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[(od)20.8(s)-358(a)0(n)19.7(d)-358.2(ai)25.3(ms)-348.8(of)-347.7(th)20.7(e)-359.4(m)15(ea)18.5(su)26.8(re)19.7(m)15(e)0(n)19.7(t)0(s)-347.7(a)0(n)25.4(d)-358.2(si)20.9(gn)20.8(e)15(d)-358.2(th)20.7(e)-359.4(i)0(n)20.7(f)16.2(or)20.9(m)15(e)0(d)]TJ
0 -1.1116 TD
[(co)19.7(ns)21(e)15(n)0(t)-371(f)0(o)26.6(r)0(m)19.6(.)-377.8(Th)19.6(e)-382.4(s)0(t)26.7(u)0(d)20.8(y)-381.2(w)15.3(a)0(s)-371.8(a)0(p)19.7(p)16.2(ro)20.9(ve)25.4(d)-381.2(b)0(y)-370.8(t)0(h)20.7(e)-376.6(Et)19.5(hi)26.5(cs)-371.8(Co)19.8(m)15(-)]TJ
T*
[(mi)19.5(tt)26.3(ee)-240.7(of)-238.3(t)16(h)0(e)-239.5(S)0(e)25.6(m)0(m)18.4(e)15(lw)19.8(e)15(i)0(s)-238.3(U)0(n)20(i)16.1(ve)19.7(rs)21.1(i)16(t)0(y)-238.5(\()0(T)25.4(U)0(K)19.1(E)15(B)-249.8(2)0(3)20.8(9)0(/)26.5(2)0(0)20.8(1)16.2(5\))20.9(.)]TJ
/F11 1 Tf
8.9663 0 0 8.9663 313.0582 591.7605 Tm
[(Study)-338.6(design)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 575.3195 Tm
[(Th)19.6(e)-273(s)0(u)26.8(b)0(j)20.7(e)0(c)24.3(t)0(s)-261.3(a)0(t)19.5(t)0(e)25.3(n)0(d)20.8(e)0(d)-262.6(a)-273(si)20.9(n)16.2(g)0(l)20.7(e)-273(vi)20.7(si)26.7(t.)-263.8(Al)25.6(l)-277.7(p)0(a)25.4(t)0(i)20.6(e)15(nt)20.7(s)-271.6(p)0(e)19.7(r)0(f)26.7(o)0(r)20.9(m)15(ed)]TJ
-1.0137 -1.1116 TD
[(st)20.9(an)19.7(d)16.2(a)0(r)19.7(d)-323.6(lu)20.7(n)16.2(g)-329.4(f)16.2(u)0(n)20.8(c)0(t)25.3(i)0(o)20.7(n)-323.6(te)25.3(st)20.9(s,)-315.4(wh)25.7(ic)19.5(h)-323.6(w)0(e)24.6(r)0(e)-314.4(f)0(o)20.9(l)0(l)26.3(o)0(w)20(e)0(d)-314.4(b)0(y)-313.2(t)0(h)26.5(e)-330.6(i)16(n)0(-)]TJ
T*
[(ha)19.7(la)25.3(ti)20.6(on)-244.1(m)15(a)0(n)19.7(e)15(uv)20.8(er)25.5(s)-260.1(u)16.2(si)20.9(ng)-244.1(a)15(t)-260.4(l)16.1(e)0(a)18.5(s)0(t)-244(t)16.1(hr)20.9(ee)-246.4(d)16.2(i)0(f)20.7(f)0(e)25.5(r)0(e)19.7(n)0(t)-244.2(i)0(n)26.5(h)0(a)19.7(l)0(e)25.3(r)0(s)-243.9(a)0(f)19.7(t)16.1(er)]TJ
T*
[(a)-290.2(m)15(in)20.7(i)16(m)0(u)19.6(m)-284.5(of)-272.9(a)-284.5(3)0(0)26.6(-)0(m)19.6(i)0(n)26.5(u)0(t)20.7(e)-284.5(br)20.9(e)15(a)0(k)19.7(.)-279.9(Su)21(bj)26.5(ec)18.5(ts)-272.8(l)26.6(le)19.5(d)-283.3(o)0(u)20.8(t)-283.5(di)26.5(se)19.9(as)25.6(e-)]TJ
0 -1.1174 TD
