dc.contributor.author |
Kiss, József |
|
dc.contributor.author |
Csaba, Zsolt |
|
dc.contributor.author |
Csáki, Ágnes |
|
dc.contributor.author |
Halász, Béla |
|
dc.date.accessioned |
2017-06-22T07:18:03Z |
|
dc.date.available |
2017-06-22T07:18:03Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
pagination=595-602;
journalVolume=226;
journalIssueNumber=4;
journalTitle=EXPERIMENTAL BRAIN RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1539 |
|
dc.identifier.uri |
doi:10.1007/s00221-013-3474-8 |
|
dc.description.abstract |
By means of double-label immunocytochemistry, authors studied the presence of estrogen receptor alpha (ER-alpha) protein in vesicular glutamate transporter 2 (VGluT2) protein-immunoreactive neurons in the female rat hypothalamus and amygdala. They examined colocalization of the 2 immunoreactive proteins in structures in which they found a significant overlap in the localization of the distribution of ER-alpha- and VGluT2-immunopositive nerve cells, namely in the medial preoptic area, the ventral subdivision of the ventromedial hypothalamic nucleus, and the medial amygdaloid nucleus. In the medial preoptic area, only 2.74 % of ER-alpha-immunoreactive neurons were VGluT2 positive, and conversely, 5 % of VGluT2-immunoreactive neurons contained ER-alpha immunofluorescent labeling. Highest degree of colocalization was detected in the ventral subdivision of the ventromedial hypothalamic nucleus, where 22.81 % of the ER-alpha-immunopositive neurons were VGluT2 immunoreactive and 37.14 % of the VGluT2-immunolabeled neurons contained ER-alpha-positive nucleus. In the medial amygdaloid nucleus, 15.38 % of the ER-alpha and 18.1 % of the VGluT2-immunoreactive neurons were double labeled. The colocalizations suggest that glutamatergic (VGluT2 protein immunoreactive) neurons are involved in the mediation of the action of estrogen on the rat brain. |
|
dc.relation.ispartof |
urn:issn:0014-4819 |
|
dc.title |
Demonstration of estrogen receptor alpha protein in glutamatergic (vesicular glutamate transporter 2 immunoreactive) neurons of the female rat hypothalamus and amygdala using double-label immunocytochemistry. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-03-10T12:03:48Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2333396 |
|
dc.identifier.pubmed |
23543101 |
|
dc.contributor.department |
SE/AOK/I/Humánmorfológiai és Fejlődésbiológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|