Egyszerű nézet

dc.contributor.author Cservenák, Melinda
dc.contributor.author Bodnár, Ibolya
dc.contributor.author Usdin TB
dc.contributor.author Palkovits, Miklós
dc.contributor.author Nagy, M. György
dc.contributor.author Dobolyi, Árpád
dc.date.accessioned 2016-07-21T08:34:55Z
dc.date.available 2016-07-21T08:34:55Z
dc.date.issued 2010
dc.identifier.citation pagination=5830-5840; journalVolume=151; journalIssueNumber=12; journalTitle=ENDOCRINOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1291
dc.identifier.uri doi:10.1210/en.2010-0767
dc.description.abstract Tuberoinfundibular peptide of 39 residues (TIP39) and the PTH-2 receptor (PTH2R) constitute a peptide-receptor neuromodulator system. Based on the abundance of TIP39 fibers and axonal terminals as well as PTH2R-containing neurons and their processes in the hypothalamic para- and periventricular and arcuate nuclei TIP39 has been suggested to play a role in neuroendocrine regulation. We showed previously that TIP39 expression decreased dramatically by adulthood. In the present study, using in situ hybridization histochemistry, real-time RT- PCR, and immunohistochemistry, we found that TIP39 mRNA and peptide expression levels are markedly elevated in the posterior intralaminar complex of the thalamus (PIL) of lactating dams, one of the three locations of TIP39-containing cell bodies in the brain. In addition, in mother rats, these TIP39 neurons showed Fos expression in response to pup exposure. Transection of TIP39 fibers originating in the PIL resulted in an ipsilateral disappearance of TIP39 immunoreactivity throughout the mediobasal hypothalamus of mother rats, suggesting that TIP39 fibers there arise from the PIL. To elucidate the function of TIP39 activation in dams, mothers separated from their pups for 4 h on postpartum d 9 received injection of a PTH2R antagonist into the lateral ventricle 5 min before returning the pups. Blood samples were taken seven times during the experimental period through jugular cannulae. The PTH2R antagonist administered in two different concentrations markedly inhibited suckling-induced elevation of plasma prolactin levels in a dose-dependent manner. These results suggest that TIP39 neurons in the PIL may regulate suckling-induced prolactin release in rat dams.
dc.relation.ispartof urn:issn:0013-7227
dc.title Tuberoinfundibular Peptide of 39 Residues Is Activated during Lactation and Participates in the Suckling-Induced Prolactin Release in Rat.
dc.type Journal Article
dc.date.updated 2015-02-02T12:22:34Z
dc.language.rfc3066 en
dc.identifier.mtmt 1387233
dc.identifier.wos 000284489800027
dc.identifier.pubmed 20861230
dc.contributor.department SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet
dc.contributor.department SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet
dc.contributor.institution Semmelweis Egyetem


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