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Browsing by Author "Csuka, Dorottya"

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A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab

Galic, Slobodan; Csuka, Dorottya; Prohászka, Zoltán; Turudic, Daniel; Dzepina, Petra; Milosevic, Danko (2019)

This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first ...
Activation of the ficolin-lectin pathway during attacks of hereditary angioedema.

Csuka, Dorottya; Lea Munthe-Fog; Estrid Hein; Zotter, Zsuzsanna; Prohászka, Zoltán; Farkas, Henriette; Varga, Lilian; Peter Garred (2014)
Analysis of linear antibody epitopes on factor H and CFHR1 using sera of patients with autoimmune atypical hemolytic uremic syndrome

Trojnár, Eszter; Józsi, Mihály; Uray, Katalin; Csuka, Dorottya; Szilágyi, Ágnes; Milosevic D; Stojanovic VD; Spasojevic ́ B; Rusai K; Müller T; Arbeiter K; Kelen, Kata; Szabó, Attila J; Reusz, György S; Hyvärinen S; Jokiranta TS; Prohászka, Zoltán (2017)
A novel assay to quantitate MASP-2/ficolin-3 complexes in serum.

Csuka, Dorottya; Munthe-Fog L; Skjoedt MO; Hein E; Bay JT; Varga, Lilian; Füst, György; Garred P (2013)

Ficolin-1, -2 and -3 are recognition molecules in the lectin complement pathway and form complexes with serine proteases named MASP-1, -2 and -3 and two nonenzymatic proteins. MASP-2 is the main initiator of lectin pathway ...
Association of low ficolin-lectin pathway parameters with Cardiac Syndrome X

Horváth, Zsófia; Csuka, Dorottya; Vargova K; Lee S; Varga, Lilian; Garred P; Préda, István; Zsamboki ET; Prohászka, Zoltán; Kiss, Róbert Gábor (2016)

In patients with typical angina pectoris, inducable myocardial ischaemia and macroscopically normal coronaries (Cardiac Syndrome X, CSX) significantly elevated plasma level of terminal complement complex (TCC), the common ...
A systematic analysis of the complement pathways in patients with neuromyelitis optica indicates alteration but no activation during remission

Veszeli, Nóra; Füst, György; Csuka, Dorottya; Trauninger, Anita; Bors L; Rózsa, Csilla; Nagy Z; Jobbágy Z; Eizler K; Prohászka, Zoltán; Varga, Lilian; Illés, Zsolt László (2014)
C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

Garam, Nóra; Prohászka, Zoltán; Szilágyi, Ágnes; Christof, Aigner; Alice, Schmidt; Martina, Gaggl; Gere, Sunder-Plassmann; Bajcsi, Dóra; Jürgen, Brunner; Alexandra, Dumfarth; Daniel, Cejka; Stefan, Flaschberger; Hana, Flögelova; Ágnes, Haris; Ágnes, Hartmann; Andreas, Heilos; Thomas, Mueller; Rusai, Krisztina; Klaus, Arbeiter; Johannes, Hofer; Dániel, Jakab; Mária, Sinkó; Erika, Szigeti; Csaba, Bereczki; Viktor, Janko; Kelen, Kata; Reusz, György; Szabó, Attila; Nóra, Klenk; Krisztina, Kóbor; Nika, Kojc; Maarten, Knechtelsdorfer; Mario, Laganovic; Adrian, Catalin Lungu; Anamarija, Meglic; Rina, Rus; Tanja, Kersnik-Levart; Ernesta, Macioniene; Marius, Miglinas; Anna, Pawłowska; Tomasz, Stompór; Ludmila, Podracka; Michael, Rudnicki; Gert, Mayer; Romana, Rysava; Jana, Reiterova; Marijan, Saraga; Tomáš, Seeman; Jakub, Zieg; Eva, Sládková; Szabó, Tamás; Andrei, Capitanescu; Simona, Stancu; Miroslav, Tisljar; Kresimir, Galesic; Tislér, András; Inga, Vainumäe; Martin, Windpessl; Tomas, Zaoral; Galia, Zlatanova; Csuka, Dorottya (2019)
Carboxiterminal pro-endothelin-1 as an endothelial cell biomarker in thrombotic thrombocytopenic purpura

Mikes, Bálint; Sinkovits, György; Farkas, Péter; Csuka, Dorottya; Razso K; Réti, Marienn Györgyi; Radvanyi G; Demeter, Judit; Prohászka, Zoltán (2016)

Thrombotic thrombocytopenic purpura (TTP) is characterised by the deficiency of the von Willebrand factor (VWF) cleaving protease (ADAMTS-13). Although several observations indicate an important role of endothelial activation ...
Complement activation and its prognostic role in post-cardiac arrest patients

