dc.contributor.author |
Szijártó István András |
|
dc.contributor.author |
Molnár Gergő Attila |
|
dc.contributor.author |
Mikolás Esztella Zsóka |
|
dc.contributor.author |
Fisi Viktória |
|
dc.contributor.author |
Cseh Judit |
|
dc.contributor.author |
Laczy Boglárka |
|
dc.contributor.author |
Kovács Tibor |
|
dc.contributor.author |
Böddi Katalin |
|
dc.contributor.author |
Takátsy Anikó |
|
dc.contributor.author |
Maik Gollasch |
|
dc.contributor.author |
Koller Ákos |
|
dc.contributor.author |
Wittmann István |
|
dc.date.accessioned |
2015-02-04T08:29:14Z |
|
dc.date.available |
2015-02-04T08:29:14Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
pagination=749-752;journalVolume=46;journalIssueNumber=11;journalTitle=HORMONE AND METABOLIC RESEARCH; |
hu |
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1317 |
|
dc.identifier.uri |
doi:10.1055/s-0034-1387701 |
|
dc.description.abstract |
Previous studies have shown that in diabetes mellitus, insulin-induced relaxation of arteries is impaired and the level of ortho-tyrosine (o-Tyr), an oxidized amino acid is increased. Thus, we hypothesized that elevated vascular level of o-Tyr contributes to the impairment of insulin-induced vascular relaxation. Rats were fed with o-Tyr for 4 weeks. Insulin-induced vasomotor responses of isolated femoral artery were studied using wire myography. Vascular o-Tyr content was measured by HPLC, whereas immunoblot analyses were preformed to detect eNOS phosphorylation. Sustained oral supplementation of rats with o-Tyr increased the content of o-Tyr in the arterial wall and significantly reduced the relaxations to insulin. Sustained supplementation of cultured endothelial cells with o-Tyr increased the incorporation of o-Tyr and mitigated eNOS Ser (1 177) phosphorylation to insulin. Increasing arterial wall o-Tyr level attenuates insulin-induced relaxation - at least in part - by decreasing eNOS activation. Elevated level of o-Tyr could be an underlying mechanism for vasomotor dysfunction in diabetes mellitus. |
hu |
dc.relation.ispartof |
urn:issn:0018-5043 |
|
dc.title |
Elevated Vascular Level of ortho-Tyrosine Contributes to the Impairment of Insulin-Induced Arterial Relaxation. |
hu |
dc.type |
Journal Article |
hu |
dc.date.updated |
2015-02-04T08:26:49Z |
|
dc.language.rfc3066 |
en |
hu |
dc.identifier.mtmt |
2743437 |
|
dc.identifier.wos |
000343583200001 |
|
dc.identifier.pubmed |
25208272 |
|
dc.contributor.department |
PTE/Szentágothai János Kutatóközpont |
|
dc.contributor.department |
SE/AOK/I/Kórélettani Intézet |
|
dc.contributor.institution |
Pécsi Tudományegyetem |
|
dc.contributor.institution |
Semmelweis Egyetem |
|