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dc.contributor.author Németh, Tamás
dc.contributor.author Mócsai, Attila
dc.date.accessioned 2016-08-23T06:23:43Z
dc.date.available 2016-08-23T06:23:43Z
dc.date.issued 2016
dc.identifier.citation pagination=412-424; journalVolume=37; journalIssueNumber=6; journalTitle=TRENDS IN IMMUNOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/3637
dc.identifier.uri doi:10.1016/j.it.2016.04.002
dc.description.abstract As the first line of innate immune defense, neutrophils need to mount a rapid and robust antimicrobial response. Recent studies implicate various positive feedback amplification processes in achieving that goal. Feedback amplification ensures effective migration of neutrophils in shallow chemotactic gradients, multiple waves of neutrophil recruitment to the site of inflammation, and the augmentation of various effector functions of the cells. We review here such positive feedback loops including intracellular and autocrine processes, paracrine effects mediated by lipid (LTB4), chemokine, and cytokine mediators, and bidirectional interactions with the complement system and with other immune and non-immune cells. These amplification mechanisms are not only involved in antimicrobial immunity but also contribute to neutrophil-mediated tissue damage under pathological conditions. © 2016 Elsevier Ltd.
dc.relation.ispartof urn:issn:1471-4906
dc.title Feedback Amplification of Neutrophil Function
dc.type Journal Article
dc.date.updated 2016-08-18T09:48:00Z
dc.language.rfc3066 en
dc.identifier.mtmt 3085709
dc.identifier.wos 000377315600009
dc.identifier.scopus 84976385732
dc.identifier.pubmed 27157638
dc.contributor.department SE/AOK/I/Élettani Intézet
dc.contributor.department SE/AOK/I/ÉI/MTA-SE Lendület Gyulladásélettani Kutatócsoport
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote FELTÖLTŐ: Sonnevend Kinga - sonnevend.kinga@med.semmelweis-univ.hu N1 Funding Details: LP2013-66, MTA, Hungarian Academy of Sciences


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