dc.contributor.author |
Jakab, Csaba |
|
dc.contributor.author |
Rusvai, Miklós |
|
dc.contributor.author |
Gálfi, Péter |
|
dc.contributor.author |
Szabó Z |
|
dc.contributor.author |
Szabára, Ágnes |
|
dc.contributor.author |
Kulka, Janina |
|
dc.date.accessioned |
2016-12-15T12:31:36Z |
|
dc.date.available |
2016-12-15T12:31:36Z |
|
dc.date.issued |
2010 |
|
dc.identifier.citation |
pagination=55-62;journalVolume=25;journalTitle=HISTOLOGY AND HISTOPATHOLOGY; |
hu |
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/3526 |
|
dc.description.abstract |
The aim of the present study was to characterise the expression pattern of claudin-1, -3, -4, -5 and -7 tight junction proteins in canine normal colorectum and in the low-grade, tubulopapillary colorectal carcinoma in canines. Methods and results: The biopsy samples included 10 canine normal colorectal tissues and 20 canine low grade colorectal carcinomas (CLGCCs). The canine normal colorectal mucosa was negative for claudin-1. Claudin-1 was detected as a non-diffuse intense membrane labelling of neoplastic epithelial cells in low grade colorectal cancer in canines. Fifty five per cent of all tumours showed a weak cytoplasmic pattern of staining for claudin-1 protein. The normal colorectal mucosa showed diffuse punctate positivity for claudin-3. Claudin-3 was detected as an intense lateral membrane labelling of tumour cells in CLGCCs. Claudin-4 expression in surface and crypt epithelial cells of the intact colorectal mucosa in canines was punctate. Claudin-4 molecule was detected as a lateral membrane labelling of neoplastic cells in CLGCCs. The epithelium of the CLGCCs and the low grade colorectal carcinoma were negative for claudin-5. The surface and crypt epithlial cells of the canine normal colorectal mucosa showed a diffuse lateral membranous pattern of staining for claudin-7. Claudin-7 molecule was detected as an intense membrane labelling of neoplastic cells in CLGCCs. Seventy per cent of all tumours showed weak cytoplasmic positivity for claudin-7. Conclusion: Consequently, we hypothesize that claudin-1 plays a role in the progression of CLGCCs. Further functional studies are needed to clarify the biological role of the mislocalization of the claudin-1 molecule from cell membrane to the cytoplasm in CLGCCs. Lower claudin-4 expression suggests that reduced expression of claudin-4 molecule may lead to cellular disorientation, detachment and invasion of CLGCCs. Further functional studies are needed to clarify the biological role of overexpression and mislocalisation of claudin-7 in CLGCCs. |
hu |
dc.relation.ispartof |
urn:issn:0213-3911 |
|
dc.title |
Expression of claudin-1, -3, -4, -5 and -7 proteins in low grade colorectal carcinoma of canines |
hu |
dc.type |
Journal Article |
hu |
dc.date.updated |
2016-06-09T13:07:06Z |
|
dc.language.rfc3066 |
en |
hu |
dc.identifier.mtmt |
1435677 |
|
dc.identifier.wos |
000272012600006 |
|
dc.identifier.pubmed |
19924641 |
|
dc.contributor.department |
Semmelweis Egyetem |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.department |
SZIE/Állatorvostudományi Kar |
|
dc.contributor.department |
SZIE/ÁOTK/Állat-egészségügyi igazgatástani és agrárgazdaságtani tanszék |
|
dc.contributor.department |
SZIE/ÁOTK/Patológiai Tanszék |
|
dc.contributor.department |
SZIE/ÁOTK/Gyógyszertani és méregtani tanszék |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.contributor.institution |
Szent István Egyetem |
|