tallózása szerző szerint "Pacher, Pál"

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  • Alternative Splicing of NOX4 in the Failing Human Heart 
    Varga, Zoltán; Pipicz, Márton; Baán, Júlia Aliz; Baranyai T; Koncsos, Gábor; Leszek P; Kusmierczyk M; Sanchez-Cabo F; Garcia-Pavia P; Brenner, Gábor; Giricz, Zoltán; Csont, Tamás Bálint; Mendler, Luca; Lara-Pezzi E; Pacher, Pál; Ferdinandy, Péter (2017)
    Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. ...
  • Cardiac Nitric Oxide Signalling in Metabolic Syndrome 
    Pechanova O; Varga, Zoltán; Cebova M; Giricz, Zoltán; Pacher, Pál; Ferdinandy, Péter (2015)
    It is well documented that metabolic syndrome (i.e. a group of risk factors, such as abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low cholesterol level in ...
  • Definition of hidden drug cardiotoxicity 
    Ferdinandy, Péter; Baczkó, István; Bencsik, Péter; Giricz, Zoltán; Görbe, Anikó; Pacher, Pál; Varga, Zoltán; Varró, András; Schulz, R (2019)
    Unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Since the original observations in the mid-90s, it has been well established that ...
  • Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress 
    Koncsos, Gábor; Varga, Zoltán; Baranyai, Tamás; Boengler K; Rohrbach S; Li L; Schluter KD; Schreckenberg R; Radovits, Tamás; Oláh, Attila; Mátyás, Csaba; Lux, Árpád; Al-Khrasani, Mahmoud; Komlódi, Tímea; Bukosza, Éva Nóra; Máthé, Domokos; Deres, László; Bartekova M; Rajtik T; Adameova A; Szigeti, Krisztián; Hamar, Péter; Helyes, Zsuzsanna; Tretter, László; Pacher, Pál; Merkely, Béla Péter; Giricz, Zoltán; Schulz R; Ferdinandy, Péter (2016)
    Although incidence and prevalence of prediabetes are increasing, little is known on its cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac function and to characterize parameters ...
  • Drug-induced mitochondrial dysfunction and cardiotoxicity 
    Varga, Zoltán; Ferdinandy, Péter; Liaudet L; Pacher, Pál (2015)
    Mitochondria has essential role in myocardial tissue homeostasis, thus deterioration in mitochondrial function eventually leads to cardiomyocyte and endothelial cell death and consequent cardiovascular dysfunction. Several ...
  • Endothelial dysfunction and angiogenesis impairment in the ageing vasculature 
    Ungvári, Zoltán István; Tarantini, Stefano; Kiss, Tamás; Wren, JD; Giles, CB; Griffin, CT; Murfee, WL; Pacher, Pál; Csiszar, Anna (2018)
    Ageing is the main risk factor for the development of cardiovascular diseases. A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of ...
  • Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy 
    Varga, Zoltán; Giricz, Zoltán; Liaudet L; Hasko G; Ferdinandy, Péter; Pacher, Pál (2015)
    Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic cardiovascular dysfunction also underscores the development of diabetic retinopathy, nephropathy and neuropathy. Despite the ...
  • Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain 
    Szalay, Csaba Imre; Erdélyi, Katalin; Kökény, Gábor; Lajtar E; Godo M; Revesz C; Kaucsár, Tamás; Kiss, Norbert; Sárközy, Márta; Csont, Tamás Bálint; Krenács, Tibor; Szénási, Gábor; Pacher, Pál; Hamar, Péter (2015)
    Chronic renal fibrosis is the final common pathway of end stage renal disease caused by glomerular or tubular pathologies. Genetic background has a strong influence on the progression of chronic renal fibrosis. We recently ...
  • Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation 
    Iring, András; Ruisanchez, Éva; Leszl-Ishiguro, Miriam; Horváth, Béla András; Benkő, Rita; Lacza, Zsombor; Járai, Zoltán; Sándor, Péter; Di Marzo V; Pacher, Pál; Benyó, Zoltán (2013)
    BACKGROUND: Endocannabinoids are among the most intensively studied lipid mediators of cardiovascular functions. In the present study the effects of decreased and increased activity of the endocannabinoid system (achieved ...