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T*
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T*
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T*
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T*
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T*
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()Tj
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T*
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[(differences)-241.2(in)-232.7(the)-235(LVDP,)-241(the)-235(LV)-234.7(dp/dt)-230.4(max,)-239.5(or)-232.6(LV)-234.7(dp/dt)-236.2(min)]TJ
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T*
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()Tj
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[(tution.)-361.8(The)-357(two)-361.4(therapy)-361.5(options,)-356.8(captopril)-363.9(and)-355.8(tempol,)-364(sig-)]TJ
T*
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[(disulphide)-340.7(cross-bridges)-338.6(\(DCB\))-342.4(at)-337.6(the)-332.9(level)-342.2(of)-336.2(cystein)-338.4(resi-)]TJ
T*
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0 -1.1174 TD
[(be)-504.5(detected)-503.3(as)-498.5(high-molecular-weight)-508.5(peptide)-505.6(\()]TJ
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20.1244 0 TD
(*)Tj
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1.0022 0 TD
[(80)-169.2(kDa\))]TJ
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[(under)-219.7(non-reducin)-8.8(g)-214.2(conditions)-219.7(in)-221.2(immunoelectrophoresis.)-223.8(L-)]TJ
T*
[(NAME)-423(application)-419.3(did)-418.1(not)-418.1(have)-415.7(any)-419.2(effects)-420(on)-416.9(DCB)-420.9(for-)]TJ
T*
[(mation)-268.4(in)-261.5(the)-258(LV;)-264.7(however,)-267.7(in)-261.5(the)-258(RV,)-266.7(a)-261.4(signicant)-261(increase)]TJ
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[(in)-733.8(cross-linking)-729.6(processes)-732.8(was)-730.9(detected,)-737.1(leading)-730.3(to)-728.1(a)]TJ
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()Tj
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[(DHE)-420.9(staining,)-416.8(a)-417(specic)-425.7(powerful)-414.1(oxidant)-418.1(species,)-423.3(perox-)]TJ
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[(ynitri)-7(te)-256.9(\(ONOO)]TJ
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7.3823 0 0 6.5614 376.044 378.8219 Tm
(-)Tj
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9.843 0 0 9.843 380.3527 374.4566 Tm
[(\),)-263.7(was)-258.6(quantied)-260(in)-261.5(the)-258(tissues)-262(from)-259(the)-258(RV)]TJ
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[(and)-321.2(LV.)-313(The)-316.7(formation)-317.8(of)-319(ONOO)]TJ
/F6 1 Tf
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(-)Tj
/F5 1 Tf
9.843 0 0 9.843 456.9448 363.5149 Tm
[(is)-313.2(based)-318.7(on)-313.2(the)-315.6(reaction)]TJ
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[(free)-519.3(radical)-518.3(properties,)-523.6(but)-516(it)-515.1(can)-518.2(dissociate)-515.6(rapidly)-521.7(into)]TJ
T*
[(highly)-283.3(reactive)-284.4(decomposition)-283(products.)]TJ
1.0137 -1.1116 TD
[(Comparable)-253(to)-244.2(the)-240.7(results)-250.6(obtained)-247.6(for)-245.1(radical)-247.6(staining,)-244(no)]TJ
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[(group)-270.4(difference)-274.9(could)-271.7(be)-268.3(detected)-278.7(for)-268.2(the)-269.5(LV)-269.2(concentration)]TJ
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(-)Tj
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(ONOO)Tj
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(-)Tj
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[(NAME)-411.4(substitution)-405.1(led)-407.8(to)-405.5(a)-405.4(further)-406.3(signicant)-405(increase)-410.8(in)]TJ
