Interneurons operating with glycine neurotransmitter are involved in the regulation of pain transmission in the dorsal horn of the spinal cord. In addition to interneurons, glycine release also occurs from glial cells ...

Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of 'hidden cardiotoxicity' is defined as cardiotoxicity of a ...

Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuro inflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various ...

Growing data support the peripheral opioid antinociceptive effect, particularly, in inflammatory pain models. Here, we examined the antinociceptive effects of the subcutaneously (s.c.) administered, recently synthesized ...