dc.contributor.author |
Firneisz, Gábor |
|
dc.date.accessioned |
2015-06-09T13:31:38Z |
|
dc.date.available |
2015-06-09T13:31:38Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
pagination=9072-9089;
journalVolume=20;
journalIssueNumber=27;
journalTitle=WORLD JOURNAL OF GASTROENTEROLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1773 |
|
dc.identifier.uri |
doi:10.3748/wjg.v20.i27.9072 |
|
dc.description.abstract |
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by hepatocyte ballooning and lobular inflammation +/- fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. NAFL increasingly affects children (paediatric prevalence is 4.2%-9.6%). Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity, metabolic syndrome and NAFLD are particularly closely related. Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of gestational diabetes mellitus. The accumulation of triacylglycerols in hepatocytes is predominantly derived from the plasma nonesterified fatty acid pool supplied largely by the adipose tissue. A few NAFLD susceptibility gene variants are associated with progressive liver disease, IR, T2DM and a higher risk for hepatocellular carcinoma. Although not approved, pharmacological approaches might be considered in NASH patients. |
|
dc.relation.ispartof |
urn:issn:1007-9327 |
|
dc.title |
Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age? |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-05-06T08:38:53Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2741750 |
|
dc.identifier.pubmed |
25083080 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|