Tumor cell expression of Heat Shock Protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts Survival in Small Cell Lung Cancer (SCLC) patients

dc.contributor.author	Szondy, Klára
dc.contributor.author	Rusai, Krisztina
dc.contributor.author	Szabó, Attila
dc.contributor.author	Nagy A
dc.contributor.author	Gál, Krisztina
dc.contributor.author	Fekete, Andrea
dc.contributor.author	Kováts, Zsuzsanna
dc.contributor.author	Losonczy, György
dc.contributor.author	Lukácsovits, József
dc.contributor.author	Müller, Veronika
dc.date.accessioned	2016-05-10T13:32:20Z
dc.date.available	2016-05-10T13:32:20Z
dc.date.issued	2012
dc.identifier	84860121190
dc.identifier.citation	pagination=317-322; journalVolume=30; journalIssueNumber=4; journalTitle=CANCER INVESTIGATION;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/2262
dc.identifier.uri	doi:10.3109/07357907.2012.657815
dc.description.abstract	The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC cells was significantly decreased in GG as compared to cells of AA or AG genotype patients, and was associated with significantly shorter survival in GG patients as compared to carriers of the A allele. Decreased HSP72 expression of SCLC cells associated with HSP72 GG genotype is a negative prognostic factor for survival in SCLC patients. © 2012 Informa Healthcare USA, Inc.
dc.relation.ispartof	urn:issn:0735-7907
dc.title	Tumor cell expression of Heat Shock Protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts Survival in Small Cell Lung Cancer (SCLC) patients
dc.type	Journal Article
dc.date.updated	2015-11-03T11:37:43Z
dc.language.rfc3066	en
dc.identifier.mtmt	1953782
dc.identifier.wos	000303249200009
dc.identifier.pubmed	22468780
dc.contributor.department	SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department	SE/AOK/K/Pulmonológiai Klinika
dc.contributor.institution	Semmelweis Egyetem