Lymphocyte calcium influx kinetics in multiple sclerosis treated without or with interferon beta

dc.contributor.author	Toldi, Gergely
dc.contributor.author	Folyovich, András
dc.contributor.author	Simon, Zsuzsa
dc.contributor.author	Zsiga, Katalin
dc.contributor.author	Kaposi, Ambrus
dc.contributor.author	Mészáros, Gergő
dc.contributor.author	Tulassay, Tivadar
dc.contributor.author	Vásárhelyi, Barna
dc.date.accessioned	2016-08-22T07:25:21Z
dc.date.available	2016-08-22T07:25:21Z
dc.date.issued	2011
dc.identifier	80051475537
dc.identifier.citation	pagination=80-86; journalVolume=237; journalIssueNumber=1-2; journalTitle=JOURNAL OF NEUROIMMUNOLOGY;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/3642
dc.identifier.uri	doi:10.1016/j.jneuroim.2011.06.008
dc.description.abstract	Kv1.3 and IKCa1 potassium channels play an important role in the maintenance of calcium-influx during lymphocyte activation and present a possible target for selective immunomodulation. We investigated the calcium-influx characteristics of Th1, Th2, CD4, CD8 T-lymphocytes isolated from multiple sclerosis patients without or with interferon-beta therapy, and its modulation by Kv1.3 and IKCa1 channel inhibitors using flow cytometry. Specific immunomodulation of the CD8 subset can be reached through inhibition of Kv1.3 channels in multiple sclerosis patients without interferon-beta. However, this effect is not specific enough concerning all lymphocyte subsets influencing the autoimmune response, since it also affects anti-inflammatory Th2 cells.
dc.relation.ispartof	urn:issn:0165-5728
dc.title	Lymphocyte calcium influx kinetics in multiple sclerosis treated without or with interferon beta
dc.type	Journal Article
dc.date.updated	2016-08-19T09:03:15Z
dc.language.rfc3066	en
dc.identifier.mtmt	1780036
dc.identifier.wos	000294933800011
dc.identifier.pubmed	21764463
dc.contributor.department	SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department	SE/AOK/I/Laboratóriumi Medicina Intézet
dc.contributor.institution	Semmelweis Egyetem