Gyógyszerek vér-agy gáton történő átjuttatásának korszerű technológiai lehetőségei

Abstract

The treatment of several central nervous system diseases is impeded due to the unique structure of the brain and the protecting function of the blood-brain barrier. On the other hand, the rapid elimination of drug particles and the consequent low therapeutic response also poses challenges for the pharmaceuticals. Nowadays, the more detailed understanding of the structure and pathophysiology of the blood-brain barrier and the development of pharmaceutical sciences enable the creation of drug delivery systems offering targeted brain delivery. The potential utilization of different types of nanoparticles for targeted delivery purposes, such as liposomes, polymeric nanoparticles and solid lipid nanocarriers have been proven by numerous research papers. Furthermore, the exploitation of physiological pathways in drug delivery, such as adsorption or cell mediated transcytosis has been gaining an increasing interest, due to their better selectivity. The aim of this paper is to provide a comprehensive review on the modern approaches for targeted brain drug delivery.