[(sp)21(ec)24.3(i)20.9(c)-324.8(a)15(nd)-313.2(g)16.2(e)0(n)19.7(e)15(ri)20.7(c)-324.8(q)16.2(ua)19.7(l)16.1(i)0(t)20.6(y)0(-)20.9(o)16.2(f-)20.9(li)26.3(fe)-314.4(q)16.2(u)0(e)19.7(s)0(t)26.7(i)0(o)20.7(n)0(n)26.6(a)0(i)19.5(r)0(e)25.5(s)0(.)]TJ
/F11 1 Tf
8.9663 0 0 8.9663 313.0582 507.7416 Tm
[(Lung)-333.8(function)-337.4(measurements)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 491.3007 Tm
[(Using)-409.5(an)-406.5(electronic)-413.4(spirometer)-412(and)-407.6(body)-407.6(plethysmogra-)]TJ
-1.0137 -1.1116 TD
[(phy)-291.3(\(PDD-3)-8.1(01/s;)-287.8(Piston,)-292.2(Budapest,)-297.8(Hungary\),)-296.4(lung)-286.8(function)]TJ
0 -1.1174 TD
[(measureme)-11(nts)-412.2(were)-422.3(performed)-416.6(according)-422.4(to)-417(the)-419.3(American)]TJ
0 -1.1116 TD
[(Thora)-7.8(cic)-362.9(Society)-361.5(and)-361.6(European)-363.6(Respiratory)-366.8(Society)-361.5(guide-)]TJ
T*
(lines.)Tj
7.3823 0 0 6.5614 334.2046 451.8424 Tm
(\(18\))Tj
9.843 0 0 9.843 351.0991 447.4771 Tm
[(Pulmonary)-473(function)-465.2(variables)-474.2(were)-468.3(expressed)-468(as)]TJ
-3.8648 -1.1116 TD
[(the)-292.6(percentage)-293.4(of)-290.2(predicted)-290.1(values.)-288.8(None)-294.4(of)-284.4(the)-292.6(records)-286.3(was)]TJ
0 -1.1174 TD
[(post-broncho)-8.5(dilator)-331.8(measurements.)]TJ
/F11 1 Tf
8.9663 0 0 8.9663 313.0582 401.7826 Tm
[(Inhalation)-337.4(maneuvers)-334.7(through)-331.2(different)-337.2(inhalers)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 385.3416 Tm
-.0158 Tc
[(Fo)-15.8(u)10.8(r)-183.9(com)-15.8(m)8.3(ercia)-15.8(l)9.5(ly)-183.9(av)-15.8(a)9.6(ilab)-15.8(l)10.7(e)-185.1(i).3(nh)-15.8(a)9.6(l).2(ers)-189.5(w)-.5(ere)-185.1(u)-15.8(s)11(e)-.8(d)-183.9(i).3(n)-183.9(o)-15.8(u)10.8(r)-183.9(stu)-15.8(d)10.8(y:)]TJ
-1.0137 -1.1116 TD
0 Tc
[(tw)25.6(o)-185.4(D)15.3(P)16.3(I)0(s)-174.8(\()16.2(E)15(l)0(l)26.3(i)16(p)16.2(t)0(a)]TJ
/F8 1 Tf
7.3823 0 0 6.5614 378.9353 378.7653 Tm
()Tj
/F5 1 Tf
9.843 0 0 9.843 386.5889 374.3999 Tm
-.0156 Tc
[(an)-15.6(d)-190.6(G)-.3(enu)-15.6(a)9.8(ir)]TJ
/F8 1 Tf
7.3823 0 0 6.5614 433.1337 378.7653 Tm
0 Tc
()Tj
/F5 1 Tf
9.843 0 0 9.843 438.8597 374.3999 Tm
-.016 Tc
[(\),)-203.7(one)-202.6(p)-16(M)9.7(DI)-201.4(\(E)-16(v)9.4(ohal)-16(e)9.3(r)]TJ
/F8 1 Tf
7.3823 0 0 6.5614 525.0896 378.7653 Tm
