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Browsing by Author "Csont, Tamás Bálint"

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Alternative Splicing of NOX4 in the Failing Human Heart

Varga, Zoltán; Pipicz, Márton; Baán, Júlia Aliz; Baranyai T; Koncsos, Gábor; Leszek P; Kusmierczyk M; Sanchez-Cabo F; Garcia-Pavia P; Brenner, Gábor; Giricz, Zoltán; Csont, Tamás Bálint; Mendler, Luca; Lara-Pezzi E; Pacher, Pál; Ferdinandy, Péter (2017)

Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. ...
Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference

Sárközy, Márta; Fekete, Veronika; Szűcs, Gergő; Török, Szilvia; Szűcs, Csilla; Barkányi, Judit; Varga, Zoltán; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

BACKGROUND: Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, ...
Cardioprotection by Farnesol: Role of the Mevalonate Pathway

Szűcs, Gergő; Murlasits, Zsolt; Török, Szilvia; Kocsis-Fodor, Gabriella; Pálóczi, János; Görbe, Anikó; Csont, Tamás Bálint; Csonka, Csaba; Ferdinandy, Péter (2013)

Purpose: Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart. Methods: Male Wistar rats were treated orally with 0.2, 1, ...
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide

Csonka, Csaba; Kupai, Krisztina; Bencsik, Péter; Görbe, Anikó; Pálóczi, János; Zvara, Ágnes; Puskás, László; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

It has been previously shown that hyperlipidemia interferes with cardioprotective mechanisms. Here we investigated the interaction of hyperlipidemia with cardioprotection induced by pharmacological activators of ATP-sensitive ...
Cytoprotection by the NO-donor SNAP against ischemia/reoxygenation injury in mouse embryonic stem cell-derived cardiomyocytes

Görbe, Anikó; Varga, Zoltán; Pálóczi, János; S. Rungarunlert; N. Klincumhom; Pirity, Melinda; R. Madonna; T. Eschenhagen; Dinnyés, András; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

Embryonic stem cell (ESC)-derived cardiomyocytes are a promising cell source for the screening for potential cytoprotective molecules against ischemia/reperfusion injury, however, little is known on their behavior ...
Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet

Csont, Tamás Bálint; Sárközy, Márta; Szűcs, Gergő; Szűcs, Csilla; Barkányi, Judit; Bencsik, Péter; Gáspár, Renáta; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Ferdinandy, Péter (2013)

BACKGROUND: Although complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia ...
Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury

Pálóczi, János; Varga, Zoltán V; Apáti, Ágota; Szebényi, Kornélia; Sarkadi, Balázs; Rosalinda, Madonna; Raffaele, De Caterina; Csont, Tamás Bálint; Thomas, Eschenhagen; Ferdinandy, Péter; Görbe, Anikó (2016)

Background and Aims. Human embryonic stem cell- (hESC-) derived cardiomyocytes are one of the useful screening platforms of potential cardiocytoprotective molecules. However, little is known about the behavior of these ...
Ischemic postconditioning alters the gene expression pattern of the ischemic heart

Csonka, Csaba; Szűcs, Gergő; Varga-Orvos, Zoltán; Bencsik, Péter; Csont, Tamás Bálint; Zvara, Ágnes; Puskás, László; Ferdinandy, Péter (2014)

To profile changes in gene expression in response to ischemic postconditioning, isolated rat hearts were subjected to 30 min of regional ischemia followed by 120 min of reperfusion with or without postconditioning. At the ...
Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas

Csonka, Csaba; Baranyai, Tamás; Tiszlavicz, László; Fébel, Hedvig; Szűcs, Gergő; Varga, Zoltán; Sárközy, Márta; Puskás, László; Antal, Otilia Tamara; Siska, Andrea; Földesi, Imre; Ferdinandy, Péter; Czakó, László; Csont, Tamás Bálint (2017)
JDP2 overexpression provokes cardiac dysfunction in mice

Heger J; Bornbaum J; Wurfel A; Hill C; Brockmann N; Gáspár, Renáta; Pálóczi, János; Varga, Zoltán; Sárközy, Márta; Bencsik, Péter; Csont, Tamás Bálint; Török, Szilvia; Kojonazarov B; Schermuly RT; Bongler K; Parahuleva M; Ferdinandy, Péter; Schulz R; Euler G (2018)

