "Pálóczi, János"

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Activation of PPARbeta/delta protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen/nitrogen species and expression of matrix metalloproteinases

Barlaka E; Görbe, Anikó; Gáspár, Renáta; Pálóczi, János; Ferdinandy, Péter; Lazou A (2015)

Heart failure still remains one of the leading causes of morbidity and mortality worldwide. A major contributing factor is reactive oxygen/nitrogen species (RONS) overproduction which is associated with cardiac remodeling ...
Adverse Effects on beta-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function

Schreckenberg R; Bencsik, Péter; Weber M; Abdallah Y; Csonka, Csaba; Gömöri, Kamilla; Kiss, Krisztina; Pálóczi, János; Pipis J; Sárközy, Márta; Ferdinandy, Péter; Schulz R; Schluter KD (2017)

BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and ...
Cardioprotection by Farnesol: Role of the Mevalonate Pathway

Szűcs, Gergő; Murlasits, Zsolt; Török, Szilvia; Kocsis-Fodor, Gabriella; Pálóczi, János; Görbe, Anikó; Csont, Tamás Bálint; Csonka, Csaba; Ferdinandy, Péter (2013)

Purpose: Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart. Methods: Male Wistar rats were treated orally with 0.2, 1, ...
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide

Csonka, Csaba; Kupai, Krisztina; Bencsik, Péter; Görbe, Anikó; Pálóczi, János; Zvara, Ágnes; Puskás, László; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

It has been previously shown that hyperlipidemia interferes with cardioprotective mechanisms. Here we investigated the interaction of hyperlipidemia with cardioprotection induced by pharmacological activators of ATP-sensitive ...
Cytoprotection by the NO-donor SNAP against ischemia/reoxygenation injury in mouse embryonic stem cell-derived cardiomyocytes

Görbe, Anikó; Varga, Zoltán; Pálóczi, János; S. Rungarunlert; N. Klincumhom; Pirity, Melinda; R. Madonna; T. Eschenhagen; Dinnyés, András; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

Embryonic stem cell (ESC)-derived cardiomyocytes are a promising cell source for the screening for potential cytoprotective molecules against ischemia/reperfusion injury, however, little is known on their behavior ...
Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

Bencsik, Péter; Kupai, Krisztina; Görbe, Anikó; Kenyeres, Éva; Varga, Zoltán; Pálóczi, János; Gáspár, Renáta; Kovács László; Lutz Weber; Takács Ferenc; Hajdú, István; Fabó Gabriella; Cseh, Sándor; Barna, László; Csont, Tamás; Csonka, Csaba; Dormán, György; Ferdinandy, Péter (2018)

The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and ...
Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury

Pálóczi, János; Varga, Zoltán V; Apáti, Ágota; Szebényi, Kornélia; Sarkadi, Balázs; Rosalinda, Madonna; Raffaele, De Caterina; Csont, Tamás Bálint; Thomas, Eschenhagen; Ferdinandy, Péter; Görbe, Anikó (2016)

Background and Aims. Human embryonic stem cell- (hESC-) derived cardiomyocytes are one of the useful screening platforms of potential cardiocytoprotective molecules. However, little is known about the behavior of these ...
JDP2 overexpression provokes cardiac dysfunction in mice

Heger J; Bornbaum J; Wurfel A; Hill C; Brockmann N; Gáspár, Renáta; Pálóczi, János; Varga, Zoltán; Sárközy, Márta; Bencsik, Péter; Csont, Tamás Bálint; Török, Szilvia; Kojonazarov B; Schermuly RT; Bongler K; Parahuleva M; Ferdinandy, Péter; Schulz R; Euler G (2018)

The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing ...
Lack of Contribution of p66shc and Its Mitochondrial Translocation to Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Preconditioning

Boengler K; Bencsik, Péter; Pálóczi, János; Kiss, Krisztina; Pipicz, Márton; Pipis J; Ferdinandy, Péter; Schluter KD; Schulz R (2017)

Whereas high amounts of reactive oxygen species (ROS) contribute to cardiac damage following ischemia and reperfusion (IR), low amounts function as trigger molecules in the cardioprotection by ischemic preconditioning ...
MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

Varga, Zoltán; Kupai, Krisztina; Szűcs, Gergő; Gáspár, Renáta; Pálóczi, János; Faragó, Nóra; Zvara, Ágnes; Puskás, László; Rázga, Zsolt; Tiszlavicz, László; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Ferdinandy, Péter; Csont, Tamás Bálint (2013)

Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether ...
MMP Activity Detection in Zymograms

Bencsik, Péter; Bartekova M; Görbe, Anikó; Kiss, Krisztina; Pálóczi, János; Szűcs, Gergő; Ferdinandy, Péter (2017)

Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative tool for determining the activity of different MMP isoenzymes in a variety of biological ...
Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective

Bencsik, Péter; Pálóczi, János; Kocsis-Fodor, Gabriella; Pipis, Judit; Belecz, István; Varga, Zoltán; Csonka, Csaba; Görbe, Anikó; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered ...
Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats

Kiss, Krisztina; Csonka, Csaba; Pálóczi, János; Pipis, Judit; Görbe, Anikó; Kocsis-Fodor, Gabriella; Murlasits Z; Sárközy, Márta; Szűcs, Gergő; Holmes CP; Pan Y; Bhandari A; Csont, Tamás Bálint; Shamloo M; Woodburn KW; Ferdinandy, Péter; Bencsik, Péter (2016)

Erythropoietin (EPO) has been shown to protect the heart against acute myocardial infarction in pre-clinical studies, however, EPO failed to reduce infarct size in clinical trials and showed significant safety problems. ...
Protection by the NO-Donor SNAP and BNP against Hypoxia/Reoxygenation in Rat Engineered Heart Tissue

Görbe, Anikó; Eder A; Varga, Zoltán; Pálóczi, János; Hansen A; Ferdinandy, Péter; Eschenhagen T (2015)

In vitro assays could replace animal experiments in drug screening and disease modeling, but have shortcomings in terms of functional readout. Force-generating engineered heart tissues (EHT) provide simple automated ...

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tallózása szerző szerint "Pálóczi, János"

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