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dc.contributor.author Tárnoki, Ádám Domonkos
dc.contributor.author Tárnoki, Dávid László
dc.contributor.author Stazi M A,
dc.contributor.author Medda E,
dc.contributor.author Cotichini R,
dc.contributor.author Kiss, Róbert Gábor
dc.contributor.author Karlinger, Kinga
dc.contributor.author Bérczi, Viktor
dc.contributor.author Garami, Zsolt
dc.date.accessioned 2017-01-12T13:27:52Z
dc.date.available 2017-01-12T13:27:52Z
dc.date.issued 2011
dc.identifier 79957937421
dc.identifier.citation pagination=61-71; journalVolume=35; journalIssueNumber=2; journalTitle=JOURNAL FOR VASCULAR ULTRASOUND;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2399
dc.description.abstract Introduction.- Atherosclerosis is an inflammatory process in which the artery wall thickens as a result of plaque deposition, but this process may be preceded by increased arterial stiffness. We sought to evaluate the influence of genetics and shared and unshared environmental components on the onset of atherosclerosis. Methods.- A total of 135 monozygotic (MZ) and 70 dizygotic (DZ) twin pairs (mean age 49 ± 16 years) underwent carotid intima media thickness (IMT; carotid analyzer) and arterial stiffness (augmentation index on brachial artery [Aixbra] pulse wave velocity on aorta [PWV ao]; TensioMed Arteriograph) measurements. Results.- Age-adjusted intraclass correlations were greater in MZ than in DZ pairs for proximal right common carotid artery (CCA; MZ = 0.19, DZ = 0.06), proximal and distal left CCA (MZ = 0.27, DZ = 0.06; MZ = 0.27, DZ = 0.13, respectively), and proximal left internal carotid artery (ICA; MZ = 0.39, DZ = -0.54), suggesting a moderate genetic effect. Heritability was estimated to be 18% (95% confidence interval [CI] = 3-33) for proximal right CCA, 26% and 27% for proximal and distal left CCA, respectively, and 38% (95% CI = 26-49) for proximal left ICA. Regarding distal right CCA and proximal right ICA, no genetic effects were detected. Age-adjusted intraclass correlation of Aixbra and PWVao were 0.65 (95% CI = 0.55-0.72) and 0.46 (95% CI = 0.33-0.57) in MZ, 0.42 (95% CI = 0.24-0.57) and 0.28 (95% CI = 0.08-0.47) in DZ pairs; heritability 45% (95% CI = 12-71%) and 42% (95% CI = 2-57%) adjusted by age, respectively. Conclusions.- The investigated parameters appeared to be only moderately influenced by genetic factors. Environmental factors of relevance for these measures appeared not to be shared within family but related to individual experience (e.g., smoking habits, diet, and physical activity). Atherosclerosis detection at an early stage is necessary for treatment to prevent serious complications such as stroke and heart attack.
dc.relation.ispartof urn:issn:1544-3167
dc.title Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009
dc.type Journal Article
dc.date.updated 2015-11-20T10:02:33Z
dc.language.rfc3066 en
dc.identifier.mtmt 1747711
dc.contributor.department SE/AOK/K/Radiológiai és Onkoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem


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