The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing ...
Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart

Pipicz, Márton; Kocsis-Fodor, Gabriella; Sarvary-Arantes L; Bencsik, Péter; Varga, Zoltán; Ferdinandy, Péter; Csont, Tamás Bálint (2017)

Administration of low-dose endotoxin (lipopolysaccharide, LPS) 24 h before a lethal ischemia induces pharmacological late preconditioning. The exact mechanism of this phenomenon is not clear. Here we aimed to investigate ...
Measurement of NO in biological samples

Csonka, Csaba; Páli, Tibor; Bencsik, Péter; Görbe, Anikó; Ferdinandy, Péter; Csont, Tamás Bálint (2015)
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats

Sárközy, Márta; Zvara, Ágnes; Gyemant N; Fekete V; Kocsis-Fodor, Gabriella; Pipis, Judit; Szűcs, Gergő; Csonka, Csaba; Puskás, László; Ferdinandy, Péter; Csont, Tamás Bálint (2013)

ABSTRACT: BACKGROUND: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac ...
MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

Varga, Zoltán; Kupai, Krisztina; Szűcs, Gergő; Gáspár, Renáta; Pálóczi, János; Faragó, Nóra; Zvara, Ágnes; Puskás, László; Rázga, Zsolt; Tiszlavicz, László; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Ferdinandy, Péter; Csont, Tamás Bálint (2013)

Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether ...
MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs

Varga, Zoltán; Zvara, Ágnes; Faragó, Nóra; Kocsis-Fodor, Gabriella; Pipicz, Márton; Gáspár, Renáta; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Puskás, László; Thum T; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic ...
Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective

Bencsik, Péter; Pálóczi, János; Kocsis-Fodor, Gabriella; Pipis, Judit; Belecz, István; Varga, Zoltán; Csonka, Csaba; Görbe, Anikó; Csont, Tamás Bálint; Ferdinandy, Péter (2014)

Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered ...
Myocardial postconditioning is lost in vascular nitrate tolerance

Fekete V; Murlasits, Zsolt; Aypar E; Bencsik, Péter; Sárközy, Márta; Szénási, Gábor; Ferdinandy, Péter; Csont, Tamás Bálint (2013)

Organic nitrates play an important role in the therapy of ischemic heart disease, however, their clinical application is limited by the development of vascular nitrate tolerance. We have previously shown attenuation of the ...
Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats

Kiss, Krisztina; Csonka, Csaba; Pálóczi, János; Pipis, Judit; Görbe, Anikó; Kocsis-Fodor, Gabriella; Murlasits Z; Sárközy, Márta; Szűcs, Gergő; Holmes CP; Pan Y; Bhandari A; Csont, Tamás Bálint; Shamloo M; Woodburn KW; Ferdinandy, Péter; Bencsik, Péter (2016)

Erythropoietin (EPO) has been shown to protect the heart against acute myocardial infarction in pre-clinical studies, however, EPO failed to reduce infarct size in clinical trials and showed significant safety problems. ...
Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain

Szalay, Csaba Imre; Erdélyi, Katalin; Kökény, Gábor; Lajtar E; Godo M; Revesz C; Kaucsár, Tamás; Kiss, Norbert; Sárközy, Márta; Csont, Tamás Bálint; Krenács, Tibor; Szénási, Gábor; Pacher, Pál; Hamar, Péter (2015)

Chronic renal fibrosis is the final common pathway of end stage renal disease caused by glomerular or tubular pathologies. Genetic background has a strong influence on the progression of chronic renal fibrosis. We recently ...
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients

Bencsik, Péter; Sasi, Viktor; Kiss, Krisztina; Kupai, Krisztina; Kolossváry, Márton József; Maurovich-Horvat, Pál; Csont, Tamás Bálint; Ungi I; Merkely, Béla Péter; Ferdinandy, Péter (2015)

AIMS: Peroxynitrite - matrix metalloproteinase (MMP) signaling has been shown to contribute to myocardial ischemia/reperfusion injury and heart failure and to be influenced by hyperlipidemia in preclinical models. ...

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