tallózása szerző szerint "Tóthfalusi László"

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Acute escitalopram treatment inhibits REM sleep rebound and activation of MCH-expressing neurons in the lateral hypothalamus after long term selective REM sleep deprivation.

Kátai Zita; Ádori Csaba; Kitka Tamás; Vas Szilvia; Kalmar L; Kostyalik Diána; Tóthfalusi László; Palkovits Miklós; Bagdy György (2013)

RATIONALE: Selective rapid eye movement sleep (REMS) deprivation using the platform-on-water ("flower pot") method causes sleep rebound with increased REMS, decreased REMS latency, and activation of the melanin-concentrating ...
A krónikus escitalopram kezelés hatása a vigilanciára és a kvantitatív EEG-re REM-megvonás és akut 5-HT2C receptor antagonista adagolása után

Kostyalik, Diána (2016)
Approvable generic carbamazepine formulations may not be bioequivalent in target patient populations.

Tóthfalusi László; Endrenyi L (2013)

OBJECTIVES: To demonstrate that with carbamazepine (CBZ), positive results of bioequivalence trials in healthy volunteers cannot be extrapolated to patients because metabolic enzyme induction fundamentally changes the ...
Chronic escitalopram treatment attenuated the accelerated rapid eye movement sleep transitions after selective rapid eye movement sleep deprivation: a model-based analysis using Markov chains

Kostyalik Diána; Vas Szilvia; Kátai Zita; Kitka Tamás; Gyertyán István; Bagdy György; Tóthfalusi László (2014)

BackgroundShortened rapid eye movement (REM) sleep latency and increased REM sleep amount are presumed biological markers of depression. These sleep alterations are also observable in several animal models of depression ...
Chronic escitalopram treatment caused dissociative adaptation in serotonin (5-HT) 2C receptor antagonist-induced effects in REM sleep, wake and theta wave activity.

Kostyalik Diána; Kátai Zita; Vas Szilvia; Pap Dorottya; Petschner Péter; Molnár Eszter; Kalmár Lajos; Tóthfalusi László; Bagdy György (2014)

Several multi-target drugs used in treating psychiatric disorders, such as antidepressants (e.g. agomelatine, trazodone, nefazodone, amitriptyline, mirtazapine, mianserin, fluoxetine) or most atypical antipsychotics, have ...
Determination of bioequivalence for drugs with narrow therapeutic index

Endrenyi L; Tóthfalusi László (2013)

The US Food and Drug Administration (FDA) has recently suggested that the bioequivalence (BE) for products of drugs with narrow therapeutic indices (NTI) be assessed by the approach of reference-scaled average BE (SABE). ...
Effect of a Single Neonatal Oxytocin Treatment (Hormonal Imprinting) on the Biogenic Amine Level of the Adult Rat Brain: Could Oxytocin-Induced Labor Cause Pervasive Developmental Diseases?

FARZAD HASHEMI; Tekes Kornélia; Laufer Rudolf; Szegi Péter; Tóthfalusi László; Csaba György (2013)

Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats ...
Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats.

Petschner Péter; Tamási Viola; Ádori Csaba; Kirilly Eszter; Andó Rómeó; Tóthfalusi László; Bagdy György (2018)

BACKGROUND: 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established ...
On the interchangeability of biologic drug products.

Endrenyi L; Chang C; Chow SC; Tóthfalusi László (2013)

Interchangeability of drug products has very different features with small molecules and with biologicals. With small-molecule drugs, a statement of bioequivalence generally indicates therapeutic equivalence and ...
Statistical and regulatory considerations in assessments of interchangeability of biological drug products.

Tóthfalusi László; Endrenyi L; Chow SC (2014)

When the patent of a brand-name, marketed drug expires, new, generic products are usually offered. Small-molecule generic and originator drug products are expected to be chemically identical. Their pharmaceutical similarity ...

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