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dc.contributor.author Kovács, Miklós
dc.contributor.author Németh, Tamás
dc.contributor.author Jakus, Zoltán
dc.contributor.author Sitaru C
dc.contributor.author Simon, Edina
dc.contributor.author Futosi, Krisztina
dc.contributor.author Botz, Bálint
dc.contributor.author Helyes, Zsuzsanna
dc.contributor.author Lowell CA
dc.contributor.author Mócsai, Attila
dc.date.accessioned 2016-08-10T18:44:57Z
dc.date.available 2016-08-10T18:44:57Z
dc.date.issued 2014
dc.identifier 84907211081
dc.identifier.citation pagination=1993-2011; journalVolume=211; journalIssueNumber=10; journalTitle=JOURNAL OF EXPERIMENTAL MEDICINE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/1354
dc.identifier.uri doi:10.1084/jem.20132496
dc.description.abstract Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly understood. We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoietic compartment were completely protected from autoantibody-induced arthritis and skin blistering disease, as well as from the reverse passive Arthus reaction, with functional overlap between the three kinases. Though the overall phenotype resembled the leukocyte recruitment defect observed in β2 integrin-deficient (CD18(-/-)) mice, Hck(-/-)Fgr(-/-)Lyn(-/-) neutrophils and monocytes/macrophages had no cell-autonomous in vivo or in vitro migration defect. Instead, Src family kinases were required for the generation of the inflammatory environment in vivo and for the release of proinflammatory mediators from neutrophils and macrophages in vitro, likely due to their role in Fcγ receptor signal transduction. Our results suggest that infiltrating myeloid cells release proinflammatory chemokine, cytokine, and lipid mediators that attract further neutrophils and monocytes from the circulation in a CD18-dependent manner. Src family kinases are required for the generation of the inflammatory environment but not for the intrinsic migratory ability of myeloid cells.
dc.relation.ispartof urn:issn:0022-1007
dc.title The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
dc.type Journal Article
dc.date.updated 2015-02-05T14:18:46Z
dc.language.rfc3066 en
dc.identifier.mtmt 2735476
dc.identifier.wos 000342744800009
dc.identifier.pubmed 25225462
dc.contributor.department PTE/Szentágothai János Kutatóközpont
dc.contributor.department SE/AOK/I/Élettani Intézet
dc.contributor.department SE/AOK/I/ÉI/MTA-SE Lendület Nyirokélettani Kutatócsoport
dc.contributor.department SE/AOK/I/ÉI/MTA-SE Lendület Gyulladásélettani Kutatócsoport
dc.contributor.institution Pécsi Tudományegyetem
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote FELTÖLTŐ: Sonnevend Kinga - sonnevend.kinga@med.semmelweis-univ.hu


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