dc.contributor.author |
Huleatt P B |
|
dc.contributor.author |
Khoo M L |
|
dc.contributor.author |
Chua Y Y |
|
dc.contributor.author |
Tan T W |
|
dc.contributor.author |
Liew R S |
|
dc.contributor.author |
Balogh, Balázs |
|
dc.contributor.author |
Deme, Ruth |
|
dc.contributor.author |
Gölöncsér Flóra |
|
dc.contributor.author |
Magyar, Kálmán |
|
dc.contributor.author |
Sheela D P |
|
dc.contributor.author |
Ho H K |
|
dc.contributor.author |
Sperlágh, Beáta |
|
dc.contributor.author |
Mátyus, Péter |
|
dc.contributor.author |
Chai C L L |
|
dc.date.accessioned |
2015-03-28T18:06:51Z |
|
dc.date.available |
2015-03-28T18:06:51Z |
|
dc.date.issued |
2015 |
|
dc.identifier |
84922765736 |
|
dc.identifier.citation |
pagination=1400-1419;
journalVolume=58;
journalIssueNumber=3;
journalTitle=JOURNAL OF MEDICINAL CHEMISTRY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1640 |
|
dc.identifier.uri |
doi:10.1021/jm501722s |
|
dc.description.abstract |
To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease. |
|
dc.relation.ispartof |
urn:issn:0022-2623 |
|
dc.title |
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson’s disease |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-03-28T18:06:15Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2827988 |
|
dc.identifier.pubmed |
25627172 |
|
dc.contributor.department |
SE/GYTK/Szerves Vegytani Intézet |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|