dc.contributor.author |
Dezső, Katalin |
|
dc.contributor.author |
Halász, Judit |
|
dc.contributor.author |
Bisgaard HC, |
|
dc.contributor.author |
Paku, Sándor |
|
dc.contributor.author |
Turányi, Eszter |
|
dc.contributor.author |
Schaff, Zsuzsa |
|
dc.contributor.author |
Nagy, Péter |
|
dc.date.accessioned |
2017-01-25T14:48:47Z |
|
dc.date.available |
2017-01-25T14:48:47Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
41049114702 |
|
dc.identifier.citation |
pagination=443-448;
journalVolume=452;
journalIssueNumber=4;
journalTitle=VIRCHOWS ARCHIV; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3494 |
|
dc.identifier.uri |
doi:10.1007/s00428-007-0571-8 |
|
dc.description.abstract |
Delta-like protein (DLK) is a membrane protein with mostly
unknown function. It is expressed by several embryonic tissues
among others by the hepatoblasts of rodent and human fetal
livers. We have investigated in the present study if this
protein is expressed in human hepatoblastomas. The presence of
DLK has been studied by standard immunohistochemistry in 31
hepatoblastomas and in several differential diagnostically
related tumours: hepatocellular carcinomas and in
undifferentiated childhood neoplasms. All the hepatoblastomas
were positive for DLK; the surrounding liver tissue remained
negative. The reaction was present in the epithelial component
of the tumours. The staining pattern was mostly membranous,
occasionally cytoplasmic. The other studied tumours were
negative for DLK, except one hepatocellular carcinoma and the
differentiating cells of two ganglioneuroblastomas. Therefore,
DLK seems to be a highly sensitive and specific marker for
hepatoblastomas. |
|
dc.relation.ispartof |
urn:issn:0945-6317 |
|
dc.title |
Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas |
|
dc.type |
Journal Article |
|
dc.date.updated |
2016-06-09T10:19:13Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1127205 |
|
dc.identifier.wos |
000254207900012 |
|
dc.identifier.pubmed |
18236070 |
|
dc.contributor.department |
SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Dezső K and Halász J contributed equally to this work. |
|