http://repo.lib.semmelweis.hu//handle/123456789/26 2026-09-28T13:01:12Z http://repo.lib.semmelweis.hu//handle/123456789/10454 Adatvezérelt biztoság a diabetológiában Tóth-Heyn, Péter 2026-01-01T00:00:00Z http://repo.lib.semmelweis.hu//handle/123456789/10453 A hátsó húgycsőbillentyű korszerű ellátása Tallós, Zsuzsa; Nagy, Csilla; Antal, Zsuzsanna A hátsó húgycsõbillentyû ritka, fiúgyermekeket érintõ fejlõdési rendellenesség. Másodlagosan több szervrendszer károsodását okozhatja, mely miatt élethosszig tartó gondozást igényel. A betegek harmadában krónikus vesebetegséghez vezet. Ellátásában, gondozásában évrõl évre újabb szemléletek, lehetõségek jelennek meg. Közleményünkben összefoglaljuk a jelenleg érvényes kezelési javaslatokat az Európai Urológiai Társaság 2025-ös ajánlását véve alapul, hangsúlyozva a hazánkban elfogadott elveket 2026-01-01T00:00:00Z http://repo.lib.semmelweis.hu//handle/123456789/10452 Novel seco-dammarane triterpenes with antimicrobial activity against plant pathogens from Ailanthus altissima petioles Cselőtey, Anna; Baglyas, Márton; Aschenbrenner, Panna; Bozsó, Zoltán; Schwarczinger, Ildikó; Bakonyi, József; Darcsi, András; Glavnik, Vesna; Vovk, Irena; Móricz, Ágnes M. There is a growing demand for effective, environmentally friendly pesticides due to increasing environmental awareness and stricter regulations on chemical use. Natural products, including secondary metabolites of the invasive tree of heaven ( Ailanthus altissima ), could represent promising sources for biopesticide development. A bioassay-guided isolation workflow involving thin-layer chromatography (TLC)– Bacillus subtilis bioassay, TLC–high-resolution mass spectrometry (HRMS), and preparative flash column chromatography yielded three antimicrobial seco -dammarane triterpenes from the methanolic extract of A. altissima petioles, namely the known shoreic acid ( 1 ), and the previously undescribed foveolin C ( 2 ), and (20 S ,24 R )-epoxy-25-hydroxy-A-homo-4-oxadammaran-3-one ( 3 ). Their structures were elucidated by nuclear magnetic resonance (NMR) spectroscopy, supported by high-resolution tandem mass spectrometry (HRMS/MS) and polarimetry. The presence of the hydroxylated, polyunsaturated fatty acids 13-hydroxy-9,11-octadecadienoic acid (13-HODE, 4 ) and 9-hydroxy-10,12-octadecadienoic acid (9-HODE, 5 ), previously isolated from A. altissima bark, was also confirmed in the petioles by high-performance liquid chromatography (HPLC)–HRMS/MS. To the best of our knowledge, compounds 2 and 3 are reported here as new natural products, while compounds 1 , 4 , and 5 were detected in A. altissima petioles for the first time. In microdilution assays, compounds 1 – 5 showed antimicrobial activity against B. subtilis , the plant pathogenic bacteria Curtobacterium flaccumfaciens pv. flaccumfaciens , Clavibacter michiganensis , and Rhodococcus fascians , as well as the plant pathogenic fungus Fusarium graminearum . Compound 1 exhibited the strongest antibacterial activity, especially against C. michiganensis and R. fascians , with minimal inhibitory concentration (MIC) values two-fold lower than those of the positive control neomycin. Compounds 2 – 5 were the most effective against R. fascians , with MIC values the same as or two-fold higher than those of neomycin. These results indicate that A. altissima petioles represent a promising source of antimicrobial phytochemicals. After proper structure optimization, they could serve as lead compounds for the development of novel antimicrobial agents against certain phytopathogens. 2026-01-01T00:00:00Z http://repo.lib.semmelweis.hu//handle/123456789/10450 Novel Antioxidant Caffeate Esters of Black Locust (Robinia pseudoacacia L.) Stem Bark Móricz, Ágnes M.; Cselőtey, Anna; Baglyas, Márton Antioxidant profiling of black locust (Robinia pseudoacacia L.) stem bark was performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay off-line coupled to high-performance liquid chromatography–diode array detection–electrospray ionization mass spectrometry (DPPH–HPLC–DAD–ESI–QMS). The ethyl acetate, methanol, and n-hexane extracts exhibited similar chemical profiles for the antioxidant amphipathic phenolic compounds; however, the ethyl acetate extract was the richest in them, and n-hexane yielded several compounds in higher ratios. A total of 21 compounds displayed antioxidant activity and were further characterized by HPLC–high-resolution tandem MS (HRMS/MS). Nine compounds were identified as previously described antioxidants from the black locust stem bark, including 3-O-caffeoyl oleanolic acid (1), and the oleyl (4), octadecyl (6), gadoleyl (7), eicosanyl (9), (Z)-9-docosenyl (10), docosyl (12), tetracosyl (15), and hexacosyl (17) caffeates. Further ten caffeate and two ferulate esters were tentatively identified as 3-O-caffeoyl oleanolic, ursolic, or betulinic aldehyde (2), and hexadecyl (3), heptadecyl (5), hydroxy-hexacosyl (8), henicosyl (11), tetracosenyl (13), tricosyl (14), hexacosenyl (16), octacosenyl (18), and octacosyl (20) caffeates, and hexacosyl (19) and octacosyl (21) ferulates that were reported for the first time in R. pseudoacacia. Furthermore, this is the first report about the antioxidant activity of the previously undescribed compounds 8, 13, 16, and 18, as well as known compounds 11 and 14. 2026-01-01T00:00:00Z