dc.contributor.author |
Törzsök, Péter |
|
dc.contributor.author |
Riesz, Péter |
|
dc.contributor.author |
Kenessey, István |
|
dc.contributor.author |
Székely, Eszter |
|
dc.contributor.author |
Somorácz, Áron |
|
dc.contributor.author |
Nyirády, Péter |
|
dc.contributor.author |
Romics, Imre |
|
dc.contributor.author |
Schaff, Zsuzsa |
|
dc.contributor.author |
Lotz, Gábor |
|
dc.contributor.author |
Kiss, András |
|
dc.date.accessioned |
2017-01-05T15:35:41Z |
|
dc.date.available |
2017-01-05T15:35:41Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
84555191362 |
|
dc.identifier.citation |
pagination=1022-1030;
journalVolume=59;
journalIssueNumber=11;
journalTitle=JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3440 |
|
dc.identifier.uri |
doi:10.1369/0022155411424606 |
|
dc.description.abstract |
Updated classification of urothelial cell cancer differentiates
low-grade and high-grade cancers, which determines potential
clinical outcome. Substantial interobserver variability
necessitates new biomarkers to ensure classification. Claudins'
specific expression pattern characterizes normal tissues,
different tumor types, and defined grades of tumor
differentiation. The aim of this study was to examine the
expression pattern of claudins and proliferation marker Ki-67
in low-grade and high-grade urothelial cell cancers compared
with independent control samples of non-tumorous urothelium, as
well as to reveal the predictive usefulness of claudins. The
expression of claudins-1, -2, -3, -4, -5, -7, and -10 and Ki-67
was studied with quantitative immunohistochemistry and real-time
RT-PCR with relative quantification in 103 samples: 86
urothelial cell cancers (27 low grade, 59 high grade) and 17
non-tumorous urothelia. Results were analyzed regarding overall
survival and recurrence-free period as well. High-grade tumors
overall showed significantly higher claudin-4 and Ki-67 and
significantly lower claudin-7 expression when compared with low-
grade ones. High-grade tumors revealed significantly shorter
overall survival in Kaplan-Meier analysis. Claudin-4, claudin-7,
and Ki-67 might be used as potential markers to differentiate
low-grade and high-grade urothelial cell cancers, thereby
possibly enhancing accuracy of pathological diagnosis and
adding further information to clinical outcome. |
|
dc.relation.ispartof |
urn:issn:0022-1554 |
|
dc.title |
Claudins and ki-67: potential markers to differentiate low- and high-grade transitional cell carcinomas of the urinary bladder |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-06-08T12:13:40Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1752225 |
|
dc.identifier.wos |
000296361100006 |
|
dc.identifier.pubmed |
22043024 |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.department |
SE/AOK/K/Urológiai Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Péter Törzsök and Péter Riesz contributed equally to this work
Gábor Lotz and András Kiss contributed equally to this work |
|