0 Tc
()Tj
/F5 1 Tf
9.843 0 0 9.843 530.8156 374.3999 Tm
-.0159 Tc
[(\),)-203.6(and)]TJ
-22.123 -1.1174 TD
0 Tc
[(on)26.6(e)-186.6(S)16.3(MI)-175.9(\()16.2(R)15.2(es)25.6(p)16.2(i)16.1(ma)24.2(t)]TJ
/F8 1 Tf
7.3823 0 0 6.5614 387.1558 367.7668 Tm
()Tj
/F5 1 Tf
9.843 0 0 9.843 392.8818 363.4015 Tm
-.0158 Tc
[(\).)-203.5(Inh)-15.8(a)9.6(l).2(ers)-206.8(w)-.5(it)-15.8(h)-190.9(acti)-15.8(v)10.7(e)-202.4(s)-15.8(u)11(b).4(st)-15.8(a)9.5(n).4(ces)-206.8(were)-208.1(not)]TJ
-8.1097 -1.1116 TD
0 Tc
[(ap)25.4(p)16.2(l)16.1(ie)25.3(d)-243(d)16.2(ur)26.6(i)16.1(n)16.2(g)-248.8(t)16.1(h)16.2(e)-244.2(st)26.7(u)16.2(d)16.2(y)0(.)]TJ
1.0137 -1.1116 TD
-.0204 Tc
[(F)-20.4(o).6(r)-568.6(t)-20.4(hr)-20.4(ou)-20.4(g)-5.3(h)-20.4(-d)-20.4(ev)-20.4(ic)-20.4(e)-554.8(l)-20.4(u)-5.4(n)-20.4(g)-552.5(f)-20.4(un)-20.4(c)-6.5(t)-20.4(io)-20.4(n)-552.5(t)-20.4(es)-20.4(t)-5.3(i)-20.4(ng)-20.4(,)-554.8(a)-20.4(n)-553.7(e)-20.4(l)-6.6(e)-20.4(ct)-20.4(ro)-20.4(ni)-20.4(c)]TJ
-1.0137 -1.1174 TD
0 Tc
[(sp)15.3(ir)20.7(om)19.6(et)19.6(er)-228(wa)18.8(s)-231.3(u)0(s)21(e)0(d)-228(\()0(P)21(D)0(D)19.1(-)0(3)15.1(0)0(1)20.8(/)0(s)20.9(h)0(;)-221.2(P)0(i)15.1(s)0(t)20.9(o)0(n)20.8(\))0(,)-223.4(w)0(h)20(i)0(c)13.8(h)-231.5(ha)19.7(s)-231.3(b)0(u)15.1(i)0(l)20.6(t)0(-)20.7(i)0(n)]TJ
0 -1.1116 TD
[(am)18.5(bi)14.9(en)19.7(t)-346.8(t)0(e)19.5(m)0(p)19.6(e)0(r)14(a)0(t)19.6(u)0(r)20.9(e)0(,)-339.8(p)0(r)20.9(e)0(s)14.1(s)0(u)21(r)0(e)19.7(,)-349(an)19.7(d)-352.4(h)0(u)20.8(m)0(i)19.5(d)0(i)20.7(t)0(y)-342.2(s)0(e)19.9(n)0(s)21(o)0(r)15.1(s)-346.5(fo)20.9(r)-352.4(t)0(h)20.7(e)]TJ
T*
[(fu)15.1(ll)20.6(y)-542.5(a)0(u)19.7(t)0(o)20.7(m)0(a)18.4(t)0(i)14.8(c)-543.7(BT)18.6(PS)-531.8(\(b)20.9(od)20.8(y)-548.3(t)0(e)19.5(m)0(p)19.6(e)0(r)19.7(a)0(t)19.5(u)0(r)20.9(e)0(,)-535.6(p)0(r)20.9(e)0(s)14.1(s)0(u)21(r)0(e)19.7(,)-544.8(wa)18.8(te)19.6(r)]TJ
T*
[(va)13.9(po)20.8(r)-381.2(s)0(a)14.1(t)0(u)20.7(r)0(a)19.7(t)0(e)19.5(d)0(\))-376.5(c)0(o)19.7(r)0(r)20.9(e)0(c)18.5(t)0(i)14.8(o)0(n)20.8(.)-383.6(It)-370.9(is)-376.5(eq)19.7(ui)20.7(pp)15.1(ed)-372(wi)19.8(th)-376.7(a)-382.4(P)0(i)15.1(n)0(k)20.8(F)0(l)20.9(o)0(w)]TJ
0 -1.1174 TD
