MTMT-ben szereplő publikációk tallózása szerző szerint "Coombes RC"

A találatok rendezése: Rendezés: Találatok:

  • APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer 
    Periyasamy M; Patel H; Lai CF; Nguyen VT; Nevedomskaya E; Harrod A; Russell R; Remenyi J; Ochocka AM; Thomas RS; Fuller-Pace F; Győrffy, Balázs; Caldas C; Navaratnam N; Carroll JS; Zwart W; Coombes RC; Magnani L; Buluwela L; Ali S (2015)
    Estrogen receptor alpha (ERalpha) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U ...
  • Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion 
    Nguyen VTM; Barozzi I; Faronato M; Lombardo Y; Steel JH; Patel N; Darbre P; Castellano L; Győrffy B; Woodley L; Meira A; Patten DK; Vircillo V; Periyasamy M; Ali S; Frige G; Minucci S; Coombes RC; Magnani L (2015)
    Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we ...
  • Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer 
    Patten DK; Corleone G; Győrffy, Balázs; Perone Y; Slaven N; Barozzi I; Erdős, Edina; Saiakhova A; Goddard K; Vingiani A; Shousha S; Pongor, Lőrinc; Hadjiminas DJ; Schiavon G; Barry P; Palmieri C; Coombes RC; Scacheri P; Pruneri G; Magnani L (2018)
    The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific ...
  • Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor-positive breast cancer 
    Patel H; Abduljabbar R; Lai CF; Periyasamy M; Harrod A; Gemma C; Steel J; Patel N; Busonero C; Jerjees D; Remenyi J; Smith S; Gomm JJ; Magnani L; Győrffy, Balázs; Jones JL; Fuller-Pace FV; Shousha S; Buluwela L; Rakha EA; Ellis IO; Coombes RC; Ali S (2016)
    PURPOSE: CDK-activation kinase (CAK) is required for the regulation of the cell-cycle and is a trimeric complex consisting of Cyclin Dependent Kinase 7 (CDK7), Cyclin H and the accessory protein, MAT1. CDK7 also plays a ...
  • The pioneer factor PBX1 is a novel driver of metastatic progression in ERalpha-positive breast cancer 
    Magnani L; Patten DK; Nguyen VT; Hong SP; Steel JH; Patel N; Lombardo Y; Faronato M; Gomes AR; Woodley L; Page K; Guttery D; Primrose L; Fernandez Garcia D; Shaw J; Viola P; Green A; Nolan N; Ellis IO; Rakha EA; Shousha S; Lam EW; Győrffy, Balázs; Lupien M; Coombes RC (2015)
    Over 30% of ERalpha breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ...