tallózása szerző szerint "Nagy, Noémi"

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Activity and complexes of mTOR in diffuse large B-cell lymphomas-a tissue microarray study

Sebestyén, Anna; Sticz TB; Márk, Ágnes; Hajdu, Melinda; Tímár, Botond; Nemes, Karolina; Nagy, Noémi; Váradi, Zsófia; Kopper, László (2012)

Diffuse large B-cell lymphoma is a heterogeneous group of diseases with different responses to therapy. Targeting mTOR (mammalian target of rapamycin) offers a new approach to improve the treatment. mTOR inhibitors are ...
Az mTOR jelút aktivitását befolyásoló tényezők és szabályozási folyamatok Hodgkin lymphoma modellekben és szöveti mintákban

Nagy, Noémi (2018)
Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease - a combined tissue microarray, in vitro and in vivo study.

Márk, Ágnes; Hajdu, Melinda; Varadi Z; Sticz TB; Nagy, Noémi; Csomor, Judit; Berczi L; Varga V; Csóka, Monika; Kopper, László; Sebestyén, Anna (2013)

BACKGROUND: Targeting signaling pathways is an attractive approach in many malignancies. The PI3K/Akt/mTOR pathway is activated in a number of human neoplasms, accompanied by lower overall and/or disease free survival. ...
Discrepancy Between Low Levels of mTOR Activity and High Levels of P-S6 in Primary Central Nervous System Lymphoma May Be Explained by PAS Domain-Containing Serine/Threonine-Protein Kinase-Mediated Phosphorylation

Marosvári, Dóra; Nagy, Noémi; Kriston, Csilla; Deak B; Hajdu, Melinda; Bödör, Csaba; Csala, Irén; Bago AG; Szállási, Zoltán; Sebestyén, Anna; Reiniger, Lilla (2018)

The primary aim of this study was to determine mTOR-pathway activity in primary central nervous system lymphoma (PCNSL), which could be a potential target for therapy. After demonstrating that p-S6 positivity largely ...
Expression of certain leukemia/lymphoma related microRNAs and its correlation with prognosis in childhood acute lymphoblastic leukemia

Nemes, Karolina; Csóka, Monika; Nagy, Noémi; Márk, Ágnes; Zsófia Váradi; Titanilla Dankó; Kovács, Gábor; Kopper, László; Sebestyén, Anna (2015)
Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation

Nagy, Noémi; Hajdu, Melinda; Márk, Ágnes; Király, Péter Attila; Toth M; Danko T; Csóka, Monika; Sebestyén, Anna (2016)

Growing evidence suggests that deregulation of signalling elements of Notch and mammalian target of rapamycin (mTOR) pathways contribute to tumorigenesis. These signals play important roles in cellular functions and ...
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.

Gángó, Ambrus; Mózes, Réka; Boha Z; Kajtár, Béla; Tímár, Botond; Király, Péter Attila; Kiss, Richárd; Fesus V; Nagy, Noémi; Demeter, Judit; Korosmezey G; Borbényi, Zita; Marton, Imelda; Szoke A; Masszi, Tamás; Farkas, Péter; Várkonyi, Judit; Plander M; Posfai E; Egyed, Miklós; Pal K; Radvanyi G; Hamed A; Csomor, Judit; Matolcsy, András; Alpár, Donát; Bödör, Csaba (2018)

BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the ...
Rapamycin can restore the negative regulatory function of transforming growth factor beta 1 in high grade lymphomas

Sebestyén, Anna; Márk, Ágnes; Hajdu, Melinda; Nagy, Noémi; Molnár A; Végső, Gyula; Barna, Gábor; Kopper, László (2015)
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

Hujber, Zoltán; Petővári, Gábor; Szoboszlai, Norbert; Danko T; Nagy, Noémi; Kriston, Csilla; Krencz, Ildikó; Paku, Sándor; Ozohanics, Olivér; Drahos, László; Jeney, András; Sebestyén, Anna (2017)

BACKGROUND: Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms ...

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tallózása szerző szerint "Nagy, Noémi"

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