[(o)15.2(wm)18.7(et)19.5(er)-377.7(\(P)21(PF)21.2(-1)20.9(8;)-376.7(Pi)15.1(st)20.9(on)20.8(\),)-378.9(wh)20(ic)19.5(h)-387(m)0(e)18.4(a)0(s)19.9(u)0(r)20.9(e)0(s)-377.5()0(o)21(w)-387.9(ba)19.7(se)19.9(d)-387(o)0(n)]TJ
0 -1.1116 TD
[(th)15(e)-388.2(p)0(r)20.9(i)0(n)15(c)0(i)19.5(p)0(l)20.7(e)-388.2(of)-382.3(a)-393.9(s)0(y)21(m)0(m)18.4(e)0(t)19.5(r)0(i)20.7(c)-393.9(an)19.7(d)-387(a)0(v)13.9(e)0(r)19.7(a)0(g)19.7(i)0(n)20.7(g)-392.7(Pi)20.9(to)20.7(t)-392.9(t)0(u)20.7(b)0(e)19.7(.)-389.3(Th)19.6(e)]TJ
T*
[(o)15.2(wm)18.7(et)19.5(er)-320.1(wa)13(s)-329.2(a)0(t)19.6(t)0(a)19.6(c)0(h)13.9(e)0(d)-320.1(t)0(o)-324.9(a)-330.6(pl)20.7(as)14.1(ti)20.6(c)-330.6(p)0(i)20.7(e)0(c)12.8(e)-330.6(co)19.7(nn)20.8(ec)18.5(ti)14.8(ng)-319(th)20.7(e)-336.3(i)0(n)20.7(-)]TJ
0 -1.1174 TD
[(ha)13.9(le)19.5(r)-536.7(u)0(n)15.1(d)0(e)19.7(r)-536.7(te)13.8(st)20.9(in)20.7(g)-542.5(\()0(F)21(i)0(g)20.7(.)-539.1(1\))20.9(.)-544.8(I)0(n)20.9(i)0(t)20.6(i)0(a)19.6(l)0(l)20.6(y)0(,)-534.4(e)0(i)19.5(g)0(h)20.8(t)-542.6(co)19.7(mm)18.4(er)19.7(ci)19.5(al)19.5(ly)]TJ
0 -1.1116 TD
[(av)13.9(ai)19.5(la)19.6(bl)20.7(e)-307.5(d)0(e)19.7(v)0(i)14.9(c)0(e)18.5(s)-306.2(we)18.8(re)-302.8(te)19.6(st)20.9(ed)-297.1(wi)14.1(th)-296.1(a)-307.5(3)0(-)20.9(L)-313.3(ca)18.5(li)20.6(br)20.9(at)19.5(io)20.7(n)-312.1(p)0(u)20.8(m)0(p)-297.2(a)0(t)]TJ
T*
[(30)15.1(-6)20.9(0-)20.9(90)-146.2(L/)19.5(mi)19.5(n)-381.2()0(o)21(w)-376.3(to)-370.9(in)20.7(ve)19.7(st)20.9(ig)14.9(at)19.5(e)-376.6(i)0(f)-370.9(o)0(u)20.8(r)-375.4(se)14.1(tu)20.7(p)-375.5(c)0(o)19.7(u)0(l)20.7(d)-381.2(ac)18.5(cu)19.7(-)]TJ
0 -1.1174 TD
[(ra)14(te)19.6(ly)-307.6(me)18.4(as)19.9(ur)20.9(e)-324.8(t)0(h)20.7(r)0(o)20.9(u)0(g)20.8(h)0(-)20.9(d)0(e)13.9(v)0(i)20.7(c)0(e)-309.8()0(o)21(w)-318.7(ra)19.7(te)19.6(.)-320.2(F)0(r)21(o)0(m)-308.7(t)0(h)15(e)-319(me)18.4(as)19.9(ur)20.9(ed)]TJ
0 -1.1116 TD
[(o)15.2(w)-278.4(r)0(a)19.7(t)0(e)19.6(,)-285.7(vo)20.8(lu)20.7(me)-269.5(wa)18.8(s)-283.1(c)0(a)18.5(l)0(c)19.5(u)0(l)20.7(a)0(t)13.8(e)0(d)19.7(.)-279.9(On)20(ly)-267.3(th)15(e)-278.7(f)0(o)20.9(u)0(r)-272.9(d)0(e)19.7(v)0(i)20.7(c)0(e)18.5(s)-283.1(us)21(ed)]TJ
T*
