Show simple item record Schaefer B Bartosova M MacHer-Goeppinger S Ujszászi, Ákos Wallwiener M Nyarangi-Dix J Sallay, Péter Burkhardt D Querfeld U Pfeifle V Lahrmann B Schwenger V Wühl E Holland-Cunz S Schaefer F Schmitt CP 2016-06-17T07:03:46Z 2016-06-17T07:03:46Z 2016
dc.identifier 84959017803
dc.identifier.citation pagination=21344-; journalVolume=6; journalTitle=SCIENTIFIC REPORTS;
dc.identifier.uri doi:10.1038/srep21344
dc.description.abstract The peritoneum plays an essential role in preventing abdominal frictions and adhesions and can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal and 69 omental specimens were obtained from 107 patients (0.1-60 years) undergoing surgery for disease not affecting the peritoneum for automated quantitative histomorphometry and immunohistochemistry. The mesothelial cell layer morphology and protein expression pattern is similar across all age groups. Infants below one year have a thinner submesothelium; inflammation, profibrotic activity and mesothelial cell translocation is largely absent in all age groups. Peritoneal blood capillaries, lymphatics and nerve fibers locate in three distinct submesothelial layers. Blood vessel density and endothelial surface area follow a U-shaped curve with highest values in infants below one year and lowest values in children aged 7-12 years. Lymphatic vessel density is much lower, and again highest in infants. Omental blood capillary density correlates with parietal peritoneal findings, whereas only few lymphatic vessels are present. The healthy peritoneum exhibits major thus far unknown particularities, pertaining to functionally relevant structures, and subject to substantial changes with age. The reference ranges established here provide a framework for future histomorphometric analyses and peritoneal transport modeling approaches. © 2016, EDP Science. All rights reserved.
dc.relation.ispartof urn:issn:2045-2322
dc.title Quantitative Histomorphometry of the Healthy Peritoneum
dc.type Journal Article 2016-06-14T09:32:33Z
dc.language.rfc3066 en
dc.identifier.mtmt 3067589
dc.identifier.pubmed 26905058
dc.contributor.department SE/AOK/I/Kórélettani Intézet
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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