Jenei, Zsigmond; Zima, Endre István; Csuka, Dorottya; Munthe-Fog L; Hein E; Széplaki, Gábor; Becker, Dávid; Karádi, István; Prohászka, Zoltán; Garred P; Merkely, Béla Péter (2014)

Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood. Moreover, predicting the prognosis of comatose, post-cardiac-arrest ...
Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies

Farkas, Péter; Csuka, Dorottya; Mikes, Bálint; Sinkovits, György; Réti, Marienn Györgyi; Németh, Endre; Rácz, Kristóf; Madách, Krisztina; Gergely, Mihály; Demeter, Judit; Prohászka, Zoltán (2017)

BACKGROUND: The secondary forms of hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (secondary TMA) emerge as complications of coexisting diseases. OBJECTIVES: We hypothesized that secondary TMA could be ...
Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency.

Csuka, Dorottya; Veszeli, Nóra; Imreh E; Zotter, Zsuzsanna; Skopál, Judit; Prohászka, Zoltán; Varga, Lilian; Farkas, Henriette (2015)

BACKGROUND: The activation of plasma enzyme systems contributes to hereditary angioedema attacks. We aimed to study the activation markers of the fibrinolytic, coagulation, and contact systems in a larger number of paired ...
Early Increase in Complement Terminal Pathway Activation Marker sC5b-9 Is Predictive for the Development of Thrombotic Microangiopathy after Stem Cell Transplantation

Horváth, Orsolya; Kallay K; Csuka, Dorottya; Mező, Blanka; Sinkovits, György; Kassa, Csaba; Strehn A; Csordas K; Sinkó, János; Prohászka, Zoltán; Kriván, Gergely (2018)

Hematopoietic stem cell transplantation (HSCT)-associated thrombotic microangiopathy (TA-TMA) is a multifactorial complication, and its prediction is largely unresolved. Our aim was to analyze changes of complement profile ...
Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis

Csuka, Dorottya; Czirják, László; Hóbor, Renáta; Illés, Zsolt László; Bánáti, Miklós János; Rajczy K; Tordai, Attila; Füst, György (2013)

INTRODUCTION: Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients ...
Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura.

Mikes B; Sinkovits G; Farkas, Péter; Csuka, Dorottya; Schlammadinger A; Razso K; Demeter, Judit; Domján, Gyula; Reti M; Prohászka, Zoltán (2014)

INTRODUCTION: Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the ...
Endothelial cell activation during edematous attacks of hereditary angioedema types I and II.

Kajdácsi, Erika; Jani, Péter Károly; Csuka, Dorottya; Varga, Lilian; Prohászka, Zoltán; Farkas, Henriette; Cervenak, László (2014)
Endothelial Cell Function in Patients with Hereditary Angioedema: Elevated Soluble E-selectin Level During Inter-attack Periods

Czúcz J; Schaffer G; Csuka, Dorottya; Walentin S; Kunde J; Prohászka, Zoltán; Farkas, Henriette; Cervenak, László (2012)
Frequency of the virilising effects of attenuated androgens reported by women with hereditary angioedema.

Zotter, Zsuzsanna; Veszeli, Nóra; Csuka, Dorottya; Varga, Lilian; Farkas, Henriette (2014)
Functional analysis of the mannose-binding lectin complement pathway in normal pregnancy and preeclampsia

Csuka, Dorottya; Molvarec, Attila; Derzsy, Zoltán; Varga, Lilian; Füst, György; Rigó, János Jr.; Prohászka, Zoltán (2010)

Preeclampsia is a severe complication of pregnancy characterized by hypertension and proteinuria developing after midgestation. Previous studies have shown increased complement activation in normal and preeclamptic ...
Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients

Frida C Mohlin; Sara C. Nilsson; Tanja Kersnik Levart; Ema Golubovic; Krisztina Rusai; Thomas Müller-Sacherer; Klaus Arbeiter; Pállinger, Éva; Szarvas, Nóra; Csuka, Dorottya; Szilágyi, Ágnes; Bruno O. Villoutreix; Prohászka, Zoltán; Anna M. Blom (2015)
Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome

Szarvas Nóra; Szilágyi, Ágnes; Csuka, Dorottya; Takács Beáta; Rusai, Krisztina; Müller Thomas; Arbeiter Klaus; Réti Marienn; Haris Ágnes; Wágner, László József; Török, Szilárd; Kelen, Kata; Szabó, Attila; Reusz, György; Morgan B Paul; Prohászka, Zoltán (2016)

Abstract Atypical hemolytic uremic syndrome (aHUS) is a rare disorder caused by dysregulation of the complement alternative pathway, and associated with mutations in genes of complement components and regulators. In the ...

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