Show simple item record Monica F, Lirussi F, Pregun, István Vasile F, Fabris L, 2015-04-28T16:37:57Z 2015-04-28T16:37:57Z 2006
dc.identifier.citation pagination=336-340; journalVolume=38; journalIssueNumber=5; journalTitle=DIGESTIVE AND LIVER DISEASE;
dc.identifier.uri doi:10.1016/j.dld.2005.12.014
dc.description.abstract BACKGROUND: The natural history of hepatitis C virus infection in the elderly is poorly known. OBJECTIVE: To assess the mortality rate, the progression of liver disease, the hepatitis C virus carrier state and the co-morbidity in a cohort of 35 out of 1,063 anti-hepatitis C virus positive elderly people prospectively followed-up from 1992 to 2002. METHODS: Liver function tests, hepatitis C virus-RNA analysis, hepatitis C virus genotyping and abdominal ultrasonography were assessed at the beginning of the study, and then, liver function tests and ultrasonography were performed annually during the first 5 years of the follow-up. At the end of the 10-year period, causes of death were recorded, while surviving patients underwent again medical examination, liver function tests and abdominal ultrasonography. RESULTS: Out of 35 patients with a 10-year follow-up, 12 patients died: only 2 (5.7%) from liver-related disease (hepatocellular carcinoma and liver failure), whilst 10 (28.5%) from extrahepatic causes. Out of the two patients dying from liver-related causes, one was hepatitis C virus-RNA positive and one hepatitis C virus-RNA negative. Among the 23 living patients, 13 were hepatitis C virus-RNA positive (56.5%), the majority being infected with genotype 2 (69%); of them, 6 (46.1%) had persistently normal alanine aminotransferase levels. None of the hepatitis C virus-RNA positive individuals had excessive alcohol intake. CONCLUSION: Despite the presumably long duration of infection in our cohort, the liver-related mortality was five-fold lower than that from extrahepatic causes (five-fold higher). Lack of hepatic co-morbidity factors, such as alcohol consumption, seems to be relevant for the limited severity of liver disease.
dc.relation.ispartof urn:issn:1590-8658
dc.title Hepatitis C virus infection in a resident elderly population: a 10-year follow-up study.
dc.type Journal Article 2015-04-28T16:37:13Z
dc.language.rfc3066 en
dc.identifier.mtmt 1722781
dc.identifier.wos 000238080500011
dc.identifier.pubmed 16627021
dc.mtmt.swordnote : Gastroenterology and the Italian Association for the Study of the Liver

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