[(in)-457.3(ou)20.8(r)-461.8(s)0(t)15.1(u)0(d)20.8(y)-461.9(fu)20.9(l)20.9(ll)14.8(ed)-452.6(th)20.7(e)-463(c)0(r)19.7(i)0(t)14.8(e)0(r)19.7(i)0(a)-452.7(f)0(o)20.9(r)-467.6(re)19.7(li)20.6(ab)19.7(le)-452.7(o)15.2(w)-462.7(v)0(o)20.8(l)0(u)20.7(m)0(e)]TJ
0 -1.1174 TD
[(me)18.4(as)14.1(ur)20.9(em)18.5(en)19.7(t)-289.2(i)0(n)-273(o)0(u)15.1(r)-283.3(se)14.1(tu)20.7(p.)-275.2(Th)19.6(e)-290.2(c)0(o)19.7(n)0(n)20.8(e)0(c)18.5(t)0(i)14.8(n)0(g)-272.9(p)0(i)20.7(e)0(c)12.8(e)-284.5(wa)18.8(s)-288.9(u)0(s)21(e)0(d)-279.8(t)0(o)]TJ
0 -1.1116 TD
[(pr)15.1(ev)19.7(en)19.7(t)-519.6(a)0(n)-510.2(a)0(i)19.6(r)-519.4(le)13.8(ak)-510.2(an)19.7(d)-519.5(s)0(u)21(b)0(s)21(e)0(q)13.9(u)0(e)19.7(n)0(t)-509.2(c)0(h)19.7(a)0(n)19.7(g)0(e)19.7(s)-519.3(of)-514.8(me)18.4(as)19.9(ur)20.9(ed)]TJ
T*
[(pa)13.9(ra)19.7(me)18.4(te)19.6(rs)21.1(.)-458.4(T)0(h)19.6(e)-457.3(me)18.4(ta)19.6(l)-462(r)0(i)20.7(n)0(g)-445.7(w)0(i)19.8(t)0(h)-451.6(a)-457.3(ru)20.9(bb)20.8(er)-452.6(ov)20.8(er)19.7(la)19.6(y)-461.9(w)0(a)18.8(s)-455.9(at)19.5(-)]TJ
T*
[(ta)13.8(ch)19.7(ed)-239.5(to)-244.2(th)20.7(e)-255.7(d)0(i)20.7(f)0(f)20.9(e)0(r)14(e)0(n)19.7(t)-248.9(mo)19.6(ut)14.9(hp)20.8(ie)19.5(ce)18.5(s)-254.3(o)0(f)-244.1(t)0(h)20.7(e)-249.9(in)14.9(di)20.7(vi)20.7(du)20.8(al)-245.4(in)20.7(ha)19.7(le)19.6(rs)15.3(.)]TJ
0 -1.1174 TD
[(Al)14.1(l)-323.8(m)0(e)18.4(a)0(s)19.9(u)0(r)20.9(e)0(m)18.4(e)0(n)19.7(t)0(s)-313.2(w)0(e)18.8(r)0(e)-314.4(p)0(e)19.7(r)0(f)15.1(o)0(r)20.9(m)0(e)18.4(d)-323.6(th)20.7(ro)20.9(ug)20.8(h)-323.6(a)-324.8(ba)19.7(ct)13.8(er)19.7(ia)19.5(l)-323.8()0(l)20.9(t)0(e)19.5(r)0(.)]TJ
1.0137 -1.1116 TD
[(Subjects)-264.5(were)-255.2(instructed)-261.2(for)-262.4(510)-257.8(minutes)-257.8(only)-258(before)-262.3(the)]TJ
-1.0137 -1.1116 TD
[(measureme)-11(nts)-366.1(to)-365.2(explain)-373.2(and)-367.3(correct)-374.1(inhalation)-371(maneuvers)]TJ
0 -1.1174 TD
[(as)-279.6(recommended)-278.4(by)-272.9(the)-275.3(manufacturers)-279.2(of)-272.9(each)-272.8(device.)-278.6(They)]TJ
0 -1.1116 TD
[(could)-271.7(ask)-275(questions)-270.1(before)-273.8(measurements,)-271.1(but)-274.1(they)-270.6(were)-272.5(not)]TJ
T*
[(allowed)-402.8(to)-399.7(practice)-405.3(inhalation)-399.8(maneuvers.)-403.7(Steps)-398.1(of)-399.6(the)-396.3(in-)]TJ
0 -1.1174 TD
