tallózása szerző szerint "Paku, Sándor"

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ABCC6 is a basolateral plasma membrane protein

Pomozi, Viola; Le Saux, O; Brampton, C; Apana, A; Iliás, Attila; Szeri, Flóra; Martin, L; Monostory, Katalin; Paku, Sándor; Sarkadi, Balázs; Szakács, Gergely; Váradi, András (2013)

RATIONALE:: ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy. To elucidate the role of ABCC6 in cellular physiology and ...
Alterations in Hepatic Lobar Function in Regenerating Rat Liver

Fülöp, András; Budai, András; Czigány, Zoltán; Lotz, Gábor; Dezső, Katalin; Paku, Sándor; Harsányi, László; Szijártó, Attila (2015)
Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications

Döme, Balázs; Hendrix, Mary JC; Paku, Sándor; Tóvári, József; Tímár, József (2007)

Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor growth is highly dependent on the supply of oxygen, nutrients, and host-derived regulators. It is now established that tumor vasculature ...
A New Mechanism for Pillar Formation during Tumor-Induced Intussusceptive Angiogenesis

Paku, Sándor; Dezső, Katalin; Bugyik, Edina; Tóvári, József; Tímár, József; Nagy, Péter; Laszlo, Viktoria; Klepetko W; Döme, Balázs (2011)

One of the hallmarks of intussusceptive angiogenesis is the development of intraluminal connective tissue pillars. The exact mechanism of pillar formation has not yet been elucidated. By using electron and confocal microscopy, ...
Apelin expression in human non-small cell lung cancer: Role in angiogenesis and prognosis

Berta, Judit; Kenessey, István; Dobos J; Tóvári, József; Klepetko W; Ankersmit HJ; Hegedűs, Balázs; Rényi-Vámos, Ferenc István; Varga, János; Lorincz Zs; Paku, Sándor; Ostoros, Gyula; Rózsás, Anita; Tímár, József; Döme, Balázs (2010)
Apelin promotes lymphangiogenesis and lymph node metastasis

Berta, Judit; Hoda MA; Laszlo, Viktoria; Rozsas A; Garay, Tamás; Torok S; Grusch M; Berger W; Paku, Sándor; Rényi-Vámos, Ferenc István; Masri B; Tóvári, József; Groger M; Klepetko W; Hegedűs, Balázs; Döme, Balázs (2014)

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been ...
Boyden chamber-based method for characterizing the distribution of adhesions and cytoskeletal structure in HT1080 fibrosarcoma cells

Tóvári, József; Futosi, Krisztina; Bartal A; Tátrai, Enikő; Gacs A; Kenessey, István; Paku, Sándor (2014)
Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic haematopoietic cells in cancer: From biology to therapy

Döme, Balázs; Tímár, József; Ladányi, Andrea; Paku, Sándor; Rényi-Vámos, Ferenc István; Klepetko, Walter; Lang, György; Döme, Péter; Bogos, Krisztina; Tóvári, József (2009)

Vascularization, a hallmark of tumorigenesis, is classically thought to occur exclusively through angiogenesis (i.e. endothelial sprouting). However, there is a growing body of evidence that endothelial progenitor cells ...
Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

Dezső, Katalin; Halász, Judit; Bisgaard HC,; Paku, Sándor; Turányi, Eszter; Schaff, Zsuzsa; Nagy, Péter (2008)

Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the ...
Development of arterial blood supply in experimental liver metastases

Dezső, Katalin; Bugyik, Edina; Papp, Veronika; Laszlo, Viktoria; Döme, Balázs; Tóvári, József; Tímár, József; Nagy, Péter; Paku, Sándor (2009)
Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models

Rókusz, András; Veres, Dániel; Szücs, Armanda; Bugyik, Edina; Mózes, Miklós; Paku, Sándor; Nagy, Péter; Dezső, Katalin (2017)

BACKGROUND AND AIMS: Ductular reaction is a standard component of fibrotic liver tissue but its function is largely unknown. It is supposed to interact with the matrix producing myofibroblasts and compensate the declining ...
Ectopic alpha IIb beta 3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells

