dc.contributor.author |
Balog B |
|
dc.contributor.author |
Tőke, Judit |
|
dc.contributor.author |
Róna, Kálmán |
|
dc.contributor.author |
Szücs, Nikolette |
|
dc.contributor.author |
Igaz, Péter |
|
dc.contributor.author |
Pusztai, Péter |
|
dc.contributor.author |
Sármán, Beatrix |
|
dc.contributor.author |
Gláz, Edit |
|
dc.contributor.author |
Kiss, Róbert |
|
dc.contributor.author |
Patócs, Attila Balázs |
|
dc.contributor.author |
Rácz, Károly |
|
dc.contributor.author |
Tóth, Miklós |
|
dc.date.accessioned |
2015-08-08T13:43:28Z |
|
dc.date.available |
2015-08-08T13:43:28Z |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
pagination=626-635;
journalVolume=156;
journalIssueNumber=16;
journalTitle=ORVOSI HETILAP; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/1941 |
|
dc.identifier.uri |
doi:10.1556/OH.2015.30127 |
|
dc.description.abstract |
INTRODUCTION: Laboratory diagnosis of pheochromocytoma-paraganglioma syndrome has been markedly improved during the past two decades. AIM: Retrospective assessment of diagnostic utility of urinary catecholamines and their metabolites as well as serum chromogranin A in 155 patients diagnosed at the 2nd Department of Medicine, Semmelweis University. METHOD: Urinary catecholamines and metabolites were measured using high-performance liquid chromatography with electrochemical detection in 155 patients with pheochromocytoma-paraganglioma (of whom 28.4% had hereditary background) and in 170 non-pheochromocytoma patients used as controls. Serum chromogranin A was measured by immunoradiometry. RESULTS: Sensitivity (93.2%) and specificity (87.0%) of urinary fractionated metanephrines were higher than those of urinary catecholamines (90.9% vs. 85.7%, respectively) and serum chromogranin A (88.7% and 77.5%, respectively). Urinary normetanephrine and serum chromogranin A correlated positively with tumor size (r = 0.552, p<0.0001 and r = 0.618, p<0.0001, respectively). CONCLUSIONS: These data confirm the diagnostic utility of urinary catecholamines and their metabolites. Urinary normetanephrine and serum chromogranin A may help to estimate tumour mass and probably tumour progression. Orv. Hetil., 2015, 156(16), 626-635. |
|
dc.relation.ispartof |
urn:issn:0030-6002 |
|
dc.title |
A laboratóriumi diagnosztika eredményei az elmúlt 20 évben kórismézett 155 phaeochromocytoma/paraganglioma szindrómás beteg adatainak elemzése alapján. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-07-04T13:22:16Z |
|
dc.language.rfc3066 |
hu |
|
dc.identifier.mtmt |
2880305 |
|
dc.identifier.wos |
WOS:000352564700002 |
|
dc.identifier.pubmed |
25864138 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/I/Igazságügyi és Biztosítás-orvostani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|