tallózása szerző szerint "Tóvári, József"

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Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications

Döme, Balázs; Hendrix, Mary JC; Paku, Sándor; Tóvári, József; Tímár, József (2007)

Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor growth is highly dependent on the supply of oxygen, nutrients, and host-derived regulators. It is now established that tumor vasculature ...
Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing

Vas, Virág; Háhner, Tamás; Kudlik, Gyöngyi; Ernszt, Dávid; Kvell, Krisztián; Kuti, Dániel; Kovács, Krisztina J; Tóvári, József; Trexler, Mária; Merő, Balázs László; Szeder, Bálint; Koprivanacz, Kitti; Buday, László (2019)

Obesity and adipocyte malfunction are related to and arise as consequences of disturbances in signaling pathways. Tyrosine kinase substrate with four Src homology 3 domains (Tks4) is a scaffold protein that establishes a ...
A New Mechanism for Pillar Formation during Tumor-Induced Intussusceptive Angiogenesis

Paku, Sándor; Dezső, Katalin; Bugyik, Edina; Tóvári, József; Tímár, József; Nagy, Péter; Laszlo, Viktoria; Klepetko W; Döme, Balázs (2011)

One of the hallmarks of intussusceptive angiogenesis is the development of intraluminal connective tissue pillars. The exact mechanism of pillar formation has not yet been elucidated. By using electron and confocal microscopy, ...
Antimigratory and antimetastatic effect of heparin-derived 4-18 unit oligosaccharides in a preclinical human melanoma metastasis model

Kenessey, István; Simon E; Futosi, Krisztina; Bereczky, Bíborka; Kiss, Andrea; Erdődi, Ferenc; Gallagher JT; Tímár, József; Tóvári, József (2009)

Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments containing 4 to 22 monomers on human melanoma cell proliferation, ...
Apelin expression in human non-small cell lung cancer: Role in angiogenesis and prognosis

Berta, Judit; Kenessey, István; Dobos J; Tóvári, József; Klepetko W; Ankersmit HJ; Hegedűs, Balázs; Rényi-Vámos, Ferenc István; Varga, János; Lorincz Zs; Paku, Sándor; Ostoros, Gyula; Rózsás, Anita; Tímár, József; Döme, Balázs (2010)
Apelin promotes lymphangiogenesis and lymph node metastasis

Berta, Judit; Hoda MA; Laszlo, Viktoria; Rozsas A; Garay, Tamás; Torok S; Grusch M; Berger W; Paku, Sándor; Rényi-Vámos, Ferenc István; Masri B; Tóvári, József; Groger M; Klepetko W; Hegedűs, Balázs; Döme, Balázs (2014)

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been ...
Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion

Tímár, József; Trikha M; Szekeres K; Bazaz R; Tóvári, József; Silletti S; Raz A; Honn KV (1996)
Boyden chamber-based method for characterizing the distribution of adhesions and cytoskeletal structure in HT1080 fibrosarcoma cells

Tóvári, József; Futosi, Krisztina; Bartal A; Tátrai, Enikő; Gacs A; Kenessey, István; Paku, Sándor (2014)
Cell type-dependent HIF1 alpha-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells

Tatrai E; Bartal A; Gacs A; Paku S; Kenessey, István; Garay, Tamás; Hegedűs, Balázs; Molnár, Eszter; Cserepes MT; Hegedus Z; Kucsma, Nóra; Szakács, Gergely; Tóvári, József (2017)

Tumor hypoxia promotes neoangiogenesis and contributes to the radio- and chemotherapy resistant and aggressive phenotype of cancer cells. However, the migratory response of tumor cells and the role of small GTPases regulating ...
Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic haematopoietic cells in cancer: From biology to therapy

Döme, Balázs; Tímár, József; Ladányi, Andrea; Paku, Sándor; Rényi-Vámos, Ferenc István; Klepetko, Walter; Lang, György; Döme, Péter; Bogos, Krisztina; Tóvári, József (2009)

Vascularization, a hallmark of tumorigenesis, is classically thought to occur exclusively through angiogenesis (i.e. endothelial sprouting). However, there is a growing body of evidence that endothelial progenitor cells ...
Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas

Szabó, Balázs; Nelhűbel GA; Kárpáti A; Kenessey, István; Jóri B; Székely Cs; Peták, István; Lotz, Gábor; Hegedűs, Zita; Hegedűs, Balázs; Füle T; Döme, Balázs; Tímár, József; Tóvári, József (2011)
Development of arterial blood supply in experimental liver metastases

