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dc.contributor.author Müller, Katalin Eszter
dc.contributor.author Lakatos, Péter László
dc.contributor.author Arató, András
dc.contributor.author Kovács JB
dc.contributor.author Herczegné Várkonyi, Ágnes
dc.contributor.author Szűcs D
dc.contributor.author Szakos E
dc.contributor.author Sólyom E
dc.contributor.author Kovács M
dc.contributor.author Polgár M
dc.contributor.author Nemes, Éva
dc.contributor.author Guthy I
dc.contributor.author Tokodi I
dc.contributor.author Tóth, Gergely Péter
dc.contributor.author Horváth A
dc.contributor.author Tárnok, András
dc.contributor.author Csoszánszki, Noémi
dc.contributor.author Balogh M
dc.contributor.author Vass, Noémi
dc.contributor.author Bódi P
dc.contributor.author Dezsőfi, Antal
dc.contributor.author Gárdos, László
dc.contributor.author Micskey, Éva
dc.contributor.author Papp, Mária
dc.contributor.author Cseh, Áron
dc.contributor.author Szabó, Dolóresz
dc.contributor.author Vörös, Péter
dc.contributor.author Hungarian IBD Registry Group (HUPIR)
dc.contributor.author Veres, Gábor
dc.contributor.other Ildikó Kis
dc.contributor.other Éva Pollák
dc.contributor.other Ildikó Rosta
dc.contributor.other Károly Schultz
dc.contributor.other Ferenc Harangi
dc.contributor.other Katalin Szabados
dc.contributor.other Erzsébet Szathmári
dc.contributor.other Judit Czelecz
dc.contributor.other Katalin Szigeti
dc.contributor.other Katalin Tamás
dc.contributor.other András Tóth
dc.contributor.other Éva Vajdovich
dc.contributor.other Gabriella Tomcsa
dc.contributor.other Erika Tomsits
dc.contributor.other Kriszta Molnár
dc.contributor.other Petra A Golovics
dc.contributor.other Barbara D Lovász
dc.date.accessioned 2016-02-16T11:04:56Z
dc.date.available 2016-02-16T11:04:56Z
dc.date.issued 2013
dc.identifier 84888128443
dc.identifier.citation pagination=576-582; journalVolume=57; journalIssueNumber=5; journalTitle=JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/2486
dc.identifier.uri doi:10.1097/MPG.0b013e31829f7d8c
dc.description.abstract OBJECTIVES: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed. METHODS: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered. Twenty-seven pediatric gastroenterology centers participated in the data collection ensuring the data from the whole country. Newly diagnosed patients with IBD younger than 18 years were reported. Disease location was classified according to the Paris classification. RESULTS: A total of 420 patients were identified. The incidence rate of pediatric IBD was 7.48/10⁵ (95% confidence interval [CI] 6.34/10⁵-8.83/10⁵). The incidence for Crohn disease (CD) was 4.72/10⁵ (95% CI 3.82-5.79), for ulcerative colitis (UC) 2.32/10⁵ (95% CI 1.71-3.09), and for IBD-unclassified 0.45/10⁵ (95% CI 0.22-0.84). Most common location in CD was L3 (58.7%); typical upper gastrointestinal abnormalities (ulcer, erosion and aphthous lesion) were observed in 29.9%. Extensive colitis in patients with UC (E4, proximal to hepatic flexure) was the most common disease phenotype (57%), whereas only 5% of children had proctitis. A total of 18.6% of patients had ever severe disease (S1). Frequency of azathioprine administration at diagnosis was 29.5% in patients with CD, and this rate increased to 54.6% (130/238) at 1-year follow-up. In UC, only 3.3% received azathioprine initially, and this rate elevated to 22.5% (25/111). Use of corticosteroid decreased from 50% to 15.3% in patients with UC. Rate of bowel resection in patients with CD during the first year of follow-up was 5%. CONCLUSIONS: The incidence of pediatric IBD in Hungary was among the higher range reported. This is the first large, nationwide incident cohort analyzed according to the Paris classification, which is a useful tool to determine the characteristic pediatric CD phenotype.
dc.relation.ispartof urn:issn:0277-2116
dc.title Incidence; Paris Classification and follow-up in a nationwide; incident cohort of pediatric patients with inflammatory bowel disease
dc.type Journal Article
dc.date.updated 2015-11-20T13:58:28Z
dc.language.rfc3066 en
dc.identifier.mtmt 2325465
dc.identifier.wos 000326745900010
dc.identifier.pubmed 23820399
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/K/I. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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