[(halation)-408.9(maneuver)-405.2(were)-410.7(as)-400.6(follows:)-407.3(\(1\))-406.4(preparation)-407.5(of)-405.3(the)]TJ
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[(devic)-8(e;)-303(\(2\))-308.5(long)-304(exhalation;)-309.9(\(3\))-308.5(attachment)-305.3(of)-307.4(the)-309.9(inhaler)-304(to)]TJ
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7.3837 0 0 6.5625 540.1132 294.2928 Tm
(4)Tj
9.845 0 0 9.845 543.7983 289.8708 Tm
(*)Tj
-23.6619 -1.3129 TD
(Comorbidities,)Tj
/F6 1 Tf
6.3229 0 TD
(n)Tj
/F5 1 Tf
.8292 0 TD
(\(%\))Tj
-6.1559 -1.0135 TD
[(Osteoporosis)-8052.6(1)-329.2(\(6\))-3527.2(4)-335(\(7\))]TJ
0 -1.0077 TD
[(Diabetes)-340.7(mellitus)-6183.9(1)-329.2(\(6\))-3527.2(3)-335(\(2\))]TJ
0 -1.0135 TD
[(Hypertension)-7875.6(4)-329.2(\(25\))-3027.2(2)-335(\(13\))]TJ
T*
[(Atherosclerosis)-7044.6(0)-329.2(\(0\))-3527.2(5)-335(\(33\)**)]TJ
T*
[(Myocardial)-337.1(infarct)-5687.6(0)-329.2(\(0\))-3527.2(2)-335(\(13\))]TJ
0 -1.0077 TD
[(Cerebral)-340.8(stroke)-7026.8(0)-329.2(\(0\))-3527.2(4)-335(\(27\)**)]TJ
-.9962 -1.3187 TD
[(Maintenance)-334.6(COPD)-340.4(therapy,)]TJ
/F6 1 Tf
12.1045 0 TD
(n)Tj
/F5 1 Tf
.8292 0 TD
(\(%\))Tj
-11.9375 -1.0135 TD
[(ICS)-7904.5(NA)-1875.2(12)-330.2(\(75\))-2526.2(14)-336(\(93\))]TJ
0 -1.0077 TD
[(LABA)-6739.5(NA)-1875.2(15)-330.2(\(94\))-2526.2(15)-336(\(100\))]TJ
0 -1.0135 TD
[(LAMA)-6520.5(NA)-1875.2(15)-330.2(\(94\))-2526.2(15)-336(\(100\))]TJ
T*
[(Theophylline)-4104.5(NA)-2376.1(4)-329.2(\(25\))-3027.2(7)-335(\(47\))]TJ
8.7511 0 0 8.7511 318.7841 146.211 Tm
(*)Tj
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(p)Tj
/F8 1 Tf
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(<)Tj
/F5 1 Tf
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[(0.05)-336(versus)-332.9(Control,)-329.9(**)]TJ
/F6 1 Tf
9.6074 0 TD
(p)Tj
/F8 1 Tf
.6673 0 TD
(<)Tj
/F5 1 Tf
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[(0.05)-329.6(versus)-332.9(S-COPD.)]TJ
6.5633 0 0 5.8334 318.7841 141.1653 Tm
(a)Tj
8.7511 0 0 8.7511 321.7322 137.2535 Tm
[(Chi-square)-337.2(test:)]TJ
/F6 1 Tf
6.7375 0 TD
(p)Tj
/F8 1 Tf
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(<)Tj
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(0.01.)Tj
