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  • STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL 
    Csanády, László; Vergani Paola; Gadsby David C (2019)
    The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for salt and water transport across epithelial ...
  • Study of patterns of inheritance of premature ovarian failure syndrome carrying maternal and paternal premutations 
    Beke, A; Piko, H; Haltrich, I; Karcagi, V; Rigo, J Jr; Molnar, MJ; Fekete, G (2018)
  • Study of the Intrinsic Fluorescence of a Highly Branched Cationic Dendrimer, Poly(Ethyleneimine) (PEI) 
    Tóth, Viktória; Hermann, Péter; Végh, Dániel; Zelles, Tivadar; Géczi, Zoltán (2019)
    Poly(ethyleneimine) (PEI) is a weakly basic, synthetic, polycationic polymer, due to the presence of primary, secondary, and tertiary amino groups. The amino groups are responsible for the variety of applications of PEI ...
  • Study on medicinal chemistry of k203 in wistar rats and beagle dogs 
    Kalász Huba; Szegi Péter; Jánoki G; Balogh Lajos; Pöstényi Zita; Tekes Kornélia (2013)
    K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/ organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs ...
  • Study on Optimization of Wet Milling Process for the Development of Albendazole Containing Nanosuspension with Improved Dissolution 
    Fülöp, Viktor; Jakab, Géza; Tóth, Bence; Balogh, Emese; Antal, István (2020)
    The main objective of this work was to show the potential of the optimization of top-down wet planetary bead milling process parameters (milling speed, process time and size of the milling medium) by Design Of ...
  • Study on process parameters and optimization of microencapsulation based on phase separation 
    Lengyel Miléna; Bertalanné Balogh Emese; Szeroczei D; Dobó Nagy Csaba; Papay Z; Stommer V; Klebovich Imre; Antal István (2018)
    As surfactants are capable of influencing the droplet formation, our study primarily aims the investigation of the effect of a nonionic surfactant e.g. Polysorbate 80 on the formation of microspheres on the course of ...
  • Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation. 
    Tábi, Tamás; Szökő, Éva; Merey A,; Tóth, Veronika; Mátyus, Péter; Gyires, Klára (2013)
    SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known ...
  • Study on the antioxidant activity during the formulation of biological active ingredient 
    Pápay, Zsófia Edit; Antal, István (2014)
  • Study on the dissolution improvement of albendazole using reconstitutable dry nanosuspension formulation. 
    Fulop V; Jakab Géza; Bozó Tamás; Tóth Balázs; Endresik D; Bertalanné Balogh Emese; Kellermayer Miklós; Antal István (2018)
    The aim of the study was to improve the solubility and dissolution rate of the poorly water soluble drug albendazole via surfactant assisted media milling process. Preparation of a nanosuspension and then post-processing ...
  • Study on the hypothalamic factors mediating the inhibitory effect of PACAP38 on ovulation 
    Kántor Orsolya; Molnár Judith; Heinzlmann Andrea; Arimura A; Fürst Zsuzsanna; Köves Katalin (2001)
  • Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity 
    Pápay Zsófia Edit; Kósa Annamária; Böddi Béla; Merchant Zahra; Saleem Imran Y; Klebovich Imre; Antal István (2017)
  • Subacute cardiotoxicity caused by anthracycline therapy in children 
    Kovács, Gábor; Erlaky, Hajna; Toth K; Horvath E; Szabolcs, Judit; Csóka, Monika; Jokuti L; Erdélyi, Dániel; Müller, Judit (2007)
  • Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases? 
    Horvath, Adam; Botz, Balint; Kiss, Tamas; Cseko, Kata; Kiss, Ibolya; Felinger, Attila; Szabados, Tamara; Kenyeres, Eva; Bencsik, Peter; Mocsai, Attila; Ferdinandy, Peter; Helyes, Zsuzsanna (2019)
    Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an ...
  • Subcellular compartmentation of ascorbate and its variation in disease states. 
    Bánhegyi, Gábor; Benedetti A; Margittai, Éva; Marcolongo P; Fulceri R; Németh, Csilla Emese; Szarka, András (2014)
    Beyond its general role as antioxidant, specific functions of ascorbate are compartmentalized within the eukaryotic cell. The list of organelle-specific functions of ascorbate has been recently expanded with the epigenetic ...
  • Subclinical leaflet thrombosis is associated with impaired reverse remodelling after transcatheter aortic valve implantation 
    Szilveszter, Bálint; Oren, Daniel; Molnár, Levente Domonkos; Apor, Astrid; Nagy, Anikó Ilona; Molnár, Andrea Ágnes; Vattay, Borbála; Kolossváry, Márton József; Karády, Júlia; Bartykowszki, Andrea; Jermendy, Ádám Levente; Suhai, Ferenc Imre; Panajotu, Alexisz; Maurovich-Horvat, Pál; Merkely, Béla Péter (2020)
    Cardiac CT is increasingly applied for planning and follow-up of transcatheter aortic valve implantation (TAVI). However, there are no data available on reverse remodelling after TAVI assessed by CT. Therefore, we aimed ...
  • Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity. 
