tallózása szerző szerint "Klepetko W"

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A New Mechanism for Pillar Formation during Tumor-Induced Intussusceptive Angiogenesis

Paku, Sándor; Dezső, Katalin; Bugyik, Edina; Tóvári, József; Tímár, József; Nagy, Péter; Laszlo, Viktoria; Klepetko W; Döme, Balázs (2011)

One of the hallmarks of intussusceptive angiogenesis is the development of intraluminal connective tissue pillars. The exact mechanism of pillar formation has not yet been elucidated. By using electron and confocal microscopy, ...
Apelin expression in human non-small cell lung cancer: Role in angiogenesis and prognosis

Berta, Judit; Kenessey, István; Dobos J; Tóvári, József; Klepetko W; Ankersmit HJ; Hegedűs, Balázs; Rényi-Vámos, Ferenc István; Varga, János; Lorincz Zs; Paku, Sándor; Ostoros, Gyula; Rózsás, Anita; Tímár, József; Döme, Balázs (2010)
Apelin promotes lymphangiogenesis and lymph node metastasis

Berta, Judit; Hoda MA; Laszlo, Viktoria; Rozsas A; Garay, Tamás; Torok S; Grusch M; Berger W; Paku, Sándor; Rényi-Vámos, Ferenc István; Masri B; Tóvári, József; Groger M; Klepetko W; Hegedűs, Balázs; Döme, Balázs (2014)

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been ...
Cell migration or cytokinesis and proliferation? - revisiting the "go or grow" hypothesis in cancer cells in vitro.

Garay, Tamás; Juhasz E; Molnár, Eszter; Eisenbauer M; Czirók, András; Dekan B; Laszlo, Viktoria; Hoda MA; Döme, Balázs; Tímár, József; Klepetko W; Berger W; Hegedűs, Balázs (2013)

The mortality of patients with solid tumors is mostly due to metastasis that relies on the interplay between migration and proliferation. The "go or grow" hypothesis postulates that migration and proliferation spatiotemporally ...
Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Klikovits T; Stockhammer P; Laszlo V; Dong Y; Hoda MA; Ghanim B; Opitz I; Frauenfelder T; Nguyen-Kim TDL; Weder W; Berger W; Grusch M; Aigner C; Klepetko W; Döme, Balázs; Rényi-Vámos, Ferenc István; Oehler R; Hegedűs, Balázs (2017)

Only limited information is available on the role of complement activation in malignant pleural mesothelioma (MPM). Thus, we investigated the circulating and tissue levels of the complement component 4d (C4d) in MPM. Plasma ...
Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma.

Ghanim B; Hoda MA; Klikovits T; Winter MP; Alimohammadi A; Grusch M; Döme Balázs; Arns B; Schenk P; Jakopovic M; Samarzija M; Brcic L; Filipits M; Laszlo Viktoria; Klepetko W; Berger W; Hegedüs Balázs (2014)

Background:To investigate the clinical utility of pretreatment plasma fibrinogen levels in malignant pleural mesothelioma (MPM) patients.Methods:A retrospective multicenter study was performed in histologically proven MPM ...
Distinct epidemiology and clinical consequence of classic versus rare EGFR mutations in lung adenocarcinoma.

Lohinai, Zoltán; Hoda MA; Fábián, Katalin; Ostoros, Gyula; Rásó, Erzsébet; Barbai, Tamás; Tímár, József; Kovalszky, Ilona; Cserepes, Tamás Mihály; Laszlo, Viktoria; Grusch M; Berger W; Klepetko W; Moldvay, Judit; Döme, Balázs; Hegedűs, Balázs (2015)

INTRODUCTION:: While classic sensitizing mutations of epidermal growth factor receptor (EGFR) are positive predictive markers for EGFR tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma, there are rare EGFR mutations ...
EGFR, BRAF and KRAS Status in Patients Undergoing Pulmonary Metastasectomy from Primary Colorectal Carcinoma: A Prospective Follow-Up Study

Schweiger T; Hegedűs, Balázs; Nikolowsky C; Hegedűs, Zita; Szirtes, Ildikó; Mair R; Birner P; Döme, Balázs; Lang, György; Klepetko W; Ankersmit HJ; Hoetzenecker K (2014)

BACKGROUND: Pulmonary metastasectomy is an integral part of the interdisciplinary treatment of patients with pulmonary metastases (PMs) from colorectal carcinoma (CRC). Although alterations in the epidermal growth factor ...
Epigenetic down-regulation of integrin alpha7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma

Laszlo V; Hoda MA; Garay, Tamás; Pirker C; Ghanim B; Klikovits T; Dong YW; Rózsás, Anita; Kenessey, István; Szirtes, Ildikó; Grusch M; Jakopovic M; Samarzija M; Brcic L; Kern I; Rozman A; Popper H; Zochbauer-Muller S; Heller G; Altenberger C; Ziegler B; Klepetko W; Berger W; Döme, Balázs; Hegedűs, Balázs (2015)

Malignant pleural mesothelioma (MPM) is a devastating malignancy characterized by invasive growth and rapid recurrence. The identification and inhibition of molecular components leading to this migratory and invasive ...
Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma

Rozsas A; Berta, Judit; Rojko L; Horvath LZ; Keszthelyi M; Kenessey, István; Laszlo, Viktoria; Berger W; Grusch M; Hoda MA; Torok S; Klepetko W; Rényi-Vámos, Ferenc István; Hegedűs, Balázs; Döme, Balázs; Tóvári, József (2013)

Recombinant human erythropoietins (rHuEPOs) are used to treat cancer-related anemia. Recent preclinical studies and clinical trials, however, have raised concerns about the potential tumor-promoting effects of these drugs. ...
Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy

