Current concepts in the genetic diagnostics of rheumatoid arthritis.

dc.contributor.author	Nagy Zsolt
dc.contributor.author	Csanád Mónika
dc.contributor.author	Tóth Katalin
dc.contributor.author	Börzsönyi Balázs
dc.contributor.author	Demendi Csaba
dc.contributor.author	Rigó János
dc.contributor.author	Joó József Gábor
dc.date.accessioned	2015-01-30T08:33:21Z
dc.date.available	2015-01-30T08:33:21Z
dc.date.issued	2010
dc.identifier.citation	pagination=603-618;journalVolume=10;journalIssueNumber=5;journalTitle=EXPERT REVIEW OF MOLECULAR DIAGNOSTICS;	hu
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/1200
dc.identifier.uri	doi:10.1586/ERM.10.36
dc.description.abstract	Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease of unknown etiology. HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease. Currently, several immunopathogenetic models of other genes (CTLA4, MIF, PADI4 and SLC22A4) are under debate. The clinical influence of some of the gene polymorphisms associated with RA and the principles of pharmacogenetics applied to different therapies, such as classical disease-modifying anti-rheumatic drugs and new biological agents. Pharmacogenetics is a rapidly advancing area of research that holds the promise that therapies will soon be tailored to an individual patient's genetic profile.	hu
dc.relation.ispartof	urn:issn:1473-7159
dc.title	Current concepts in the genetic diagnostics of rheumatoid arthritis.	hu
dc.type	Journal Article	hu
dc.date.updated	2015-01-22T22:50:03Z
dc.language.rfc3066	en	hu
dc.identifier.mtmt	1458825
dc.identifier.wos	000280172700011
dc.identifier.pubmed	20629510
dc.contributor.department	SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.department	SE/AOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution	Semmelweis Egyetem