tallózása szerző szerint "Periyasamy M"

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APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

Periyasamy M; Patel H; Lai CF; Nguyen VT; Nevedomskaya E; Harrod A; Russell R; Remenyi J; Ochocka AM; Thomas RS; Fuller-Pace F; Győrffy, Balázs; Caldas C; Navaratnam N; Carroll JS; Zwart W; Coombes RC; Magnani L; Buluwela L; Ali S (2015)

Estrogen receptor alpha (ERalpha) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U ...
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Nguyen VTM; Barozzi I; Faronato M; Lombardo Y; Steel JH; Patel N; Darbre P; Castellano L; Győrffy B; Woodley L; Meira A; Patten DK; Vircillo V; Periyasamy M; Ali S; Frige G; Minucci S; Coombes RC; Magnani L (2015)

Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we ...
Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor-positive breast cancer

Patel H; Abduljabbar R; Lai CF; Periyasamy M; Harrod A; Gemma C; Steel J; Patel N; Busonero C; Jerjees D; Remenyi J; Smith S; Gomm JJ; Magnani L; Győrffy, Balázs; Jones JL; Fuller-Pace FV; Shousha S; Buluwela L; Rakha EA; Ellis IO; Coombes RC; Ali S (2016)

PURPOSE: CDK-activation kinase (CAK) is required for the regulation of the cell-cycle and is a trimeric complex consisting of Cyclin Dependent Kinase 7 (CDK7), Cyclin H and the accessory protein, MAT1. CDK7 also plays a ...

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tallózása szerző szerint "Periyasamy M"

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tallózása szerző szerint "Periyasamy M"

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