tallózása szerző szerint "Sebestyén, Anna"

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Activity and complexes of mTOR in diffuse large B-cell lymphomas-a tissue microarray study

Sebestyén, Anna; Sticz TB; Márk, Ágnes; Hajdu, Melinda; Tímár, Botond; Nemes, Karolina; Nagy, Noémi; Váradi, Zsófia; Kopper, László (2012)

Diffuse large B-cell lymphoma is a heterogeneous group of diseases with different responses to therapy. Targeting mTOR (mammalian target of rapamycin) offers a new approach to improve the treatment. mTOR inhibitors are ...
Characterisation of bioenergetic pathways and related regulators by multiple assays in human tumour cells

Jeney, András; Hujber, Zoltán; Szoboszlai, Norbert; Fullár, Alexandra; Oláh, Lászlóné; Pap É; Márk, Ágnes; Kriston, Csilla; Kralovánszky, Judit; Kovalszky, Ilona; Vékey, Károly; Sebestyén, Anna (2016)

Background: Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to ...
Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease - a combined tissue microarray, in vitro and in vivo study.

Márk, Ágnes; Hajdu, Melinda; Varadi Z; Sticz TB; Nagy, Noémi; Csomor, Judit; Berczi L; Varga V; Csóka, Monika; Kopper, László; Sebestyén, Anna (2013)

BACKGROUND: Targeting signaling pathways is an attractive approach in many malignancies. The PI3K/Akt/mTOR pathway is activated in a number of human neoplasms, accompanied by lower overall and/or disease free survival. ...
Discrepancy Between Low Levels of mTOR Activity and High Levels of P-S6 in Primary Central Nervous System Lymphoma May Be Explained by PAS Domain-Containing Serine/Threonine-Protein Kinase-Mediated Phosphorylation

Marosvári, Dóra; Nagy, Noémi; Kriston, Csilla; Deak B; Hajdu, Melinda; Bödör, Csaba; Csala, Irén; Bago AG; Szállási, Zoltán; Sebestyén, Anna; Reiniger, Lilla (2018)

The primary aim of this study was to determine mTOR-pathway activity in primary central nervous system lymphoma (PCNSL), which could be a potential target for therapy. After demonstrating that p-S6 positivity largely ...
Expression of certain leukemia/lymphoma related microRNAs and its correlation with prognosis in childhood acute lymphoblastic leukemia

Nemes, Karolina; Csóka, Monika; Nagy, Noémi; Márk, Ágnes; Zsófia Váradi; Titanilla Dankó; Kovács, Gábor; Kopper, László; Sebestyén, Anna (2015)
Expression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma

Krencz, Ildikó; Sebestyén, Anna; Fábián, Katalin; Márk, Ágnes; Moldvay, Judit; Khoor A; Kopper, László; Pápay, Judit (2017)

Brain metastases are common complications of adenocarcinomas of the lung and are associated with a poor prognosis. Although an increasing amount of data indicates that dysregulated activity of mammalian target of rapamycin ...
Extracellular Vesicle-Based Communication May Contribute to the Co-Evolution of Cancer Stem Cells and Cancer-Associated Fibroblasts in Anti-Cancer Therapy

Valcz, Gábor; Buzás, Edit Irén; Sebestyén, Anna; Krenács, Tibor; Szállási, Zoltán; Igaz, Péter; Molnár, Béla (2020)
Extracellular Vesicle-Mediated Metastasis Suppressors NME1 and NME2 Modify Lipid Metabolism in Fibroblasts.