Schelch K; Hoda MA; Klikovits T; Munzker J; Ghanim B; Wagner C; Garay, Tamás; Laszlo, Viktoria; Setinek U; Döme, Balázs; Filipits M; Pirker C; Heffeter P; Selzer E; Tóvári, József; Török, Szilvia; Kenessey, István; Holzmann K; Grasl-Kraupp B; Marian B; Klepetko W; Berger W; Hegedűs, Balázs; Grusch M (2014)

RATIONALE: Malignant pleural mesothelioma is an aggressive malignancy characterized by frequent resistance to chemo- and radiotherapy, poor outcome, and limited therapeutic options. Fibroblast growth factors (FGFs) and ...
Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis

Kirschner MB; Pulford E; Hoda MA; Rózsás, Anita; Griggs K; Cheng YY; Edelman JJ; Kao SC; Hyland R; Dong Y; Laszlo V; Klikovits T; Vallely MP; Grusch M; Hegedűs, Balázs; Döme, Balázs; Klepetko W; van Zandwijk N; Klebe S; Reid G (2015)

BACKGROUND: Fibulin-3 (FBLN3) was recently presented as a promising novel biomarker for malignant pleural mesothelioma (MPM), warranting independent validation studies. METHODS: ELISA was used to measure cellular and ...
Inhibition of c-Met with the Specific Small Molecule Tyrosine Kinase Inhibitor SU11274 Decreases Growth and Metastasis Formation of Experimental Human Melanoma.

Kenessey I; Keszthelyi M; Krámer ZF,; Berta J; Ádám A; Dobos J; Mildner M; Flachner B; Cseh S; Barna G; Szokol B; Őrfi L; Kéri G; Döme B; Klepetko W; Tímár J; Tóvári J (2010)

The hepatocyte growth factor/scatter factor (HGF/SF) tyrosine kinase (TK) receptor c-Met plays a crucial role in the development of the invasive phenotype of tumors and thus represents an attractive candidate for targeted ...
Intrathoracic solitary fibrous tumor - an international multicenter study on clinical outcome and novel circulating biomarkers

Ghanim B; Hess S; Bertoglio P; Celik A; Bas A; Oberndorfer F; Melfi F; Mussi A; Klepetko W; Pirker C; Berger W; Harmati I; Farkas A; Jan Ankersmit H; Döme, Balázs; Fillinger J; Aigner C; Hegedűs, Balázs; Rényi-Vámos, Ferenc István; Lang, György (2017)

Intrathoracic solitary fibrous tumor (SFT) is a rare disease. Radical resection is the standard of care. However, estimating prognosis and planning follow-up and treatment strategies remains challenging. Data were ...
Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study

Ghanim B; Klikovits T; Hoda MA; Lang, György; Szirtes, Ildikó; Setinek U; Rozsas A; Rényi-Vámos, Ferenc István; Laszlo V; Grusch M; Filipits M; Scheed A; Jakopovic M; Samarzija M; Brcic L; Stancic-Rokotov D; Kern I; Rozman A; Dekan G; Klepetko W; Berger W; Glasz, Tibor; Döme, Balázs; Hegedűs, Balázs (2015)

BACKGROUND: Estimating the prognosis in malignant pleural mesothelioma (MPM) remains challenging. Thus, the prognostic relevance of Ki67 was studied in MPM. METHODS: Ki67 index was determined in a test cohort of 187 cases ...
KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS-mutation and bone metastasis

Lohinai Zoltán; Klikovits Thomas; Moldvay Judit; Ostoros Gyula; Rásó Erzsébet; Tímár József; Fábián Katalin; Kovalszky Ilona; Kenessey István; Aigner C; Rényi-Vámos Ferenc István; Klepetko W; Döme Balázs; Hegedűs Balázs (2017)
Lack of Angiogenesis in Experimental Brain Metastases

Bugyik, Edina; Dezső, Katalin; Reiniger, Lilla; Laszlo, Viktoria; Tóvári, József; Tímár, József; Nagy, Péter; Klepetko W; Döme, Balázs; Paku, Sándor (2011)

Angiogenesis is believed to be essential for the growth of metastatic tumors in the brain. We analyzed the vascularization of tumors formed by 4 epithelial cell lines (C38, ZR75, HT25, and H1650) and a fibrosarcoma (HT1080) ...
Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors

Torok S; Rezeli M; Kelemen O; Vegvari A; Watanabe K; Sugihara Y; Tisza A; Marton T; Kovacs I; Tovari J; Laszlo V; Helbich TH; Hegedűs, Balázs; Klikovits T; Hoda MA; Klepetko W; Paku S; Marko-Varga G; Dome B (2017)

Resistance mechanisms against antiangiogenic drugs are unclear. Here, we correlated the antitumor and antivascular properties of five different antiangiogenic receptor tyrosine kinase inhibitors (RTKIs) (motesanib, pazopanib, ...
Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells.

Garay, Tamás; Kenessey, István; Molnár, Eszter; Juhasz E; Réti, Andrea; Laszlo V; Rozsas A; Dobos J; Döme, Balázs; Berger W; Klepetko W; Tóvári, József; Tímár, József; Hegedűs, Balázs (2015)

While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we ...
Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

Schweiger T; Nikolowsky C; Starlinger P; Traxler D; Zimmermann M; Birner P; Hegedűs, Balázs; Döme, Balázs; Bergmann M; Mildner M; Klepetko W; Hoetzenecker K; Ankersmit HJ (2015)

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tallózása szerző szerint "Klepetko W"

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