Folyóiratcikkek tallózása szerző szerint "Klekner, Álmos"

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  • Cytogenetic Prognostication Within Medulloblastoma Subgroups 
    Shih, DJ; Northcott, PA; Remke, M; Korshunov, A; Ramaswamy, V; Kool, M; Luu, B; Yao, Y; Wang, X; Dubuc, AM; Garzia, L; Peacock, J; Mack, SC; Wu, X; Rolider, A; Morrissy, AS; Cavalli, FM; Jones, DT; Zitterbart, K; Faria, CC; Schuller, U; Kren, L; Kumabe, T; Tominaga, T; Shin, Ra Y; Garami, Miklós; Hauser, Péter; Chan, JA; Robinson, S; Bognár, László; Klekner, Álmos; Saad, AG; Liau, LM; Albrecht, S; Fontebasso, A; Cinalli, G; De Antonellis, P; Zollo, M; Cooper, MK; Thompson, RC; Bailey, S; Lindsey, JC; Di Rocco, C; Massimi, L; Michiels, EM; Scherer, SW; Phillips, JJ; Gupta, N; Fan, X; Muraszko, KM; Vibhakar, R; Eberhart, CG; Fouladi, M; Lach, B; Jung, S; Wechsler-Reya, RJ; Fevre-Montange, M; Jouvet, A; Jabado, N; Pollack, IF; Weiss, WA; Lee, JY; Cho, BK; Kim, SK; Wang, KC; Leonard, JR; Rubin, JB; de Torres, C; Lavarino, C; Mora, J; Cho, YJD; Tabori, U; Olson, JM; Gajjar, A; Packer, RJ; Rutkowski, S; Pomeroy, SL; French, PJ; Kloosterhof, NK; Kros, JM; Van, Meir EG; Clifford, SC; Bourdeaut, F; Delattre, O; Doz, FF; Hawkins, CE; Malkin, D; Grajkowska, WA; Perek-Polnik, M; Bouffet, E; Rutka, JT; Pfister, SM; Taylor, M (2014)
    PURPOSE: Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent ...
  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma 
    Schwartzentruber, J; Korshunov, A; Liu, XY; Jones, DT; Pfaff, E; Jacob, K; Sturm, D; Fontebasso, AM; Quang, DA; Tonjes, M; Hovestadt, V; Albrecht, S; Kool, M; Nantel, A; Konermann, C; Lindroth, A; Jager, N; Rausch, T; Ryzhova, M; Korbel, JO; Hielscher, T; Hauser, Péter; Garami, Miklós; Klekner, Álmos; Bognár, László; Ebinger, M; Schuhmann, MU; Scheurlen, W; Pekrun, A;; Fruhwald, MC; Roggendorf, W; Kramm, C; Durken, M; Atkinson, J; Lepage, P; Montpetit, A; Zakrzewska, M; Zakrzewski, K; Liberski, PP; Dong, Z; Siegel, P; Kulozik, AE; Zapatka, M; Guha, A; Malkin, D; Felsberg, J; Reifenberger, G; von Deimling, A; Ichimura, K; Collins, VP; Witt, H; Milde, T; Witt, O; Zhang, C; Castelo-Branco, P; Lichter, P; Faury, D; Tabori, U; Plass, C; Majewski, J; Pfister, SM; Jabado, N (2012)
    Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events ...
  • Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR 
    Kleinman, CL; Gerges, N; Papillon-Cavanagh, S; Sin-Chan, P; Pramatarova, A; Quang, DA; Adoue, V; Busche, S; Caron, M; Djambazian, H; Bemmo, A; Fontebasso, AM; Spence, T; Schwartzentruber, J; Albrecht, S; Hauser, Péter; Garami, Miklós; Klekner, Álmos; Bognár, László; Montes, JL; Staffa, A; Montpetit, A; Berube, P; Zakrzewska, M; Zakrzewski, K; Liberski, PP; Dong, Z; Siegel, PM; Duchaine, T; Perotti, C; Fleming, A; Faury, D; Remke, M; Gallo, M; Dirks, P; Taylor, MD; Sladek, R; Pastinen, T; Chan, JA; Huang, A; Majewski, J; Jabado, N (2014)
    Embryonal tumors with multilayered rosettes (ETMRs) are rare, deadly pediatric brain tumors characterized by high-level amplification of the microRNA cluster C19MC. We performed integrated genetic and epigenetic analyses ...
  • Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma 
    Sturm, Dominik; Witt, Hendrik; Hovestadt, Volker; Khuong-Quang, Dong-Anh; Jones, David TW; Carolin, Konermann; Elke, Pfaff; Martje, Tönjes; Martin, Sill; Sebastian, Bender; Marcel, Kool; Marc, Zapatka; Natalia, Becker; Manuela, Zucknick; Thomas, Hielscher; Xiao-Yang, Liu; Adam, M Fontebasso; Marina, Ryzhova; Steffen, Albrecht; Karine, Jacob; Marietta, Wolter; Martin, Ebinger; Martin, U Schuhmann; Timothy, van Meter; Michael, C Frühwald; Holger, Hauch; Arnulf, Pekrun; Bernhard, Radlwimmer; Tim, Niehues; Gregor, von Komorowski; Matthias, Dürken; Andreas, E Kulozik; Jenny, Madden; Andrew, Donson; Nicholas, K Foreman; Rachid, Drissi; Maryam, Fouladi; Wolfram, Scheurlen; Andreas, von Deimling; Camelia, Monoranu; Wolfgang, Roggendorf; Christel, Herold-Mende; Andreas, Unterberg; Christof, M Kramm; Jörg, Felsberg; Christian, Hartmann; Benedikt, Wiestler; Wolfgang, Wick; Till, Milde; Olaf, Witt; Anders, M Lindroth; Jeremy, Schwartzentruber; Damien, Faury; Adam, Fleming; Magdalena, Zakrzewska; Pawel, P Liberski; Krzysztof, Zakrzewski; Hauser, Péter; Garami, Miklós; Klekner, Álmos; Bognár, László; Sorana, Morrissy; Florence, Cavalli; Michael, D Taylor; Peter, van Sluis; Jan, Koste; Rogier, Versteeg; Richard, Volckmann; Tom, Mikkelsen; Kenneth, Aldape; Guido, Reifenberger; V Peter, Collins; Jacek, Majewski; Andrey, Korshunov; Peter, Lichter; Christoph, Plass; Nada, Jabado; Stefan, M Pfister; (2012)
    Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone ...
  • Intertumoral Heterogeneity within Medulloblastoma Subgroups 
    Cavalli, FMG; Remke, M; Rampasek, L; Peacock, J; Shih, DJH; Luu, B; Garzia, L; Torchia, J; Nor, C; Morrissy, AS; Agnihotri, S; Thompson, YY; Kuzan-Fischer, CM; Farooq, H; Isaev, K; Daniels, C; Cho, BK; Kim, SK; Wang, KC; Lee, JY; Grajkowska, WA; Perek-Polnik, M; Vasiljevic, A; Faure-Conter, C; Jouvet, A; Giannini, C; Rao, AAN; Li, KKW; Ng, HK; Eberhart, CG; Pollack, IF; Hamilton, RL; Gillespie, GY; Olson, JM; Leary, S; Weiss, WA; Lach, B; Chambless, LB; Thompson, RC; Cooper, MK; Vibhakar, R; Hauser, Péter; van Veelen, MLC; Kros, JM; French, PJ; Ra, YS; Kumabe, T; Lopez-Aguilar, E; Zitterbart, K; Sterba, J; Finocchiaro, G; Massimino, M; Van, Meir EG; Osuka, S; Shofuda, T; Klekner, Álmos; Zollo, M; Leonard, JR; Rubin, JB; Jabado, N; Albrecht, S; Mora, J; Van, Meter TE; Jung, S; Moore, AS; Hallahan, AR; Chan, JA; Tirapelli, DPC; Carlotti, CG; Fouladi, M; Pimentel, J; Faria, CC; Saad, AG; Massimi, L; Liau, LM; Wheeler, H; Nakamura, H; Elbabaa, SK; Perezpeña-Diazconti, M; Chico Ponce de León, F; Robinson, S; Zapotocky, M; Lassaletta, A; Huang, A; Hawkins, CE; Tabori, U; Bouffet, E; Bartels, U; Dirks, PB; Rutka, JT; Bader, GD; Reimand, J; Goldenberg, A; Ramaswamy, V; Taylor, MD (2017)
    While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene ...
  • Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis 
    Torchia J; Picard D; Lafay-Cousin L; Hawkins C E; Kim S -K; Letourneau; Ra Y -S; Ho K C; Chan T S Y; Sin-Chan P; Dunham C; Yip S; Ng H -K; Lu J -Q; Albrecht S; Pimentel J; Chan J A; Somers G R; Zielenska M; Faria C C; Roque L; Baskin B; Birks D; Foreman N; Strother D; Klekner, Álmos; Garami, Miklós; Hauser, Péter; Hortobágyi, Tibor; Bognár L; Wilson B; Hukin J; Carret A -S; Van Meter T E; Nakamura H; Toledano H; Fried I; Fults D; Wataya T; Fryer C; Eisenstat D D; Scheineman K; Johnston D; Michaud J; Zelcer S; Hammond R; Ramsay D A; Fleming A J; Lulla R R; Fangusaro J R; Sirachainan N; Larbcharoensub N; Hongeng S; Barakzai M A; Montpetit A; Stephens D; Grundy R G; Schüller U; Nicolaides T; Tihan T; Phillips J; Taylor M D; Rutka J T; Dirks P; Bader G D; Warmuth-Metz M; Rutkowski S; Pietsch T; Judkins A R; Jabado N; Bouffet E; Huang A (2015)
    BACKGROUND: Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of biological understanding of the substantial ...
  • Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas 
    Fontebasso AM; Schwartzentruber J; Khuong-Quang D-A; Liu X-Y; Sturm D; Korshunov A; Jones DTW; Witt H; Kool M; Albrecht S; Fleming A; Hadjadj D; Busche S; Lepage P; Montpetit A; Staffa A; Gerges N; Zakrzewska M; Zakrzewski K; Liberski PP; Hauser, Péter; Garami, Miklós; Klekner, Álmos; Bognár, László; Zadeh G; Faury D; Pfister SM; Jabado N; Majewski J (2013)
    Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To identify additional driver mutations in HGGs, we investigated ...
  • Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age 
    Fontebasso AM; Shirinian M; Khuong-Quang DA; Bechet D; Gayden T; Kool M; De Jay N; Jacob K; Gerges N; Hutter B; Seker-Cin H; Witt H; Montpetit A; Brunet S; Lepage P; Bourret G; Klekner, Álmos; Bognar L; Hauser, Péter; Garami, Miklós; Farmer JP; Montes JL; Atkinson J; Lambert S; Kwan T; Korshunov A; Tabori U; Collins VP; Albrecht S; Faury D; Pfister SM; Paulus W; Hasselblatt M; Jones DT; Jabado N (2015)
    Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid ...
  • Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma 
    Al-Halabi H; Nantel A; Klekner, Álmos; Guiot MC; Albrecht S; Hauser, Péter; Garami, Miklós; Bognár, László; Kavan P; Gerges N; Shirinian M; Roberge D; Muanza T; Jabado N (2011)
  • Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis 
    Thompson, EM; Hielscher, T; Bouffet, E; Remke, M; Luu, B; Gururangan, S; McLendon, RE; Bigner, DD; Lipp, ES; Perreault, S; Cho, YJ; Grant, G; Kim, SK; Lee, JY; Rao, AA; Giannini, C; Li, KK; Ng, HK; Yao, Y; Kumabe, T; Tominaga, T; Grajkowska, WA; Perek-Polnik, M; Low, DC; Seow, WT; Chang, KT; Mora, J; Pollack, IF; Hamilton, RL; Leary, S; Moore, AS; Ingram, WJ; Hallahan, AR; Jouvet, A; Fevre-Montange, M; Vasiljevic, A; Faure-Conter, C;; Shofuda, T; Kagawa, N; Hashimoto, N; Jabado, N; Weil, AG; Gayden, T; Wataya, T; Shalaby, T; Grotzer, M; Zitterbart, K; Sterba, J; Kren, L; Hortobágyi, Tibor; Klekner, Álmos; Laszlo, B; Pócza, Tímea; Hauser, Péter; Schuller, U; Jung, S; Jang, WY; French, PJ; Kros, JM; van Veelen, MC; Massimi, L; Leonard, JR; Rubin, JB; Vibhakar, R; Chambless, LB; Cooper, MK; Thompson, RC; Faria, CC; Carvalho, A; Nunes, S; Pimentel, J; Fan, X; Muraszko, KM; Lopez-Aguilar, E; Lyden, D; Garzia, L; Shih, DJ; Kijima, N; Schneider, C; Adamski, J; Northcott, PA; Kool, M; Jones, DT; Chan, JA; Nikolic, A; Garre, ML; Van, Meir EG; Osuka, S; Olson, JJ; Jahangiri, A; Castro, BA; Gupta, N; Weiss, WA; Moxon-Emre, I; Mabbott, DJ; Lassaletta, A; Hawkins, CE; Tabori, U; Drake, J; Kulkarni, A; Dirks, P; Rutka, JT; Korshunov, A; Pfister, SM; Packer, RJ; Ramaswamy, V; Taylor, MD (2016)
    BACKGROUND: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called ...
  • Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. 
    Fontebasso AM; Papillon-Cavanagh S; Schwartzentruber J; Nikbakht H; Gerges N; Fiset PO; Bechet D; Faury D; De Jay N; Ramkissoon LA; Corcoran A; Jones DT; Sturm D; Johann P; Tomita T; Goldman S; Nagib M; Bendel A; Goumnerova L; Bowers DC; Leonard JR; Rubin JB; Alden T; Browd S; Geyer JR; Leary S; Jallo G; Cohen K; Gupta N; Prados MD; Carret AS; Ellezam B; Crevier L; Klekner, Álmos; Bognár, László; Hauser, Péter; Garami, Miklós; Myseros J; Dong Z; Siegel PM; Malkin H; Ligon AH; Albrecht S; Pfister SM; Ligon KL; Majewski J; Jabado N; Kieran MW (2014)
    Pediatric midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets identified. Most tumors harbor mutations encoding p.Lys27Met in histone H3 variants. In 40 treatment-naive mHGAs, 39 analyzed by ...
  • Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma 
    Zhukova N; Ramaswamy V; Remke M; Pfaff E; Shih DJ; Martin, DC; Castelo-Branco, P; Baskin, B; Ray, PN; Bouffet, E; von Bueren, AO; Jones, DT; Northcott, PA; Kool, M; Sturm, D; Pugh, TJ; Pomeroy, SL; Cho, YJ; Pietsch, T; Gessi, M; Rutkowski, S; Bognár, László; Klekner, Álmos; Cho, BK; Kim, SK; Wang, KC; Eberhart, CG; Fevre-Montange, M; Fouladi, M; French, PJ; Kros, M; Grajkowska, WA; Gupta, N; Weiss, WA; Hauser, Péter; Jabado, N; Jouvet, A; Jung, S; Kumabe, T; Lach, B; Leonard, JR; Rubin, JB; Liau, LM; Massimi, L; Pollack, IF; Shin, Ra Y; Van, Meir EG; Zitterbart, K; Schuller, U; Hill, RM; Lindsey, JC; Schwalbe, EC; Bailey, S; Ellison, DW; Hawkins, C; Malkin, D; Clifford, SC; Korshunov, A; Pfister, S; Taylor, MD; Tabori, U (2013)
    PURPOSE Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. PATIENTS AND METHODS We ...
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes 
    Northcott, PA; Shih, DJH; Peacock, J; Garzia, L; Sorana Morrissy, A; Zichner, T; Stütz, AM; Korshunov, A; Reimand, J; Schumacher, SE; Beroukhim, R; Ellison, DW; Marshall, CR; Lionel, AC; Mack, S; Dubuc, A; Yao, Y; Ramaswamy, V; Luu, B; Rolider, A; Cavalli, FMG; Wang, X; Remke, M; Wu, X; Chiu, RYB; Chu, A; Chuah, E; Corbett, RD; Hoad, GR; Jackman, SD; Li, Y; Lo, A; Mungall, KL; Ming, Nip K; Qian, JQ; Raymond, AGJ; Thiessen, N; Varhol, RJ; Birol, I; Moore, RA; Mungall, AJ; Holt, R; Kawauchi, D; Roussel, MF; Kool, M; Jones, DTW; Witt, H; Fernandez-L A; Kenney, AM; Wechsler-Reya, RJ; Dirks, P; Aviv, T; Grajkowska, WA; Perek-Polnik, M; Haberler, CC; Delattre, O; Reynaud, SS; Doz, FF; Pernet-Fattet, SS; Cho, B-K; Kim, S-K; Wang, K-C; Scheurlen, W; Eberhart, CG; Fèvre-Montange, M; Jouvet, A; Pollack, IF; Fan, X; Muraszko, KM; Yancey, Gillespie G; Di Rocco, C; Massimi, L; Michiels, EMC; Kloosterhof, NK; French, PJ; Kros, JM; Olson, JM; Ellenbogen, RG; Zitterbart, K; Kren, L; Thompson, RC; Cooper, MK; Lach, B; McLendon, RE; Bigner, DD; Fontebasso, A; Albrecht, S; Jabado, N; Lindsey, JC; Bailey, S; Gupta, N; Weiss, WA; Bognár, László; Klekner, Álmos; Van, Meter TE; Kumabe, T; Tominaga, T; Elbabaa, SK; Leonard, JR; Rubin, JB; Liau, LM; Van, Meir EG; Fouladi, M; Nakamura, H; Cinalli, G; Garami, Miklós; Hauser, Péter; Saad, AG; Iolascon, A; Jung, S; Carlotti, CG; Vibhakar, R; Shin, Ra Y; Robinson, S; Zollo, M; Faria, CC; Chan, JAD; Levy, ML; Sorensen, PHB; Meyerson, M; Pomeroy, SL; Cho, Y-J; Bader, GD; Tabori, U; Hawkins, CE; Bouffet, E; Scherer, SW; Rutka, JT; Malkin, D; Clifford, SC; Jones, SJM; Korbel, JO; Pfister, SM; Marra, MA; Taylor, MD (2012)
    Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits ...
  • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. 
    Remke M,; Ramaswamy V,; Peacock J,; Shih DJ,; Koelsche C,; Bognár, László; Klekner, Álmos; Garami, Miklós; Hauser, Péter (2013)
    Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT ...