dc.contributor.author |
Kovács, István |
|
dc.contributor.author |
Horvath M |
|
dc.contributor.author |
Lányi, Árpád |
|
dc.contributor.author |
Petheő, Gábor L. |
|
dc.contributor.author |
Geiszt, Miklós |
|
dc.date.accessioned |
2016-10-04T13:50:29Z |
|
dc.date.available |
2016-10-04T13:50:29Z |
|
dc.date.issued |
2015 |
|
dc.identifier |
84930260125 |
|
dc.identifier.citation |
pagination=1133-1137;
journalVolume=97;
journalIssueNumber=6;
journalTitle=JOURNAL OF LEUKOCYTE BIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/2667 |
|
dc.identifier.uri |
doi:10.1189/jlb.4AB1113-607RR |
|
dc.description.abstract |
Regulated production of ROS is mainly attributed to Nox family enzymes. In neutrophil granulocytes and macrophages, Nox2 has a crucial role in bacterial killing, and the absence of phagocytic ROS production leads to the development of CGD. Expression of Nox2 was also described in B lymphocytes, where the role of the enzyme is still poorly understood. Here, we show that peritoneal B cells, which were shown recently to possess phagocytic activity, have a high capacity to produce ROS in a Nox2-dependent manner. In phagocytosing B cells, intense intraphagosomal ROS production is detected. Finally, by studying 2 animal models of CGD, we demonstrate that phagocyte oxidase-deficient B cells have a reduced capacity to kill bacteria. Our observations extend the number of immune cell types that produce ROS to kill pathogens. |
|
dc.relation.ispartof |
urn:issn:0741-5400 |
|
dc.title |
Reactive oxygen species-mediated bacterial killing by B lymphocytes |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-11-24T14:48:08Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2875306 |
|
dc.identifier.wos |
000354880500014 |
|
dc.identifier.pubmed |
25821233 |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet Geiszt M
Geiszt Miklós (reaktiv oxigén származé...)
SE/AOK/I/ÉI/MTA-SE Lendület Peroxidáz Enzimek Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Petheő GL and Geiszt M contributed equally to this work. |
|