Dezső, Katalin; Bugyik, Edina; Papp, Veronika; Laszlo, Viktoria; Döme, Balázs; Tóvári, József; Tímár, József; Nagy, Péter; Paku, Sándor (2009)
Ectopic alpha IIb beta 3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells

Rásó, Erzsébet; Tóvári, József; Tóth, Krisztina; Paku, Sándor; Trikha, Mohit; Kenneth, V. Honn; Tímár, József (2001)

Megakaryocytic genes such as alpha IIb beta3 can be expressed by malignant cells as part of the disturbances in their gene regulation. However, the function of the gene product greatly depends on the interaction of ...
Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma

Rozsas A; Berta, Judit; Rojko L; Horvath LZ; Keszthelyi M; Kenessey, István; Laszlo, Viktoria; Berger W; Grusch M; Hoda MA; Torok S; Klepetko W; Rényi-Vámos, Ferenc István; Hegedűs, Balázs; Döme, Balázs; Tóvári, József (2013)

Recombinant human erythropoietins (rHuEPOs) are used to treat cancer-related anemia. Recent preclinical studies and clinical trials, however, have raised concerns about the potential tumor-promoting effects of these drugs. ...
Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy

Schelch K; Hoda MA; Klikovits T; Munzker J; Ghanim B; Wagner C; Garay, Tamás; Laszlo, Viktoria; Setinek U; Döme, Balázs; Filipits M; Pirker C; Heffeter P; Selzer E; Tóvári, József; Török, Szilvia; Kenessey, István; Holzmann K; Grasl-Kraupp B; Marian B; Klepetko W; Berger W; Hegedűs, Balázs; Grusch M (2014)

RATIONALE: Malignant pleural mesothelioma is an aggressive malignancy characterized by frequent resistance to chemo- and radiotherapy, poor outcome, and limited therapeutic options. Fibroblast growth factors (FGFs) and ...
Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

Szebényi, Kornélia; Füredi, András; Kolacsek, Orsolya; Pergel E; Bősze, Zsuzsanna; Bender B; Vajdovich, Péter; Tóvári, József; Homolya, László; Szakács, Gergely; Héja, László; Enyedi, Ágnes; Sarkadi, Balázs; Apáti, Ágota; Orbán, Tamás I. (2015)

In drug discovery, prediction of selectivity and toxicity require the evaluation of cellular calcium homeostasis. The rat is a preferred laboratory animal for pharmacology and toxicology studies, while currently no ...
High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer

Bogos, Krisztina; Rényi-Vámos, Ferenc István; Dobos, Judit; Kenessey, István; Tóvári, József; Tímár, József; Strausz, János; Ostoros, Gyula; Klepetko Walter; Ankersmit Hendrik Jan; Lang, György; Hoda Mir AliReza; Nierlich Patrick; Döme, Balázs (2009)
KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

Kenessey, István; Koi K; Horvath O; Cserepes M; Molnar D; Izsak V; Dobos, Judit; Hegedűs, Balázs; Tóvári, József; Tímár, József (2017)

BACKGROUND: In non-small cell lung cancer (NSCLC) KRAS-mutant status is a negative prognostic and predictive factor. Nitrogen-containing bisphosphonates inhibit prenylation of small G-proteins (e.g. Ras, Rac, Rho) and thus ...
Lack of Angiogenesis in Experimental Brain Metastases

Bugyik, Edina; Dezső, Katalin; Reiniger, Lilla; Laszlo, Viktoria; Tóvári, József; Tímár, József; Nagy, Péter; Klepetko W; Döme, Balázs; Paku, Sándor (2011)

Angiogenesis is believed to be essential for the growth of metastatic tumors in the brain. We analyzed the vascularization of tumors formed by 4 epithelial cell lines (C38, ZR75, HT25, and H1650) and a fibrosarcoma (HT1080) ...
Localization of sunitinib, its metabolites and its target receptors in tumour bearing mice: a MALDI mass spectrometry imaging study

Török, Szilvia; Vegvari A; Rezeli M; Fehniger TE; Tóvári, József; Paku, Sándor; Laszlo, Viktoria; Hegedűs, Balázs; Rózsás, Anita; Döme, Balázs; Marko-Varga G (2015)

BACKGROUND AND PURPOSE: The clinical impact of antiangiogenic agents remains controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue. EXPERIMENTAL APPROACH: In our study, ...

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