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T*
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(-)Tj
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[(concentration)-566.5(in)-561(the)-563.3(RV)]TJ
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1.0137 -1.1116 TD
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11.5828 0 TD
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[(p)-5.3(l).3(as)-5.1(ma)-185(was)-183.7(d).4(e)-6.5(t).3(er)-5.3(mine)-6.5(d)-178.1(a)-6.5(s)-183.7(a)-179.3(g)-5.3(e)-.7(ner)-5.3(a)-.7(l)-184(i).3(nd)-5.3(ica)-6.5(t).3(or)-183.8(of)-183.8(o)-5.3(x).4(ida)-6.5(tiv)-5.3(e)-179.3(s)-5.1(tr)-5.3(ess)-5.1(.)]TJ
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0 Tc
()Tj
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[(.L)283.3(,)]TJ
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0 Tc
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(<)Tj
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T*
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(2)Tj
9.843 0 0 9.843 450.1983 133.3417 Tm
(O)Tj
7.3823 0 0 6.5614 457.2849 131.6976 Tm
(2)Tj
9.843 0 0 9.843 460.97 133.3417 Tm
[(\))-358.2(and)-355.8(oxygen)-359.1(and)-355.8(thus)]TJ
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[(perform)-568.7(important)-565.6(antioxidant)-562.1(functions.)-567.5(The)-564.4(expression)]TJ
T*
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0 -1.1174 TD
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0 -1.1116 TD
[(groups.)-407.2(Only)-408.6(the)-407.8(expression)-410.5(of)-405.3(SOD2)-409.2(was)-408.3(specically)-408.5(in-)]TJ
T*
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0 -1.1174 TD
(51%)Tj
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()Tj
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[(RV)-188.4(by)-186.5(30%)]TJ
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4.7575 0 TD
()Tj
/F5 1 Tf
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[(4%.)-185.3(No)-187.4(signicant)-186.2(changes)-189.6(could)-185.3(be)-187.7(detected)-186.5(in)]TJ
ET
q
1 i
62.759 732.245 m
300.416 732.245 l
300.416 401.669 l
62.759 401.669 l
W n
q
237.657 0 0 330.576 62.759 401.669 cm
/Im2 Do
Q
Q
BT
/F8 1 Tf
9.845 0 0 9.845 62.022 384.8881 Tm
[(FIG.)-423.1(1.)-1000.6(L-)20.1(NA)19.4(ME)-339.1(in)21(du)21.4(ce)18.7(d)-346.3(c)0(h)20.1(a)0(n)21.2(g)0(e)19.9(s)-346.3(in)-341.7(c)15.1(a)0(r)19.9(d)0(i)21.1(a)0(c)-342.9(r)15.1(em)18.9(od)21.2(el)19.7(-)]TJ
0 -1.0135 TD
[(in)21(g.)-528.4(\(A\))]TJ
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4.0252 0 TD
[(Effects)-557.5(of)-549(the)-551.4(different)-552.9(treatment)-555.4(strategies)-554.9(on)]TJ
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[(myocardial)-395(hypertrophy.)-395.7(The)-396.9(wet)-391(weight)-394.1(of)-393.6(the)-395.9(right)-391.1(ven-)]TJ
0 -1.0135 TD
[(tricle)-377.4(\(RV\))-374.3(and)-378.4(left)-374(ventricle)-381.5(\(LV\))-374.5(were)-375.7(normalized)-377.7(to)-376.5(the)]TJ
T*
[(body)-654.7(weight)-659(\(BW\))-657.8(of)-658.5(the)-655(particular)-658.9(animal.)-658.1(Data)-658(are)]TJ
T*
(means)Tj
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2.7295 0 TD
()Tj
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[(S.D.)-389.4(of)]TJ
/F7 1 Tf
3.3803 0 TD
(n)Tj
/F6 1 Tf
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(=)Tj
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[(8)-386.8(hearts.)]TJ
/F8 1 Tf
3.9216 0 TD
(\(B\))Tj
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1.7218 0 TD
[(Representative)-395.4(images)-395.3(of)]TJ
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[(horizontal)-467.7(heart)-462.4(sections)-465.2(from)-465.8(each)-462.4(treatment)-463.3(group.)-463.2(The)]TJ
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