Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and ...
Ambrus, Attila; Wang Junjie; Mizsei, Réka; Zámbó, Zsófia; Törőcsik, Beáta; Jordan Frank; Ádám-Vizi, Veronika(2016)
Pathogenic amino acid substitutions of the common E3 component (hE3) of the human alpha-ketoglutarate dehydrogenase and the pyruvate dehydrogenase complexes lead to severe metabolic diseases (E3 deficiency), which usually ...