tallózása szerző szerint "Jakus, Zoltán"

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Hematopoietic or osteoclast-specific deletion of Syk leads to increased bone mass in experimental mice

Csete, Dániel; Simon, Edina; Alatshan, Ahmad; Aradi, Petra; Dobó-Nagy, Csaba; Jakus, Zoltán; Benkő, Szilvia; Győri, Dávid Sándor; Mócsai, Attila (2019)
Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Németh, Tamás; Futosi, Krisztina; Szabó, Marcell; Aradi, Petra; Saito Takashi; Mócsai, Attila; Jakus, Zoltán (2019)
Lymphatic function is required prenatally for lung inflation at birth

Jakus, Zoltán; Gleghorn JP; Enis DR; Sen A; Chia S; Liu X; Rawnsley DR; Yang Y; Hess PR; Zou Z; Yang J; Guttentag SH; Nelson CM; Kahn ML (2014)

Mammals must inflate their lungs and breathe within minutes of birth to survive. A key regulator of neonatal lung inflation is pulmonary surfactant, a lipoprotein complex which increases lung compliance by reducing alveolar ...
Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage

Outtz, Reed Hasina; Wang, Liqing; Sonett, Jarrod; Chen, Mei; Yang, Jisheng; Li, Larry; Aradi, Petra; Jakus, Zoltán; D'Armiento, Jeanine M; Hancock, Wayne W; Kahn, Mark L (2019)

The lung is a specialized barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in order to maintain effective gas exchange. Lymphatic vessels are important for these functions in other ...
Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling

Pawlak, John B; Bálint, László; Lim, Lillian; Ma, Wanshu; Davis, Reema B; Benyó, Zoltán; Soares, Michael J; Oliver, Guillermo; Kahn, Mark L; Jakus, Zoltán; Caron, Kathleen M (2019)

Molecular heterogeneity of endothelial cells underlies their highly-specialized functions during changing physiological conditions within diverse vascular beds. For example, placental spiral arteries (SAs) undergo remarkable ...
Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels

Bálint, László; Ocskay, Zsombor; Deák, Bálint András; Aradi, Petra; Jakus, Zoltán (2020)
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3

Gambardella L; Anderson KE; Jakus, Zoltán; Kovács, Miklós; Voigt S; Hawkins PT; Stephens L; Mócsai, Attila; Vermeren S (2013)

ARAP3, a GTPase activating protein for Rho and Arf family GTPases, is one of many phosphoinositide 3-OH kinase (PI3K) effectors. In this study, we investigate the regulatory input of PI3K upstream of ARAP3 by analyzing ...
Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification

Tőkési, Natália; Kozák, Eszter Zita; Fülöp, Krisztina; Dedinszki, Dóra; Hegedűs, Nikolett; Király, Bálint; Szigeti, K; Ajtay, Kitti; Jakus, Zoltán; Zaworski, J; Letavernier, E; Pomozi, Viola; Váradi, András (2020)

Trauma-induced calcification is the pathological consequence of complex injuries which often affect the central nervous system and other parts of the body simultaneously. We demonstrated by an animal model recapitulating ...
Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth

Szoták-Ajtay, Kitti; Szõke, Dániel; Kovács, Gábor; Andréka, Judit; Brenner, Gábor B; Giricz, Zoltán; Penninger, Josef; Kahn, Mark L; Jakus, Zoltán (2020)
The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

Zhou, Zinan; Rawnsley, David R; Goddard, Lauren M; Pan, Wei; Cao, Xin-Jung; Jakus, Zoltán; Hui, Zheng; Jisheng, Yang; Simon, Arthur; Kevin, J Whitehead; Dean, Li; Bin, Zhou; Benjamin, A Garcia; Xiangjian, Zheng; Mark, L Kahn (2015)

The cerebral cavernous malformation (CCM) pathway is required in endothelial cells for normal cardiovascular development and to prevent postnatal vascular malformations, but its molecular effectors are not well defined. ...
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

Kovács, Miklós; Németh, Tamás; Jakus, Zoltán; Sitaru C; Simon, Edina; Futosi, Krisztina; Botz, Bálint; Helyes, Zsuzsanna; Lowell CA; Mócsai, Attila (2014)

Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly understood. We show that Src family kinases play a critical role ...

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tallózása szerző szerint "Jakus, Zoltán"

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