6.5633 0 0 5.8334 318.7841 132.2078 Tm
(1)Tj
/F6 1 Tf
8.7511 0 0 8.7511 322.0724 128.296 Tm
(n)Tj
/F8 1 Tf
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(=)Tj
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(21;)Tj
6.5633 0 0 5.8334 348.3212 132.2078 Tm
(2)Tj
/F6 1 Tf
8.7511 0 0 8.7511 351.6093 128.296 Tm
(n)Tj
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(=)Tj
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(12;)Tj
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(3)Tj
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(n)Tj
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(=)Tj
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(20;)Tj
6.5633 0 0 5.8334 407.3952 132.2078 Tm
(4)Tj
/F6 1 Tf
8.7511 0 0 8.7511 410.6833 128.296 Tm
(n)Tj
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(=)Tj
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(14.)Tj
-11.8813 -1.0236 TD
[(AE-COPD,)-302.7(patients)-298.6(with)-293.1(exacerbated)-302.5(chronic)-296(obstructive)-300.1(pulmo-)]TJ
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[(nary)-500.4(disease;)-506.7(BMI,)-496.2(body)-500.7(mass)-502.7(index;)-503.5(CAT,)-505.3(chronic)-503.3(obstructive)]TJ
T*
[(pulmonary)-400.2(disease)-405.5(Assessment)-403.9(Test;)-402(GOLD,)-402.6(Global)-402.1(Initiative)-404(for)]TJ
0 -1.0301 TD
[(Chronic)-556.4(Obstructive)-561.5(Lung)-561.6(Disease;)-560.8(ICS,)-563.6(inhaled)-555.3(corticosteroid;)]TJ
0 -1.0236 TD
[(LABA,)-415.7(long-acting)-411.9(beta)]TJ
6.5633 0 0 5.8334 398.7212 82.0346 Tm
(2)Tj
8.7511 0 0 8.7511 401.9526 83.4519 Tm
[(-agonist;)-417.9(LAMA,)-410.5(long-acting)-418.4(muscarinic)]TJ
-10.4107 -1.0236 TD
[(antagonist;)-391(mMRC,)-386.4(modied)-390.8(Medical)-385.2(Research)-396.4(Council;)-385.7(NA,)-393.6(not)]TJ
T*
[(applicable;)-738.3(S-COPD,)-732.9(patients)-732.6(with)-740.1(stable)-736.2(chronic)-736.5(obstructive)]TJ
T*
[(pulmonary)-328.9(disease;)-338.3(VAS,)-333.9(visual)-333.4(analog)-331(scale.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(REPEATABILITY)-343.1(OF)-331.2(INHALER)-340.8(USE)-333.7(IN)-335.1(COPD)-31627.5(273)]TJ
ET
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