MTMT-ben szereplő publikációk tallózása szerző szerint "Patten DK"

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  • Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion 
    Nguyen VTM; Barozzi I; Faronato M; Lombardo Y; Steel JH; Patel N; Darbre P; Castellano L; Győrffy B; Woodley L; Meira A; Patten DK; Vircillo V; Periyasamy M; Ali S; Frige G; Minucci S; Coombes RC; Magnani L (2015)
    Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we ...
  • Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer 
    Patten DK; Corleone G; Győrffy, Balázs; Perone Y; Slaven N; Barozzi I; Erdős, Edina; Saiakhova A; Goddard K; Vingiani A; Shousha S; Pongor, Lőrinc; Hadjiminas DJ; Schiavon G; Barry P; Palmieri C; Coombes RC; Scacheri P; Pruneri G; Magnani L (2018)
    The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific ...
  • The pioneer factor PBX1 is a novel driver of metastatic progression in ERalpha-positive breast cancer 
    Magnani L; Patten DK; Nguyen VT; Hong SP; Steel JH; Patel N; Lombardo Y; Faronato M; Gomes AR; Woodley L; Page K; Guttery D; Primrose L; Fernandez Garcia D; Shaw J; Viola P; Green A; Nolan N; Ellis IO; Rakha EA; Shousha S; Lam EW; Győrffy, Balázs; Lupien M; Coombes RC (2015)
    Over 30% of ERalpha breast cancer patients develop relapses and progress to metastatic disease despite treatment with endocrine therapies. The pioneer factor PBX1 translates epigenetic cues and mediates estrogen induced ...