    Kutszegi, Nóra; Semsei, Ágnes F; Gézsi, András; C. Sági, Judit; Nagy V; Csordas, Katalin; Jakab, Zsuzsanna; Lautner-Csorba, Orsolya; Gabor KM; Kovács, Gábor; Erdélyi, Dániel; Szalai, Csaba (2015)
    L-asparaginase (ASP) is a key element in the treatment of paediatric acute lymphoblastic leukaemia (ALL). However, hypersensitivity reactions (HSRs) to ASP are major challenges in paediatric patients. Our aim was to ...
  • Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma 
    Zhukova N; Ramaswamy V; Remke M; Pfaff E; Shih DJ; Martin, DC; Castelo-Branco, P; Baskin, B; Ray, PN; Bouffet, E; von Bueren, AO; Jones, DT; Northcott, PA; Kool, M; Sturm, D; Pugh, TJ; Pomeroy, SL; Cho, YJ; Pietsch, T; Gessi, M; Rutkowski, S; Bognár, László; Klekner, Álmos; Cho, BK; Kim, SK; Wang, KC; Eberhart, CG; Fevre-Montange, M; Fouladi, M; French, PJ; Kros, M; Grajkowska, WA; Gupta, N; Weiss, WA; Hauser, Péter; Jabado, N; Jouvet, A; Jung, S; Kumabe, T; Lach, B; Leonard, JR; Rubin, JB; Liau, LM; Massimi, L; Pollack, IF; Shin, Ra Y; Van, Meir EG; Zitterbart, K; Schuller, U; Hill, RM; Lindsey, JC; Schwalbe, EC; Bailey, S; Ellison, DW; Hawkins, C; Malkin, D; Clifford, SC; Korshunov, A; Pfister, S; Taylor, MD; Tabori, U (2013)
    PURPOSE Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. PATIENTS AND METHODS We ...
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes 
    Northcott, PA; Shih, DJH; Peacock, J; Garzia, L; Sorana Morrissy, A; Zichner, T; Stütz, AM; Korshunov, A; Reimand, J; Schumacher, SE; Beroukhim, R; Ellison, DW; Marshall, CR; Lionel, AC; Mack, S; Dubuc, A; Yao, Y; Ramaswamy, V; Luu, B; Rolider, A; Cavalli, FMG; Wang, X; Remke, M; Wu, X; Chiu, RYB; Chu, A; Chuah, E; Corbett, RD; Hoad, GR; Jackman, SD; Li, Y; Lo, A; Mungall, KL; Ming, Nip K; Qian, JQ; Raymond, AGJ; Thiessen, N; Varhol, RJ; Birol, I; Moore, RA; Mungall, AJ; Holt, R; Kawauchi, D; Roussel, MF; Kool, M; Jones, DTW; Witt, H; Fernandez-L A; Kenney, AM; Wechsler-Reya, RJ; Dirks, P; Aviv, T; Grajkowska, WA; Perek-Polnik, M; Haberler, CC; Delattre, O; Reynaud, SS; Doz, FF; Pernet-Fattet, SS; Cho, B-K; Kim, S-K; Wang, K-C; Scheurlen, W; Eberhart, CG; Fèvre-Montange, M; Jouvet, A; Pollack, IF; Fan, X; Muraszko, KM; Yancey, Gillespie G; Di Rocco, C; Massimi, L; Michiels, EMC; Kloosterhof, NK; French, PJ; Kros, JM; Olson, JM; Ellenbogen, RG; Zitterbart, K; Kren, L; Thompson, RC; Cooper, MK; Lach, B; McLendon, RE; Bigner, DD; Fontebasso, A; Albrecht, S; Jabado, N; Lindsey, JC; Bailey, S; Gupta, N; Weiss, WA; Bognár, László; Klekner, Álmos; Van, Meter TE; Kumabe, T; Tominaga, T; Elbabaa, SK; Leonard, JR; Rubin, JB; Liau, LM; Van, Meir EG; Fouladi, M; Nakamura, H; Cinalli, G; Garami, Miklós; Hauser, Péter; Saad, AG; Iolascon, A; Jung, S; Carlotti, CG; Vibhakar, R; Shin, Ra Y; Robinson, S; Zollo, M; Faria, CC; Chan, JAD; Levy, ML; Sorensen, PHB; Meyerson, M; Pomeroy, SL; Cho, Y-J; Bader, GD; Tabori, U; Hawkins, CE; Bouffet, E; Scherer, SW; Rutka, JT; Malkin, D; Clifford, SC; Jones, SJM; Korbel, JO; Pfister, SM; Marra, MA; Taylor, MD (2012)
    Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits ...
  • Subjective health expectations of patients with age-related macular degeneration treated with antiVEGF drugs 
    Péntek, Márta; Brodszky, Valentin; Biró, Zsolt; Kolkedi Z; Dunai, Árpád; Németh, János Tibor; Baji, Petra; Rencz, Fanni; Gulácsi, László; Resch, Miklós (2017)
    BACKGROUND: Subjective expectations regarding future health may influence patients' judgement of current health and treatment effects, as well as adherence to therapies in chronic diseases. We aimed to explore subjective ...
  • Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats. 
    Serena B. Brancati; Zádori Zoltán Sándor; Németh János; Gyires Klára (2013)
    The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosal defense and to clarify the receptors and mechanisms that may be involved in it. Gastric ulceration was induced by oral ...