Mátyási, Barbara; Petővári, Gábor; Dankó, Titanilla; Butz, Henriett; Likó, István; Lőw, Péter; Petit, Isabelle; Bittar, Randa; Bonnefont-Rousselot, Dominique; Farkas, Zsolt; Szeniczey, Tamás; Molnár, Kinga; Palóczi, Krisztina; Buzás, Edit I; Boissan, Mathieu; Sebestyén, Anna; Takács-Vellai, Krisztina (2022)

Nowadays, extracellular vesicles (EVs) raise a great interest as they are implicated in intercellular communication between cancer and stromal cells. Our aim was to understand how vesicular NME1 and NME2 released by breast ...
GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

Hujber, Zoltán; Horváth, Gergő; Petővári, Gábor; Krencz, Ildikó; Dankó, Titanilla; Mészáros, Katalin; Rajnai, Hajnalka; Szoboszlai, Norbert; Leenders William PJ; Jeney, András; Tretter, László; Sebestyén, Anna (2018)

Bioenergetic characterisation of malignant tissues revealed that different tumour cells can catabolise multiple substrates as salvage pathways, in response to metabolic stress. Altered metabolism in gliomas has received a ...
Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation

Nagy, Noémi; Hajdu, Melinda; Márk, Ágnes; Király, Péter Attila; Toth M; Danko T; Csóka, Monika; Sebestyén, Anna (2016)

Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and ...
Heparin can liberate high molecular weight DNA from secondary necrotic cells

Barna, Gábor; Sebestyén, Anna; Dunai, Zsuzsanna; Csernus, Balázs; Mihalik, Rudolf (2012)

The border-line between necrosis and apoptosis is not sharp, but the distinction between types of cell death is important, because necrosis may lead to local inflammation, while apoptosis usually does not. In certain ...
Kezdeti tapasztalataink a petefészekszövet-fagyasztás bevezetésével. [First attempts in the introduction of cryopreservation of ovarian tissues]

Fancsovits, Péter; Urbancsek, János Attila; Fónyad, László; Sebestyén, Anna; Csorba G; Lehner, Ádám; Kaszás, Zita; Rigó, János; Bokor, Attila (2016)

INTRODUCTION: The oncological treatment may damage ovarian function. To prevent this, it is possible to cryopreserve the ovarian tissue, and to keep the samples for long-term storage. The frozen-thawed tissue could be ...
mTOR Pathway As a Potential Target In a Subset of Human Medulloblastoma.

Pócza, Tímea; Sebestyén, Anna; Turányi, Eszter; Krenács, Tibor; Márk, Ágnes; Sticz TB; Jakab, Zsuzsanna; Hauser, Péter (2014)

As mammalian Target of Rapamycin (mTOR) plays role in protein synthesis and metabolism, mTOR pathway activation is involved in the pathogenesis of several types of tumors. Our aim was to elucidate its role in medulloblastoma ...
Rapamycin can restore the negative regulatory function of transforming growth factor beta 1 in high grade lymphomas

Sebestyén, Anna; Márk, Ágnes; Hajdu, Melinda; Nagy, Noémi; Molnár A; Végső, Gyula; Barna, Gábor; Kopper, László (2015)
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

Hujber, Zoltán; Petővári, Gábor; Szoboszlai, Norbert; Danko T; Nagy, Noémi; Kriston, Csilla; Krencz, Ildikó; Paku, Sándor; Ozohanics, Olivér; Drahos, László; Jeney, András; Sebestyén, Anna (2017)

BACKGROUND: Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms ...
The density of CD8+ T-cell infiltration and expression of BCL2 predicts outcome of primary diffuse large B-cell lymphoma of bone

Rajnai, Hajnalka; Heyning FH; Koens L; Sebestyén, Anna; Andrikovics, Hajnalka; Hogendoorn PCW; Matolcsy, András; Szepesi, Ágota (2014)
Versatility of microglial bioenergetic machinery under starving conditions

Nagy, Ádám Miklós; Fekete, Rebeka; Horváth, Gergő; Koncsos, Gábor; Kriston, Csilla; Sebestyén, Anna; Giricz, Zoltán; Környei, Zsuzsanna; Madarász, Emília; Tretter, László (2018)

Microglia are highly dynamic cells in the brain. Their functional diversity and phenotypic versatility brought microglial energy metabolism into the focus of research. Although it is known that microenvironmental cues shape ...

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tallózása szerző szerint "Sebestyén, Anna"

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