dc.contributor.author |
Bubenyák, Máté Dániel |
|
dc.contributor.author |
Palfi M, |
|
dc.contributor.author |
Takacs M, |
|
dc.contributor.author |
Béni, Szabolcs |
|
dc.contributor.author |
Szökő, Éva |
|
dc.contributor.author |
Noszál, Béla |
|
dc.contributor.author |
Kökösi, József |
|
dc.date.accessioned |
2016-02-18T11:12:54Z |
|
dc.date.available |
2016-02-18T11:12:54Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
46049110084 |
|
dc.identifier.citation |
pagination=4937-4940;
journalVolume=49;
journalIssueNumber=33;
journalTitle=TETRAHEDRON LETTERS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3094 |
|
dc.identifier.uri |
doi:10.1016/j.tetlet.2008.05.141 |
|
dc.description.abstract |
The synthesis of 7,12-dihydroindolo[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one, a hybrid compound containing common structural features of the natural alkaloids rutaecarpine (Evodia rutaecarpa) and luotonin A (Peganum nigellastrum), was performed by active methylene group transformations of deoxyvasicinone. The synthesis of 7-hydroxy-8-norrutaecarpine was accomplished via the first total synthesis of bouchardatine (Bouchardatia neurococca) and its acid-catalyzed ring closure. The synthesized alkaloid analogues are the first representatives of a new heterocyclic ring system. Preliminary testing of the synthesized compounds showed cytotoxic activities against HeLa cells and apoptosis inducing effects at a concentration comparable to that of the control drug, etoposide. (C) 2008 Elsevier Ltd. All rights reserved. |
|
dc.relation.ispartof |
urn:issn:0040-4039 |
|
dc.title |
Synthesis of hybrids between the alkaloids rutaecarpine and luotonins A, B |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-02-15T10:14:57Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1303077 |
|
dc.identifier.wos |
000258274200034 |
|
dc.contributor.department |
SE/GYTK/Gyógyszerészi Kémiai Intézet |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|