Rásó, Erzsébet; Tóvári, József; Tóth, Krisztina; Paku, Sándor; Trikha, Mohit; Kenneth, V. Honn; Tímár, József (2001)

Megakaryocytic genes such as alpha IIb beta3 can be expressed by malignant cells as part of the disturbances in their gene regulation. However, the function of the gene product greatly depends on the interaction of ...
Enhancer of zeste homologue 2 (EZH2) is a reliable immunohistochemical marker to differentiate malignant and benign hepatic tumors

Hajosi-Kalcakosz S; Dezső, Katalin; Bugyik, Edina; Bödör, Csaba; Paku, Sándor; Pavai Z; Halász, Judit; Schlachter, Krisztina; Schaff, Zsuzsa; Nagy, Péter (2012)

BACKGROUND: The immunohistochemical demonstration of Enhancer of zeste homologue 2 (EZH2) proved to be a useful marker in several tumor types. It has been described to distinguish reliably hepatocellular carcinomas from ...
Expansion of Hepatic Stem Cell Compartment Boosts Liver Regeneration.

Papp, Veronika; Rókusz, András; Dezső, Katalin; Bugyik, Edina; Szabó, Vanessza; Paku, Sándor; Nagy, Péter (2014)

The hepatic stem cells reside periportally forming the canals of Hering in normal liver. They can be identified by their unique immunophenotype in rat. The oval cells, the progenies of stem cells invade deep the liver ...
EZH2 is a sensitive marker of malignancy in salivary gland tumors

Hajosi-Kalcakosz S; Vincze E; Dezső, Katalin; Paku, Sándor; Rókusz, András; Sápi, Zoltán; Tóth, Erika; Nagy, Péter (2015)

BACKGROUND: The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of ...
Imatinib accelerates progenitor cell-mediated liver regeneration in choline-deficient ethionine-supplemented diet-fed mice

Rókusz, András; Bugyik, Edina; Szabó, Vanessza; Szücs, Armanda; Paku, Sándor; Nagy, Péter; Dezső, Katalin (2016)

Severe chronic hepatic injury can induce complex reparative processes. Ductular reaction and the appearance of small hepatocytes are standard components of this response, which is thought to have both adverse (e.g. fibrosis, ...
Lack of Angiogenesis in Experimental Brain Metastases

Bugyik, Edina; Dezső, Katalin; Reiniger, Lilla; Laszlo, Viktoria; Tóvári, József; Tímár, József; Nagy, Péter; Klepetko W; Döme, Balázs; Paku, Sándor (2011)

Angiogenesis is believed to be essential for the growth of metastatic tumors in the brain. We analyzed the vascularization of tumors formed by 4 epithelial cell lines (C38, ZR75, HT25, and H1650) and a fibrosarcoma (HT1080) ...
Localization of sunitinib, its metabolites and its target receptors in tumour bearing mice: a MALDI mass spectrometry imaging study

Török, Szilvia; Vegvari A; Rezeli M; Fehniger TE; Tóvári, József; Paku, Sándor; Laszlo, Viktoria; Hegedűs, Balázs; Rózsás, Anita; Döme, Balázs; Marko-Varga G (2015)

BACKGROUND AND PURPOSE: The clinical impact of antiangiogenic agents remains controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue. EXPERIMENTAL APPROACH: In our study, ...
Mechanism of tumour vascularisation in experimental lung metastases

Szabó, Vanessza; Bugyik, Edina; Dezső, Katalin; Ecker N; Nagy, Péter; Tímár, József; Tóvári, József; Laszlo, Viktoria; Bridgeman VL; Wan E; Frentzas S; Vermeulen PB; Reynolds AR; Döme, Balázs; Paku, Sándor (2015)

The appearance of lung metastases is associated with poor outcome and the management of patients with secondary pulmonary tumours remains a clinical challenge. We examined the vascularisation process of lung metastasis in ...
Mechanisms of vascularization in murine models of primary and metastatic tumor growth

Bugyik, Edina; Rényi-Vámos, Ferenc István; Szabó, Vanessza; Dezső, Katalin; Ecker N; Rókusz, András; Nagy, Péter; Döme, Balázs; Paku, Sándor (2016)

Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant ...

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