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dc.contributor.author Jakus, Zoltán
dc.contributor.author Gleghorn JP
dc.contributor.author Enis DR
dc.contributor.author Sen A
dc.contributor.author Chia S
dc.contributor.author Liu X
dc.contributor.author Rawnsley DR
dc.contributor.author Yang Y
dc.contributor.author Hess PR
dc.contributor.author Zou Z
dc.contributor.author Yang J
dc.contributor.author Guttentag SH
dc.contributor.author Nelson CM
dc.contributor.author Kahn ML
dc.date.accessioned 2016-09-09T08:41:00Z
dc.date.available 2016-09-09T08:41:00Z
dc.date.issued 2014
dc.identifier 84899732109
dc.identifier.citation pagination=815-826; journalVolume=211; journalIssueNumber=5; journalTitle=JOURNAL OF EXPERIMENTAL MEDICINE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1320
dc.identifier.uri doi:10.1084/jem.20132308
dc.description.abstract Mammals must inflate their lungs and breathe within minutes of birth to survive. A key regulator of neonatal lung inflation is pulmonary surfactant, a lipoprotein complex which increases lung compliance by reducing alveolar surface tension (Morgan, 1971). Whether other developmental processes also alter lung mechanics in preparation for birth is unknown. We identify prenatal lymphatic function as an unexpected requirement for neonatal lung inflation and respiration. Mice lacking lymphatic vessels, due either to loss of the lymphangiogenic factor CCBE1 or VEGFR3 function, appear cyanotic and die shortly after birth due to failure of lung inflation. Failure of lung inflation is not due to reduced surfactant levels or altered development of the lung but is associated with an elevated wet/dry ratio consistent with edema. Embryonic studies reveal active lymphatic function in the late gestation lung, and significantly reduced total lung compliance in late gestation embryos that lack lymphatics. These findings reveal that lymphatic vascular function plays a previously unrecognized mechanical role in the developing lung that prepares it for inflation at birth. They explain respiratory failure in infants with congenital pulmonary lymphangiectasia, and suggest that inadequate late gestation lymphatic function may also contribute to respiratory failure in premature infants.
dc.relation.ispartof urn:issn:0022-1007
dc.title Lymphatic function is required prenatally for lung inflation at birth
dc.type Journal Article
dc.date.updated 2015-02-04T10:22:21Z
dc.language.rfc3066 en
dc.identifier.mtmt 2575274
dc.identifier.pubmed 24733830
dc.mtmt.swordnote FELTÖLTŐ: Sonnevend Kinga - sonnevend.kinga@med.semmelweis-univ.hu


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